LT2513306T - C. histolyticum rekombinantinės kolagenazės ir jų gamybos būdas - Google Patents

C. histolyticum rekombinantinės kolagenazės ir jų gamybos būdas

Info

Publication number
LT2513306T
LT2513306T LTEP10818077.9T LT10818077T LT2513306T LT 2513306 T LT2513306 T LT 2513306T LT 10818077 T LT10818077 T LT 10818077T LT 2513306 T LT2513306 T LT 2513306T
Authority
LT
Lithuania
Prior art keywords
manufacture
recombinant collagenases
histolyticum recombinant
histolyticum
collagenases
Prior art date
Application number
LTEP10818077.9T
Other languages
English (en)
Inventor
Federico Bertuzzi
Angela Cuttitta
Giulio Ghersi
Salvatore Mazzola
Monica Salamone
Gregorio Seidita
Original Assignee
Abiel S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiel S.R.L. filed Critical Abiel S.R.L.
Publication of LT2513306T publication Critical patent/LT2513306T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24003—Microbial collagenase (3.4.24.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LTEP10818077.9T 2009-12-15 2010-12-15 C. histolyticum rekombinantinės kolagenazės ir jų gamybos būdas LT2513306T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2009A000661A IT1397646B1 (it) 2009-12-15 2009-12-15 Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
PCT/IB2010/055840 WO2011073925A2 (en) 2009-12-15 2010-12-15 C. histolyticum recombinant collagenases and method for the manufacture thereof

Publications (1)

Publication Number Publication Date
LT2513306T true LT2513306T (lt) 2019-06-10

Family

ID=42133732

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP10818077.9T LT2513306T (lt) 2009-12-15 2010-12-15 C. histolyticum rekombinantinės kolagenazės ir jų gamybos būdas

Country Status (7)

Country Link
US (1) US8715985B2 (lt)
EP (1) EP2513306B1 (lt)
CA (1) CA2784050C (lt)
IL (1) IL220359A (lt)
IT (1) IT1397646B1 (lt)
LT (1) LT2513306T (lt)
WO (1) WO2011073925A2 (lt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2385239B1 (es) * 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
ES2740499T3 (es) * 2012-01-12 2020-02-05 Endo Global Ventures Enzima de Clostridium histolyticum
WO2017059281A1 (en) * 2015-10-02 2017-04-06 Mcquillan Sharon Patrica Adipose-derived stem cell product
ITUB20161010A1 (it) * 2016-02-24 2017-08-24 Abiel S R L Metodo di calibrazione di collagenasi
EP3589204A1 (en) 2017-03-01 2020-01-08 Endo Ventures Limited Apparatus and method for assessing and treating cellulite
AU2018244426A1 (en) 2017-03-28 2019-10-17 Endo Ventures Limited Improved method of producing collagenase
CN108949730B (zh) * 2018-07-30 2020-05-12 杭州观苏生物技术有限公司 一种重组变构胶原酶的制备方法及其应用
WO2021076618A1 (en) 2019-10-15 2021-04-22 The Johns Hopkins University Treatment of uterine fibroids using purified collagenase
CN112941058B (zh) * 2021-04-02 2023-12-05 重庆科润生物医药研发有限公司 一种重组溶组织梭菌ii型胶原酶及其制备方法和应用
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000580A1 (en) * 1992-06-22 1994-01-06 Trigen, Inc. Molecular cloning of the genes reponsible for collagenase production from clostridium histolyticum
WO2008100833A2 (en) * 2007-02-13 2008-08-21 Auxilium International Holdings, Inc. Production of recombinant collagenases colg and colh in escherichia coli

Also Published As

Publication number Publication date
WO2011073925A2 (en) 2011-06-23
US8715985B2 (en) 2014-05-06
IT1397646B1 (it) 2013-01-18
ITRM20090661A1 (it) 2011-06-16
CA2784050A1 (en) 2011-06-23
EP2513306A2 (en) 2012-10-24
IL220359A (en) 2017-08-31
WO2011073925A9 (en) 2011-09-22
US20120252092A1 (en) 2012-10-04
WO2011073925A3 (en) 2011-08-11
CA2784050C (en) 2019-12-31
EP2513306B1 (en) 2019-03-20

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