LT2086332T - Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis - Google Patents

Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis

Info

Publication number
LT2086332T
LT2086332T LTEP07867349.8T LT07867349T LT2086332T LT 2086332 T LT2086332 T LT 2086332T LT 07867349 T LT07867349 T LT 07867349T LT 2086332 T LT2086332 T LT 2086332T
Authority
LT
Lithuania
Prior art keywords
source
stem cells
bone marrow
mesenchymal stem
derived mesenchymal
Prior art date
Application number
LTEP07867349.8T
Other languages
English (en)
Inventor
Saud A. Sadiq
Violane K. Harris
Original Assignee
Multiple Sclerosis Research Center Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Multiple Sclerosis Research Center Of New York filed Critical Multiple Sclerosis Research Center Of New York
Publication of LT2086332T publication Critical patent/LT2086332T/lt

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
LTEP07867349.8T 2006-11-03 2007-11-02 Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis LT2086332T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85651506P 2006-11-03 2006-11-03
PCT/US2007/023184 WO2008057443A2 (en) 2006-11-03 2007-11-02 Bone marrow-derived mesenchymal stem cells as a source of neural progenitors

Publications (1)

Publication Number Publication Date
LT2086332T true LT2086332T (lt) 2018-04-25

Family

ID=39365076

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP07867349.8T LT2086332T (lt) 2006-11-03 2007-11-02 Mezenchiminės kamieninės ląstelės, gautos iš kaulų čiulpų, kaip neuroninių pradininkų šaltinis

Country Status (15)

Country Link
US (5) US8642331B2 (lt)
EP (2) EP3031326A3 (lt)
CA (1) CA2668200C (lt)
CY (1) CY1120115T1 (lt)
DK (1) DK2086332T3 (lt)
ES (1) ES2663875T3 (lt)
HR (1) HRP20180533T1 (lt)
HU (1) HUE036745T2 (lt)
LT (1) LT2086332T (lt)
MX (1) MX2009004776A (lt)
PL (1) PL2086332T3 (lt)
PT (1) PT2086332T (lt)
RS (1) RS57083B1 (lt)
SI (1) SI2086332T1 (lt)
WO (1) WO2008057443A2 (lt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009004776A (es) 2006-11-03 2009-07-14 Multiple Sclerosis Res Ct Of N Celulas madre mesenquimaticas derivadas de medula osea como una fuente de progenitores neurales.
US9301975B2 (en) 2009-05-01 2016-04-05 Biocardia, Inc. Method of preparing autologous cells and method of use for therapy
US20120020931A1 (en) 2010-06-02 2012-01-26 Rutgers, The State University Of New Jersey Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells
EP3530274A1 (en) 2010-08-18 2019-08-28 Theresa Deisher Dexamethasone to reduce stem cell accumulation in the spleen
US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
WO2012070964A1 (ru) * 2010-11-22 2012-05-31 Farber Boris Slavinovich Модифицированные олигопептиды с противораковыми свойствами и способ их получения
US10336985B2 (en) 2013-10-14 2019-07-02 Hadasit Medical Research Services & Development Limited Method of obtaining terminally differentiated neuronal lineages and uses thereof
US20170065691A1 (en) * 2014-03-20 2017-03-09 University Of Southern California Brain cancer immunotherapy
WO2016168993A1 (en) 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
WO2016205371A1 (en) * 2015-06-15 2016-12-22 Mayo Foundation For Medical Education And Research Using autologous mesenchymal stem cells to treat multiple system atrophy
WO2017062971A1 (en) 2015-10-08 2017-04-13 Neurona Therapeutics Inc. Neural precursor cell populations and uses thereof
AU2017414803A1 (en) 2017-05-15 2019-12-05 Mapi Pharma Ltd. Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells
CA3062123A1 (en) 2017-05-15 2018-11-22 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with adipose-derived stem cells
WO2021020666A1 (en) * 2019-07-26 2021-02-04 Brexogen Inc. Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037719B1 (en) * 1999-02-12 2006-05-02 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US8017112B2 (en) * 1999-05-14 2011-09-13 Henry Ford Health System Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases
US20040208858A1 (en) * 2000-04-12 2004-10-21 Gihan Tennekoon Therapeutic uses for mesenchymal stromal cells
US20040259254A1 (en) * 2001-10-30 2004-12-23 Osamu Honmou Method for inducing differentiation mesodermal stem cells, es cells or immortalized cells into nervous system cells
DK1893747T3 (en) * 2005-06-16 2014-12-01 Univ Ramot ISOLATED CELLS AND POPULATIONS INCLUDING SUCH CELLS FOR TREATING CNS DISEASES
MX2009004776A (es) 2006-11-03 2009-07-14 Multiple Sclerosis Res Ct Of N Celulas madre mesenquimaticas derivadas de medula osea como una fuente de progenitores neurales.

Also Published As

Publication number Publication date
US20150064145A1 (en) 2015-03-05
US9657268B2 (en) 2017-05-23
PT2086332T (pt) 2018-04-04
US20140308745A1 (en) 2014-10-16
PL2086332T3 (pl) 2018-07-31
WO2008057443A3 (en) 2008-11-20
EP3031326A3 (en) 2016-09-14
US8642331B2 (en) 2014-02-04
US9328329B2 (en) 2016-05-03
WO2008057443A9 (en) 2008-07-17
EP3031326A2 (en) 2016-06-15
HRP20180533T1 (hr) 2018-05-18
CA2668200A1 (en) 2008-05-15
DK2086332T3 (en) 2018-04-16
CY1120115T1 (el) 2018-12-12
HUE036745T2 (hu) 2018-07-30
US20150118198A1 (en) 2015-04-30
US20100166712A1 (en) 2010-07-01
EP2086332A4 (en) 2010-08-11
RS57083B1 (sr) 2018-06-29
CA2668200C (en) 2017-04-18
US20110236357A1 (en) 2011-09-29
MX2009004776A (es) 2009-07-14
EP2086332B1 (en) 2018-01-10
WO2008057443A2 (en) 2008-05-15
ES2663875T3 (es) 2018-04-17
EP2086332A2 (en) 2009-08-12
SI2086332T1 (en) 2018-06-29

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