LT3001903T - 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof - Google Patents

1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

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Publication number
LT3001903T
LT3001903T LTEP15174246.7T LT15174246T LT3001903T LT 3001903 T LT3001903 T LT 3001903T LT 15174246 T LT15174246 T LT 15174246T LT 3001903 T LT3001903 T LT 3001903T
Authority
LT
Lithuania
Prior art keywords
pyrazolo
pyridines
therapeutic uses
therapeutic
Prior art date
Application number
LTEP15174246.7T
Other languages
Lithuanian (lt)
Inventor
John Hood
Sunil Kumar Kc
David Mark Wallace
Original Assignee
Samumed, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed, Llc filed Critical Samumed, Llc
Publication of LT3001903T publication Critical patent/LT3001903T/en

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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LTEP15174246.7T 2009-12-21 2010-12-15 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof LT3001903T (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28854409P 2009-12-21 2009-12-21

Publications (1)

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LT3001903T true LT3001903T (en) 2018-01-10

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Country Status (19)

Country Link
US (8) US8450340B2 (en)
EP (3) EP3001903B1 (en)
JP (3) JP5822844B2 (en)
CN (2) CN104546846B (en)
BR (1) BR112012018413A2 (en)
CA (2) CA2986631C (en)
CY (1) CY1119844T1 (en)
DK (1) DK3001903T3 (en)
ES (2) ES2550820T3 (en)
HK (2) HK1223247A1 (en)
HR (1) HRP20171893T1 (en)
HU (1) HUE035612T2 (en)
LT (1) LT3001903T (en)
NO (1) NO3001903T3 (en)
PL (1) PL3001903T3 (en)
PT (1) PT3001903T (en)
RS (1) RS56669B1 (en)
SI (1) SI3001903T1 (en)
WO (1) WO2011084486A1 (en)

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DK2987487T3 (en) * 2009-08-10 2020-12-07 Samumed Llc INDAZOLINE INHIBITORS OF THE WNT SIGNAL ROAD AND ITS THERAPEUTIC USES
JP2013501792A (en) * 2009-08-10 2013-01-17 サミュメッド リミテッド ライアビリティ カンパニー Indazole and its therapeutic use as WNT / B-catenin signaling pathway inhibitor
CA2986631C (en) 2009-12-21 2020-06-02 Samumed, Llc 1h-pyrazolo[3,4-.beta.]pyridines and thereapeutic uses thereof
BR112014006127A2 (en) 2011-09-14 2017-04-04 Samumed Llc indazol-3-carboxamides and their use as inhibitors of the wnt / b-catenin signaling pathway
WO2013050540A1 (en) * 2011-10-05 2013-04-11 University Of Bremen Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases
FR2984325A1 (en) * 2011-12-14 2013-06-21 Sanofi Sa PYRAZOLOPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
FR2985257B1 (en) * 2011-12-28 2014-02-14 Sanofi Sa FGFS RECEPTOR AGONISTIC DIMERS (FGFRS), PREPARATION METHOD AND THERAPEUTIC USE THEREOF
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN104271133B (en) * 2012-05-04 2017-10-13 萨穆梅德有限公司 1H pyrazolos [3,4 b] pyridine and its treatment use
MX2014015769A (en) 2012-06-29 2015-04-10 Pfizer NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS.
EP2943198B1 (en) * 2013-01-08 2019-07-17 Samumed, LLC 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
EP2981252A4 (en) * 2013-04-04 2017-02-22 Olivia Newton-John Cancer Research Institute Methods of treating diseases characterized by excessive wnt signalling
WO2014179528A2 (en) * 2013-05-01 2014-11-06 Brown Dennis M Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted naphthalimides such as amonafide for the treatment of immunological, metabolic, infectious, and benign or neoplastic hyperproliferative disease conditions
CN105683182A (en) 2013-08-30 2016-06-15 埃姆比特生物科学公司 Biaryl acetamide compounds and methods of use thereof
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