LTIP187A - 4,13-dioxabicyclo[8,2,1]tridecenon derivatives,process and intermediates for their preparation and pharmaceutical compositions containing them - Google Patents
4,13-dioxabicyclo[8,2,1]tridecenon derivatives,process and intermediates for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- LTIP187A LTIP187A LTIP187A LTIP187A LTIP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A
- Authority
- LT
- Lithuania
- Prior art keywords
- derivatives
- dioxabicyclo
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- GRCGQCCTSGTTKZ-UHFFFAOYSA-N 7,13-dioxabicyclo[8.2.1]tridec-10-en-9-one Chemical class O=C1COCCCCCC2CC=C1O2 GRCGQCCTSGTTKZ-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- -1 -isopropyl erythromycin derivatives Chemical class 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- CYIFVRUOHKNECG-UHFFFAOYSA-N tridecan-2-one Chemical class CCCCCCCCCCCC(C)=O CYIFVRUOHKNECG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
4.13-Dioksabiciklo[8.2.1]tridekanono dariniai jų gavimo būdas, tarpiniai produktai jiems gauti ir juos turinčios farmacinės kompozicijos.@Aprašyti ciklu susiaurinti N-demetil-N-izopropil-eritromicinoA dariniai, pasižymintys virškinimo traktui efektyviomis motilin-agonistinėmis savybėmis, ir jų gavimas.4.13-Dioxabicyclo [8.2.1] tridecanone derivatives, process for their preparation, intermediate products containing them and pharmaceutical compositions containing them. @ Described cyclic N-demethyl-N-isopropyl erythromycin derivatives having gastrointestinal efficacy of motilin-agonist properties, and reception.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4200145A DE4200145A1 (en) | 1992-01-07 | 1992-01-07 | 7,10-EPOXY-OXACYCLODODANE DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP187A true LTIP187A (en) | 1994-03-25 |
| LT3015B LT3015B (en) | 1994-08-25 |
Family
ID=6449136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP187A LT3015B (en) | 1992-01-07 | 1992-12-22 | 4,13-DIOKSABICIKL £ 8.2.1 | TRIDECANON DENTAL, RECYCLING, INTERMEDIATE PRODUCTS FOR YOUR CONTENT AND CONTENT PHARMACEUTICAL COMPOSITIONS |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5418224A (en) |
| EP (1) | EP0550895B1 (en) |
| JP (1) | JP3300084B2 (en) |
| KR (1) | KR100273937B1 (en) |
| CN (1) | CN1033646C (en) |
| AT (1) | ATE155478T1 (en) |
| AU (1) | AU667699B2 (en) |
| CA (1) | CA2086811C (en) |
| CZ (1) | CZ281773B6 (en) |
| DE (2) | DE4200145A1 (en) |
| DK (1) | DK0550895T3 (en) |
| DZ (1) | DZ1652A1 (en) |
| ES (1) | ES2104808T3 (en) |
| FI (1) | FI106862B (en) |
| GR (1) | GR3024859T3 (en) |
| HU (2) | HU212272B (en) |
| IL (1) | IL104158A (en) |
| LT (1) | LT3015B (en) |
| LV (1) | LV10458B (en) |
| MX (1) | MX9300045A (en) |
| NO (1) | NO179586C (en) |
| PH (1) | PH30098A (en) |
| RU (1) | RU2107070C1 (en) |
| SK (1) | SK279251B6 (en) |
| TW (1) | TW238308B (en) |
| UA (1) | UA29393C2 (en) |
| ZA (1) | ZA9339B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9802433A3 (en) * | 1995-10-13 | 2000-03-28 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
| CA2247929A1 (en) * | 1996-03-01 | 1997-09-04 | Miichiro Arita | Processes for the preparation of erythromycin derivatives |
| US6077943A (en) * | 1996-03-01 | 2000-06-20 | Takeda Chemical Industries, Ltd. | Method of producing erythromycin derivative |
| DE19644195A1 (en) * | 1996-10-24 | 1998-04-30 | Solvay Pharm Gmbh | 10,13,15-Trioxatricyclo [9.2.1.1. · 9 ·. · 6 ·] -pentadecanone derivatives, processes for their preparation and pharmaceuticals containing these compounds |
| DE19805822B4 (en) * | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo [8.2.1] tridecenone derivatives, process for their preparation and medicaments containing these compounds |
| US6165985A (en) * | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| HRP980496B1 (en) * | 1998-09-10 | 2007-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | New thilozine hydroxy derivatives and a process for the preparation thereof |
| WO2002014338A1 (en) * | 2000-08-17 | 2002-02-21 | The Kitasato Institute | Novel pseudoerythromycin derivatives |
| KR100554562B1 (en) * | 2000-09-01 | 2006-03-03 | 쥬가이 세이야쿠 가부시키가이샤 | Process for preparing erythromycin derivative |
| JP2004529184A (en) * | 2001-05-10 | 2004-09-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Novel 1-amidomethylcarbonyl-piperidine derivatives, methods and intermediates for producing the derivatives, and medicaments containing these compounds |
| US20040067896A1 (en) * | 2002-07-25 | 2004-04-08 | The Kitasato Institute | Novel pseudoerythromycin derivatives |
| DE602004025569D1 (en) | 2003-06-18 | 2010-04-01 | Tranzyme Pharma Inc | MACROCYCLIC MOTILIN RECEPTOR ANTAGONISTS |
| US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| BRPI0619556A2 (en) * | 2005-12-08 | 2011-10-04 | Pfizer | process for 3'-dimethyl amino group demethylation of erythromycin compounds |
| JP5684474B2 (en) | 2006-09-11 | 2015-03-11 | オセラ セラピューティクス， インコーポレイテッド | Macrocyclic antagonist of motilin receptor for the treatment of gastrointestinal dysmotility disease |
| MX2009005977A (en) * | 2006-12-05 | 2009-06-17 | Pfizer | Motilde polymorphs. |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| WO2014156339A1 (en) * | 2013-03-25 | 2014-10-02 | ゼリア新薬工業株式会社 | Postprandial gastrokinetic agent |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725385A (en) * | 1970-11-02 | 1973-04-03 | Abbott Lab | Process for the demethylation of 3-amino macrolides |
| US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
| CA1321581C (en) * | 1987-05-26 | 1993-08-24 | Herbert A. Kirst | Ring-contracted macrolides |
| US4920102A (en) | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
-
1992
- 1992-01-07 DE DE4200145A patent/DE4200145A1/en not_active Withdrawn
- 1992-11-18 CZ CS923414A patent/CZ281773B6/en not_active IP Right Cessation
- 1992-11-18 SK SK3414-92A patent/SK279251B6/en unknown
- 1992-12-13 DZ DZ920162A patent/DZ1652A1/en active
- 1992-12-18 PH PH45475A patent/PH30098A/en unknown
- 1992-12-18 IL IL104158A patent/IL104158A/en not_active IP Right Cessation
- 1992-12-21 HU HU9204076A patent/HU212272B/en not_active IP Right Cessation
- 1992-12-22 LT LTIP187A patent/LT3015B/en not_active IP Right Cessation
- 1992-12-23 US US07/996,083 patent/US5418224A/en not_active Expired - Lifetime
- 1992-12-24 DK DK92122011.7T patent/DK0550895T3/en active
- 1992-12-24 AT AT92122011T patent/ATE155478T1/en not_active IP Right Cessation
- 1992-12-24 DE DE59208710T patent/DE59208710D1/en not_active Expired - Fee Related
- 1992-12-24 ES ES92122011T patent/ES2104808T3/en not_active Expired - Lifetime
- 1992-12-24 EP EP92122011A patent/EP0550895B1/en not_active Expired - Lifetime
- 1992-12-28 KR KR1019920026335A patent/KR100273937B1/en not_active Expired - Fee Related
- 1992-12-30 RU RU92016224A patent/RU2107070C1/en not_active IP Right Cessation
-
1993
- 1993-01-05 ZA ZA9339A patent/ZA9339B/en unknown
- 1993-01-06 JP JP00055793A patent/JP3300084B2/en not_active Expired - Fee Related
- 1993-01-06 LV LVP-93-01A patent/LV10458B/en unknown
- 1993-01-06 CA CA002086811A patent/CA2086811C/en not_active Expired - Fee Related
- 1993-01-06 AU AU31036/93A patent/AU667699B2/en not_active Ceased
- 1993-01-06 NO NO930029A patent/NO179586C/en unknown
- 1993-01-06 CN CN93100166A patent/CN1033646C/en not_active Expired - Fee Related
- 1993-01-07 MX MX9300045A patent/MX9300045A/en not_active IP Right Cessation
- 1993-01-07 FI FI930051A patent/FI106862B/en active
- 1993-03-25 TW TW082102267A patent/TW238308B/zh active
- 1993-04-22 UA UA93002699A patent/UA29393C2/en unknown
-
1994
- 1994-09-30 HU HU94P/P00031P patent/HU210216A9/en unknown
-
1997
- 1997-09-24 GR GR970402503T patent/GR3024859T3/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD9A | Change of patent owner |
Free format text: SOLVAY PHARMACEUTICALS GMBH,HANS-BOECKLER-ALLEE 20, D-30173 HANNOVER,DE,19970725 |
|
| MM9A | Lapsed patents |
Effective date: 20081222 |