LT2086332T - Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis - Google Patents
Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinisInfo
- Publication number
- LT2086332T LT2086332T LTEP07867349.8T LT07867349T LT2086332T LT 2086332 T LT2086332 T LT 2086332T LT 07867349 T LT07867349 T LT 07867349T LT 2086332 T LT2086332 T LT 2086332T
- Authority
- LT
- Lithuania
- Prior art keywords
- source
- stem cells
- bone marrow
- mesenchymal stem
- derived mesenchymal
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85651506P | 2006-11-03 | 2006-11-03 | |
| PCT/US2007/023184 WO2008057443A2 (en) | 2006-11-03 | 2007-11-02 | Bone marrow-derived mesenchymal stem cells as a source of neural progenitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2086332T true LT2086332T (lt) | 2018-04-25 |
Family
ID=39365076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP07867349.8T LT2086332T (lt) | 2006-11-03 | 2007-11-02 | Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US8642331B2 (lt) |
| EP (2) | EP2086332B1 (lt) |
| CA (1) | CA2668200C (lt) |
| CY (1) | CY1120115T1 (lt) |
| DK (1) | DK2086332T3 (lt) |
| ES (1) | ES2663875T3 (lt) |
| HR (1) | HRP20180533T1 (lt) |
| HU (1) | HUE036745T2 (lt) |
| LT (1) | LT2086332T (lt) |
| MX (1) | MX2009004776A (lt) |
| PL (1) | PL2086332T3 (lt) |
| PT (1) | PT2086332T (lt) |
| RS (1) | RS57083B1 (lt) |
| SI (1) | SI2086332T1 (lt) |
| WO (1) | WO2008057443A2 (lt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2086332B1 (en) | 2006-11-03 | 2018-01-10 | Multiple Sclerosis Research Center Of New York | Bone marrow-derived mesenchymal stem cells as a source of neural progenitors |
| US9301975B2 (en) | 2009-05-01 | 2016-04-05 | Biocardia, Inc. | Method of preparing autologous cells and method of use for therapy |
| US20120020931A1 (en) | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
| ES2738115T3 (es) | 2010-08-18 | 2020-01-20 | Theresa Deisher | Dexametasona para su uso en el tratamiento de osteoartritis, fallo hepático, diabetes mellitus tipo-2, ictus y enfermedad de Parkinson, en combinación con un tratamiento con células madre |
| EP3679939A1 (en) | 2010-10-08 | 2020-07-15 | Mesoblast International Sàrl | Enhanced msc preparations |
| WO2012070964A1 (ru) * | 2010-11-22 | 2012-05-31 | Farber Boris Slavinovich | Модифицированные олигопептиды с противораковыми свойствами и способ их получения |
| AU2014335680A1 (en) * | 2013-10-14 | 2016-04-07 | Hadasit Medical Research Services & Development Limited | Method of obtaining terminally differentiated neuronal lineages and uses thereof |
| WO2015143074A1 (en) * | 2014-03-20 | 2015-09-24 | University Of Southern California | Brain cancer immunotherapy |
| WO2016168993A1 (en) | 2015-04-22 | 2016-10-27 | Innolife Co., Ltd. | Methods of tissue repair and regeneration |
| EP3307072A4 (en) | 2015-06-15 | 2019-04-03 | Mayo Foundation for Medical Education and Research | USE OF AUTOLOGOUS MESENCHYMAL STEM CELLS FOR THE TREATMENT OF MULTISYSTEM ATROPHY |
| US20180369287A1 (en) | 2015-10-08 | 2018-12-27 | Neurona Therapeutics Inc. | Neural precursor cell populations and uses thereof |
| CN110709091A (zh) | 2017-05-15 | 2020-01-17 | 干细胞医药有限公司 | 使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症 |
| US11510946B2 (en) | 2017-05-15 | 2022-11-29 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
| WO2021020666A1 (en) * | 2019-07-26 | 2021-02-04 | Brexogen Inc. | Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7037719B1 (en) * | 1999-02-12 | 2006-05-02 | Stemcells California, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| US8017112B2 (en) * | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| US20040208858A1 (en) * | 2000-04-12 | 2004-10-21 | Gihan Tennekoon | Therapeutic uses for mesenchymal stromal cells |
| EP1452586B1 (en) * | 2001-10-30 | 2012-05-30 | Nc Medical Research Inc. | Method of inducing differentiation of mesodermal stem cells into nervous system cells |
| ES2524996T3 (es) * | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC |
| EP2086332B1 (en) | 2006-11-03 | 2018-01-10 | Multiple Sclerosis Research Center Of New York | Bone marrow-derived mesenchymal stem cells as a source of neural progenitors |
-
2007
- 2007-11-02 EP EP07867349.8A patent/EP2086332B1/en active Active
- 2007-11-02 CA CA2668200A patent/CA2668200C/en not_active Expired - Fee Related
- 2007-11-02 EP EP15195728.9A patent/EP3031326A3/en not_active Withdrawn
- 2007-11-02 LT LTEP07867349.8T patent/LT2086332T/lt unknown
- 2007-11-02 MX MX2009004776A patent/MX2009004776A/es active IP Right Grant
- 2007-11-02 WO PCT/US2007/023184 patent/WO2008057443A2/en active Application Filing
- 2007-11-02 US US12/377,900 patent/US8642331B2/en active Active
- 2007-11-02 RS RS20180406A patent/RS57083B1/sr unknown
- 2007-11-02 ES ES07867349.8T patent/ES2663875T3/es active Active
- 2007-11-02 HU HUE07867349A patent/HUE036745T2/hu unknown
- 2007-11-02 PT PT78673498T patent/PT2086332T/pt unknown
- 2007-11-02 PL PL07867349T patent/PL2086332T3/pl unknown
- 2007-11-02 DK DK07867349.8T patent/DK2086332T3/en active
- 2007-11-02 SI SI200732020T patent/SI2086332T1/en unknown
-
2011
- 2011-06-09 US US13/156,776 patent/US20110236357A1/en not_active Abandoned
-
2013
- 2013-12-23 US US14/139,152 patent/US9328329B2/en active Active
-
2014
- 2014-10-28 US US14/525,919 patent/US9657268B2/en active Active
- 2014-10-28 US US14/525,903 patent/US20150118198A1/en not_active Abandoned
-
2018
- 2018-03-30 HR HRP20180533TT patent/HRP20180533T1/hr unknown
- 2018-04-04 CY CY20181100378T patent/CY1120115T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150064145A1 (en) | 2015-03-05 |
| EP3031326A3 (en) | 2016-09-14 |
| US20100166712A1 (en) | 2010-07-01 |
| ES2663875T3 (es) | 2018-04-17 |
| US9328329B2 (en) | 2016-05-03 |
| EP2086332A4 (en) | 2010-08-11 |
| CA2668200A1 (en) | 2008-05-15 |
| SI2086332T1 (en) | 2018-06-29 |
| DK2086332T3 (en) | 2018-04-16 |
| PL2086332T3 (pl) | 2018-07-31 |
| US20150118198A1 (en) | 2015-04-30 |
| PT2086332T (pt) | 2018-04-04 |
| WO2008057443A9 (en) | 2008-07-17 |
| EP2086332A2 (en) | 2009-08-12 |
| CY1120115T1 (el) | 2018-12-12 |
| CA2668200C (en) | 2017-04-18 |
| US20110236357A1 (en) | 2011-09-29 |
| US9657268B2 (en) | 2017-05-23 |
| EP2086332B1 (en) | 2018-01-10 |
| US20140308745A1 (en) | 2014-10-16 |
| RS57083B1 (sr) | 2018-06-29 |
| HUE036745T2 (hu) | 2018-07-30 |
| EP3031326A2 (en) | 2016-06-15 |
| MX2009004776A (es) | 2009-07-14 |
| WO2008057443A3 (en) | 2008-11-20 |
| US8642331B2 (en) | 2014-02-04 |
| WO2008057443A2 (en) | 2008-05-15 |
| HRP20180533T1 (hr) | 2018-05-18 |
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