LT4200280T - Fenil-3,4-dihidroizochinolin-2(1h)-il-etan-1-ono dariniai kaip pozityvūs alosteriniai dopamino d1 receptoriaus moduliatoriai - Google Patents
Fenil-3,4-dihidroizochinolin-2(1h)-il-etan-1-ono dariniai kaip pozityvūs alosteriniai dopamino d1 receptoriaus moduliatoriaiInfo
- Publication number
- LT4200280T LT4200280T LTEPPCT/US2021/053578T LTUS2021053578T LT4200280T LT 4200280 T LT4200280 T LT 4200280T LT US2021053578 T LTUS2021053578 T LT US2021053578T LT 4200280 T LT4200280 T LT 4200280T
- Authority
- LT
- Lithuania
- Prior art keywords
- dihydroisoquinolin
- ethan
- dopamine
- phenyl
- derivatives
- Prior art date
Links
- OOGINKZYSDTICN-UHFFFAOYSA-N 1-(3,4-dihydro-1h-isoquinolin-2-yl)-2-phenylethanone Chemical class C1CC2=CC=CC=C2CN1C(=O)CC1=CC=CC=C1 OOGINKZYSDTICN-UHFFFAOYSA-N 0.000 title 1
- 102000004076 Dopamine D1 Receptors Human genes 0.000 title 1
- 108090000511 Dopamine D1 Receptors Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063088479P | 2020-10-07 | 2020-10-07 | |
| PCT/US2021/053578 WO2022076418A1 (en) | 2020-10-07 | 2021-10-05 | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1 receptor positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT4200280T true LT4200280T (lt) | 2024-04-25 |
Family
ID=78516911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2021/053578T LT4200280T (lt) | 2020-10-07 | 2021-10-05 | Fenil-3,4-dihidroizochinolin-2(1h)-il-etan-1-ono dariniai kaip pozityvūs alosteriniai dopamino d1 receptoriaus moduliatoriai |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230382869A1 (lt) |
| EP (1) | EP4200280B1 (lt) |
| JP (1) | JP2023545060A (lt) |
| CN (1) | CN116601146A (lt) |
| DK (1) | DK4200280T3 (lt) |
| ES (1) | ES2976784T3 (lt) |
| FI (1) | FI4200280T3 (lt) |
| HR (1) | HRP20240466T1 (lt) |
| HU (1) | HUE066426T2 (lt) |
| LT (1) | LT4200280T (lt) |
| MA (1) | MA60976B1 (lt) |
| MD (1) | MD4200280T2 (lt) |
| PL (1) | PL4200280T3 (lt) |
| PT (1) | PT4200280T (lt) |
| RS (1) | RS65365B1 (lt) |
| SI (1) | SI4200280T1 (lt) |
| WO (1) | WO2022076418A1 (lt) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| CN107001278B (zh) * | 2014-10-08 | 2020-11-24 | Ucb生物制药私人有限公司 | 四氢异喹啉衍生物 |
-
2021
- 2021-10-05 JP JP2023521348A patent/JP2023545060A/ja active Pending
- 2021-10-05 EP EP21802476.8A patent/EP4200280B1/en active Active
- 2021-10-05 WO PCT/US2021/053578 patent/WO2022076418A1/en active Application Filing
- 2021-10-05 RS RS20240398A patent/RS65365B1/sr unknown
- 2021-10-05 FI FIEP21802476.8T patent/FI4200280T3/fi active
- 2021-10-05 ES ES21802476T patent/ES2976784T3/es active Active
- 2021-10-05 HU HUE21802476A patent/HUE066426T2/hu unknown
- 2021-10-05 MD MDE20230653T patent/MD4200280T2/ro unknown
- 2021-10-05 SI SI202130120T patent/SI4200280T1/sl unknown
- 2021-10-05 LT LTEPPCT/US2021/053578T patent/LT4200280T/lt unknown
- 2021-10-05 PL PL21802476.8T patent/PL4200280T3/pl unknown
- 2021-10-05 MA MA60976A patent/MA60976B1/fr unknown
- 2021-10-05 US US18/030,853 patent/US20230382869A1/en active Pending
- 2021-10-05 PT PT218024768T patent/PT4200280T/pt unknown
- 2021-10-05 DK DK21802476.8T patent/DK4200280T3/da active
- 2021-10-05 CN CN202180077762.XA patent/CN116601146A/zh active Pending
- 2021-10-05 HR HRP20240466TT patent/HRP20240466T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK4200280T3 (da) | 2024-03-04 |
| US20230382869A1 (en) | 2023-11-30 |
| HUE066426T2 (hu) | 2024-08-28 |
| MA60976B1 (fr) | 2024-05-31 |
| EP4200280B1 (en) | 2024-02-21 |
| MD4200280T2 (ro) | 2024-08-31 |
| FI4200280T3 (fi) | 2024-05-03 |
| PT4200280T (pt) | 2024-03-26 |
| CN116601146A (zh) | 2023-08-15 |
| PL4200280T3 (pl) | 2024-05-20 |
| WO2022076418A1 (en) | 2022-04-14 |
| JP2023545060A (ja) | 2023-10-26 |
| HRP20240466T1 (hr) | 2024-07-05 |
| RS65365B1 (sr) | 2024-04-30 |
| EP4200280A1 (en) | 2023-06-28 |
| SI4200280T1 (sl) | 2024-04-30 |
| ES2976784T3 (es) | 2024-08-08 |
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