LT2012035A - Process for preparing dihydroquercetin of a particularly high degree of purity - Google Patents

Process for preparing dihydroquercetin of a particularly high degree of purity

Info

Publication number
LT2012035A
LT2012035A LT2012035A LT2012035A LT2012035A LT 2012035 A LT2012035 A LT 2012035A LT 2012035 A LT2012035 A LT 2012035A LT 2012035 A LT2012035 A LT 2012035A LT 2012035 A LT2012035 A LT 2012035A
Authority
LT
Lithuania
Prior art keywords
dihydroquercetin
subjected
solution
preparing
product
Prior art date
Application number
LT2012035A
Other languages
Lithuanian (lt)
Other versions
LT6013B (en
Inventor
Natalia Kiseliova
Yury Garipov
Sergey Ponkratov
Viačeslavas MASLOVAS
Original Assignee
Uab "Rokiå Kio Pragiedruliai"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab "Rokiå Kio Pragiedruliai" filed Critical Uab "Rokiå Kio Pragiedruliai"
Priority to LT2012035A priority Critical patent/LT6013B/en
Priority to EP12806719.6A priority patent/EP2850069A1/en
Priority to PCT/LT2012/000008 priority patent/WO2013172693A1/en
Publication of LT2012035A publication Critical patent/LT2012035A/en
Publication of LT6013B publication Critical patent/LT6013B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to isolation by chromatography of (2R, 3R)-dihydroquercetin for production of biologically active supplements for medicine and pharmacy and food and cosmetics industry as well. The highly effective process for preparing (2R, 3R)-dihydroquercetin claimed enables to obtain the extremely pure product. The raw material containing dihydroquercetinis subjected to dissolution in aqueous ethanol solutionat 2-29 oC until the dihydroquercetin amount in solution of 50-250 g/l. Then the solution is subjected to chromatographic separation in a column under pressure 100-500 kg/cm2, the column being filled with reverse-phase sorbent. The sorbent is subjected to eluation with degassed modified ethyl alkohol aqueous solution. The portions of eluate are controlled by refractometry and mass spectrometry methods; then the product is subjected to crystallization, filtration and lyophylization. The product obtained contains at least 99,9 % of (2R,3R)-dihydroquercetin.
LT2012035A 2012-05-18 2012-05-18 Process for preparing dihydroquercetin of a particularly high degree of purity LT6013B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
LT2012035A LT6013B (en) 2012-05-18 2012-05-18 Process for preparing dihydroquercetin of a particularly high degree of purity
EP12806719.6A EP2850069A1 (en) 2012-05-18 2012-11-21 Process for preparing of highly pure dihydroquercetin
PCT/LT2012/000008 WO2013172693A1 (en) 2012-05-18 2012-11-21 Process for preparing of highly pure dihydroquercetin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2012035A LT6013B (en) 2012-05-18 2012-05-18 Process for preparing dihydroquercetin of a particularly high degree of purity

Publications (2)

Publication Number Publication Date
LT2012035A true LT2012035A (en) 2013-11-25
LT6013B LT6013B (en) 2014-03-25

Family

ID=47436155

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2012035A LT6013B (en) 2012-05-18 2012-05-18 Process for preparing dihydroquercetin of a particularly high degree of purity

Country Status (3)

Country Link
EP (1) EP2850069A1 (en)
LT (1) LT6013B (en)
WO (1) WO2013172693A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623548B (en) * 2018-05-02 2022-05-06 齐齐哈尔大学 Method for separating chiral eriodictyol from peanut shells and application of method
CN113214210B (en) * 2021-05-10 2022-03-04 合肥立方制药股份有限公司 Preparation method of dihydroquercetin
CN113185485B (en) 2021-05-10 2022-03-04 合肥立方制药股份有限公司 Semi-synthesis method of dihydroquercetin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2000797C1 (en) 1992-05-26 1993-10-15 Отдел химии древесины Иркутского института органической химии СО РАН Method for isolation of dihydroquercetin
RU2038094C1 (en) 1994-02-08 1995-06-27 Товарищество с ограниченной ответственностью "Инкор" Method for producing dihydroquercetin
RU2114631C1 (en) 1997-07-22 1998-07-10 Нонна Арсеньевна Тюкавкина Method of isolation of dihydroquercitin
US5912363A (en) 1997-08-29 1999-06-15 Interhealth Nutraceuticals Method for extraction of proanthocyanidins from plant material
RU2186097C1 (en) 2001-07-06 2002-07-27 Общество с ограниченной ответственностью "Сибларекс" Composition of bioflavonoid complex "sibel" for foodstuff and perfume article and method of preparing bioflavonoid complex "sibel" for foodstuff and perfume article
US7132296B2 (en) 2002-02-15 2006-11-07 Medical Products Manufacturing, Llc Method for assaying the antioxidant capacity of a sample

Also Published As

Publication number Publication date
EP2850069A1 (en) 2015-03-25
LT6013B (en) 2014-03-25
WO2013172693A1 (en) 2013-11-21

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Legal Events

Date Code Title Description
BB1A Patent application published

Effective date: 20131125

FG9A Patent granted

Effective date: 20140325

MM9A Lapsed patents

Effective date: 20170518