LT4514B - Antiseptical curative oinment - Google Patents

Abstract

This invention is related to antiseptic curative ointments used in the veterinary industry for prophylaxis and treatment of bacteria, viruses and fungi generated skin diseases, i.e. for skin protection against fragmentation, dryness, for prophylaxis of mastitis, and for wound, wart and inflammation treatment. This ointment consists of (in mass percentage): fir tree resin (10.5-15.0), bee wax (3.0-4.0), salicylic acid (4.9-5.1), ethyl alcohol (2.0-3.0), medical Vaseline (6.0-7.5) and melted nutrient animal fat (up to 100). The need is 5-10 g twice a day using it as prevention, for wound and wart treatment and for udder swelling treatment 30-50 g after each milking session.

Description

The invention relates to antiseptic therapeutic ointments for use in veterinary medicine for the prophylaxis and treatment of skin diseases caused by bacteria, viruses and fungi, e.g. skin protection against breakage, dryness, prophylaxis of mastitis, as well as wounds, warts, inflammation, dermatitis and the like.

The said skin diseases may be treated with inhibitors, i.e., antibiotics, sulfanylamides, disinfectants. However, when used in the treatment of udder diseases, these substances enter the milk and render it unusable (Healthy udder - the basis for good quality milk production, PHARE Journal, published by the Lithuanian Agricultural Advisory Service, Vilnius, 1997, pp. 24-25).

Jodosol is a well-known veterinary medicinal product manufactured in aerosol form by GALENA OPAVA, Czech Republic (instructions for use), for external use in the treatment of warts and chicken pox.

The disadvantage of this preparation is the low effectiveness of the treatment and the consistency of the preparation is temperature dependent.

The closest to the patented is the EVIJA ointment for the treatment of burns and wounds. WITH AUTHORIZATION NO. 10770874 A61K 9/06, 22.06.1981), consisting of an activating agent - spruce gum and a filler consisting of beeswax, butter and lard.

The lack of EVIJA ointment is the lack of efficacy of the treatment.

SUMMARY OF THE INVENTION The object of the present invention is to increase the efficiency of the oil treatment while maintaining the consistency of the oil independent of fluctuations in ambient temperature (it does not drop at plus and does not freeze at minus temperature).

This problem is solved by the patented ointment in its composition by addition of ethyl alcohol and salicylic acid to the EVIJA ointment and replacing the butter with medicinal petroleum jelly at the following relative weight percent of the components:

fir resin 10.5-15.0 beeswax 3.0-4.0 salicylic acid 4.9-5.1 ethyl alcohol 2.0-3.0 (TS 10-0334797-10-91) medicinal petroleum jelly 6, 0-7,5 rendered edible animal fats up to 100.

The advantage of the patented ointment is that the addition of ethyl alcohol, salicylic acid to the known ointment and the replacement of the butter with medicinal petroleum jelly in the amounts specified in the definition results in a high treatment efficiency.

The method of producing the ointment consists of the following operations: adding 4.0% by weight of beeswax to a stainless steel or aluminum vessel and 6.0% by weight of medicinal petroleum jelly, 10% by weight of spruce resin and rendered edible animal fat eg pigs. fat, 73.0% by weight (up to a missing 100% by weight). o

Heat both dishes at 110 ° C for 1 hour. The contents of the container with spruce gum and lard are then fi lled, and then the contents of the container are filled. The mixture is heated at 125 ° C for 1 h, then filtered and cooled to 50 ° C. 5% salicylic acid powder 5.0% w / w and 2% ethyl alcohol 2.0% w / w in an enameled vessel. Mix the ingredients well to obtain a creamy mass of the sour cream, then add it to the pre-prepared and cooled mixture of fir resin, beeswax, medicinal petroleum jelly and lard oil. Mix thoroughly for 5 minutes, then wrap in clean dark glass jars. Examples of specific fulfillment are shown in Table 1. A yellowish, dense consistency with a pleasant smell of fir resin is obtained. At body temperature the ointment dissolves and penetrates easily into the subcutaneous layers. The ointment is an active antiseptic and accelerates the healing of open wounds.Initially acts as antibacterial, anti-inflammatory and dehydrating. In the second stage, it stimulates the regeneration process, helps wound closure, prevents the bandage from sticking to the wound or burn site.

Microorganisms such as streptococci, staphylococci, escherichiae and abscess bacteria are the major causes of mastitis. Mastitis is an inflammation of the mammary gland. (Healthy udder-g'er quality milk production basis, PHARE publication, courtesy of Lithuanian Agricultural Advisory Service, Vilnius, 1997, psi.17). Therefore, the use of a patented ointment for prophylaxis of mastitis is very important.

EXPERIMENTAL DATA

In order to determine the stability of the characteristics of the patented ointment prepared according to the composition of Table 1,2,3 in Table 1, it was stored in 50g vials for 12 months at 8-15 ° C. During this time, neither the consistency nor the smell of the ointment changed, and the total and salicylic acid levels varied within the limits set out in the Provisional Pharmacopoeia in its article LFSvet 3-193191-2.

The shelf life of the lubricant is one year from the date of manufacture. Remained stable under the influence of ultraviolet rays.

No adverse effects on animals. No adverse effects were found on the skin of the hands of the milkers.

The antimicrobial activity of the patented ointment was investigated by diffusion agar method. Meat peptone medium containing 3% agar and Müller-Hinton agar was used for this purpose. Ant. The performance of the imi-cot grease was studied using Sabur agar.

The results of the antimicrobial and antimycotic activity of the lubricants under laboratory conditions are shown in Table 2. It shows that the patented ointment had a better micro and fungal performance under laboratory conditions than EVIJA ointment. The patented ointment performed best on streptococci and fungi (sensitivity zones 1.22 and 1.4 mm, respectively). The ointment EVUA fungus Candida albicans did not work. The patented lubricant has a statistical reliability coefficient of P for fungi (0.000000018) and worst for perches (0.02550387), with an upper limit of 0.05 in the statistical analysis textbooks.

The efficacy of the treatment was determined in 120 cows, which were divided into groups by analogues. These cows were diagnosed with udder skin disease in clinical trials. The treated udder surface of the cows in the experimental group was treated with a patent ointment of 5-10 g at udder swellings of 30-50 g after each milking, the kc1 animal recovered. For comparison, analogous disorders were treated with EVUA ointment and control A and B ointments, as shown in Table 1. The results of the experiment are shown in Table 3. The duration of treatment with the patented ointment was found to be shorter from 1 to 18 days compared to the duration of treatment with EVUA ·. Wart removal time was particularly shortened (1.5-1.7 times). It can be seen from Table 3 that the use of control A and B ointments resulted in a lower treatment efficiency compared to the p a t e n t u r e.

Claims (5)

DEFINITION OF INVENTION 1.Antiseptic therapeutic ointment consisting of spruce gum, beeswax and rendered animal fat, characterized by the addition of ethyl alcohol, salicylic acid and medicinal petroleum jelly in a proportion by weight in the following proportions: fir resin 10.0 - 15.0 beeswax 3.0-4.0 Salicylic acid 4.9-5.1 ethyl alcohol 2.0-3.0 medicinal petroleum jelly 6.0 - 7.5 rendered foods animal fat- up to 100. 2. A process for the manufacture of an ointment according to claim 1, wherein the beeswax is mixed with medicinal vaseline and the fir resin is melted with edible animal fats, the two mixtures being separately heated at 110 ° C for 1 hour, then fir resin and rendered animal fat. The mixture is filtered, then added to a mixture of beeswax and medicinal petroleum jelly and heated again at 125 ° C for 1 hour, then cooled to 50 ° C and added to a well-mixed mixture of ethyl alcohol and salicylic acid, followed by vigorous stirring until grease of uniform consistency and repack. An ointment according to claim 1 for use in the treatment of udder and teat skin against fracture, for the treatment of dryness, wounds and warts, and for the prevention of mastitis at 5 to 10 g after each milking. An ointment according to claim 1 for use in the treatment of swelling of the udder, administered 30-50g after each milking. An ointment according to claim 1 for use in the treatment of abscess wounds, administered 5-10 g twice daily, after treatment of the wound with a 1: 5000 solution of potassium permanganate.