KR980008203A - Composition for promoting oral hygiene - Google Patents
Composition for promoting oral hygiene Download PDFInfo
- Publication number
- KR980008203A KR980008203A KR1019960027844A KR19960027844A KR980008203A KR 980008203 A KR980008203 A KR 980008203A KR 1019960027844 A KR1019960027844 A KR 1019960027844A KR 19960027844 A KR19960027844 A KR 19960027844A KR 980008203 A KR980008203 A KR 980008203A
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- acid
- oral hygiene
- promoting
- triclosan
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Abstract
The present invention relates to a composition for promoting oral hygiene which is excellent in gingival inflammation relieving effect and plaque formation inhibitory effect by containing urso dexoxycholic acid and / or chinese deoxycholic acid and triclosan.
Description
Since this is a trivial issue, I did not include the contents of the text.
Various oral diseases that appear in oral tissues are caused by plaque composed of numerous germs present in oral cavity. Clinical and pathological significance has been extensively studied, and Alexander A, G, J. Periodent, 42, 21-28, 1971), and Ash (M, M, J.Periodent, 35, 424, 1964). Acupuncture is also a unique blend of electrolytes and other constituents that play a particular role in the maintenance and digestion of oral health, and it contains a variety of enzymes. Elevated enzymatic activity of some of these saliva enzymes is found in periodontal disease. Saliva enzymes are the subject of major research. Salivary glands, serum, white blood cells, epithelial cells, and oral bacteria are involved in the production of these enzymes.
The collagenase is one of the metalloproteinases, an important substrate for degrading connective tissue. In healthy oral tissues, the protease enzyme is inactivated but active in periodontal disease patients.
Therefore, there has been a demand for development of antibacterial substances having a strong inhibitory effect on plaque formation and substances which inactivate such a protease.
As known, fel tauri (gall bladder of Bos taurus demesticus Gmelin) and gall bladder (fel ursi, Selenarctos thibetanus G, Cuiver and the like gall bladder) are herbal medicines and are used as a herbal medicine for pain relief, sedation, asthma, chronic hepatitis, The efficacy of livelihoods and inflammation has been known and widely used.
Korean Patent Laid-Open Publication Nos. 93-11992 and 93-11993 and the like disclose a method for producing a fermented soybean oil containing a combination of a humic acid salt, a glycocholic acid and a taurocholic acid, The purpose of this study was to provide the effect of removing plaque and preventive periodontal disease by applying oral hygiene product made by mixing and firing Woo - Dam (small gallbladder) juice with salt.
However, Uhuam and ugum are medicinal herbs made from animals, and they are mixed with various materials. Therefore, they are not stable when applied to products, and there is a possibility of deterioration of raw materials themselves due to storage conditions and difficulty in maintaining the uniformity of the efficacy .
In addition, in the clinical preventive dentistry (vol. 14 (16), 1992), 0.3% triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) To prevent plaque formation and to prevent periodontal disease.
However, the mouthwash and oral hygiene agents to be provided in Korean Patent Laid-Open Nos. 93-11992 and 93-11993 are somewhat inadequate in feeling and efficacy, and the tree applied for eliminating the plaque by the germicidal effect and for the periodontal disease treatment effect Croscarmellose required a high content of fungicide.
Therefore, the inventors of the present invention have conducted numerous studies and experiments in order to solve the problems of the prior art, and have shown a good effect in inactivating the collagen enzymes of Uruso deoxycinic acid and Chanode deoxycholic acid, Considering the fact that trichoric acid has excellent germicidal power against oral microorganisms and has no side effects and can be used in combination with an anion component such as fluoride toothpaste, the oral hygiene composition contains urushordes oxycholine and / or chenodesoxycholic acid and trichloroacetic acid It was found that the effect of inhibiting plaque formation and the effect of inhibiting the collagen enzyme, which is a causative substance in gingivitis, are further enhanced, and the present invention has been completed.
The present invention relates to an oral hygiene product which is excellent in the inactivation ability of a collagen enzyme which is a causative factor of periodontitis and which is a mixture of urushodesoxycinic acid and chenodesoxocholic acid which are stable to human body, And to a composition for promoting growth.
That is, the composition for promoting oral hygiene according to the present invention is excellent in the inactivation ability of the collagenase, which is a causative agent of gingivalitis, and is mixed with a certain amount of triclosan known as a bactericide, thereby increasing the suppression effect of plaque formation, Is characterized by mixing uricoside oxycholic acid and chernodesoxycolic acid, each of which is used alone or in combination of two, and trichlonic acid in a certain ratio, to prevent and treat periodontal disease and excellent caries.
In the composition for enhancing oral hygiene according to the present invention, urdosecoxycholic acid and chernosoxocholic acid are contained in an amount of 0.01 to 1.0% by weight, preferably 0.02 to 0.60% by weight, based on the total composition, By weight to 1.0% by weight.
In the present invention, when urosodexoxycholic acid and chenodesecoxycholic acid are used in combination, the effect of preventing the gingivitis becomes insignificant when the content is less than 0.01% by weight, and when the content is more than 1.00% No further increase in efficacy can be expected.
In addition, when triclosan is used in an amount of 0.0001% by weight or less based on the whole composition, its synergistic effect becomes insignificant. When it is used in an amount of 1.0000% by weight or more, a synergistic effect by mixing can not be expected.
The composition for enhancing oral hygiene according to the present invention is generally composed of conventional ingredients necessary for preparing a composition for enhancing oral hygiene and is composed of a mixture of urosodexoxycholic acid and chernosoxicolinic acid singly or in combination with trichlonic acid 1 < / RTI > to 100 < RTI ID = 0.0 >
More preferably, the content of urso dexoxycholic acid and chenodesoxocholic acid is 0.02 to 0.6% by weight based on the whole composition when used alone or in combination, and the mixing ratio with trichloroacid is 200: 1 to 1: 50.
The composition of the present invention can be used in an appropriate amount depending on the kind of the composition for oral use and the purpose of use such as abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, medicines, flavors, acidity regulators and whitening agents. The dentifrice composition of the present invention may contain calcium hydroxide, precipitated silica, calcium carbonate, hydrated alumina, kaolin, and high boiling (NaHCO 3 ) as abrasives. These abrasives may be used alone or as a mixture of two or more, %use.
As the wetting agent, glycerin, sorbitol, amorphous sorbitol solution, propylene glycol, polyethylene glycol, xylitol and the like are used alone or in admixture of two or more in an amount of 20 to 60% by weight based on the whole composition, preferably glycerin or amorphous The sorbitol solution and propylene glycol or polyethylene glycol are used in a weight ratio of 10 to 1 to 1 to 1 in an amount of 20 to 50% by weight.
0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight, of carrageenan, xanthan gum, carboxymethylcellulose sodium, carboxyvinyl polymer, sodium alginate, do.
Examples of the foaming agent include anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, and sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene condensation polymeric substances, etc., in an amount of 0.5 to 5.0 By weight, preferably 0.5 to 3.5% by weight. Sodium saccharin, aspartame, licorice acid and the like are used alone or in combination of two or more, and 0.05 to 0.5% by weight is used as the sweetener.
As a preservative, p-hydroxybenzoate and sodium benzoate may be used alone or in combination of two or more.
Examples of the effective agent include sodium fluoride, sodium fluorophosphate, calcium fluoride, fluorine amine, chlorhexidine, tranexamic acid, allantoin, caproic acid, bamboo salt, enzymes and herbal extracts.
As the fragrance, an appropriate amount of peppermint oil, spearmint oil, menthol, carbohydrate and the like are mixed and used. Preferably, an appropriate amount of anise oil is mixed with a certain amount of the perfume.
Examples of the acidity adjusting agent include phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartrate and the like.
The brightener is titanium oxide, suitably used in an amount of 0.1 to 2% by weight.
In particular, the composition for enhancing oral hygiene according to the present invention increases the effect of inhibiting plaque formation by mixing uricoside oxycolic acid and chernosoxicolinic acid, respectively, with triclosan in a certain ratio, Calcium phosphate monohydrate, calcium carbonate, precipitated silica, thickening, etc., as the abrasive are mixed alone or in admixture of two or more kinds to the medicinal ingredient which exhibits a good effect on the oral disease by mixing the fluorine compound or bamboo salt and the herbal medicine ingredient with the relieving prescription, (70%) and propylene glycol, polyethylene glycol or xylyltate in a weight ratio of 10 to 1 to 1 (by weight) are used as the wetting agent, glycerin or amorphous sorbitol solution (70% To 1% by weight, and as the binder, carboxymethylcellulose sodium, carrageenan alone or 0.5 to 2.0% by weight based on the total weight of the composition. Sodium lauryl sulfate and polyoxyethylene polyoxypropylene condensation polymeric materials are used singly or in combination as a foaming agent. When they are mixed, 1.0 to 1.0 To about 3.5% by weight, and as the fragrance, a certain amount of peppermint oil, spearmint oil, menthol, carbohydrate and the like are mixed and used in an appropriate amount, more preferably anise oil is mixed and used. The acidity adjusting agent is phosphoric acid, phosphoric acid It is preferable to adjust the acidity to 6.0 to 8.0 by using sodium, citric acid and sodium citrate, and to use 0.1 to 1.0% by weight of titanium oxide as the brightener.
The composition for enhancing oral hygiene of the present invention may be prepared by using an appropriate amount of a component commonly used in the product and mixing the product of urosodexoxycholic acid and chess deoxycolic acid singly or in combination with trichlonic acid Is used.
The composition for enhancing oral hygiene according to the present invention can be effectively used as toothpaste, oral cleaning agent, denture cleansing agent, chewing gum and oral massage cream (ointment).
Hereinafter, the present invention will be described in detail with reference to examples and comparative examples, but the technical scope of the present invention is not limited to these examples.
Examples 1 to 7 and Comparative Examples 1 to 3 The dentifrice compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 1 below. First, powder components such as carboxymethylcellulose sodium, saccharin and preservative were dispersed in a sorbitol solution as a wetting component, diluted with purified water, and then mixed in a mixer, and then an abrasive such as calcium monohydrogenphosphate and a medicinal agent were added and mixed .
Finally, a dentifrice composition was prepared by adding sodium alkylsulfate as a foaming agent, stabilizers and perfume ingredients and mixing under vacuum.
Experimental Example 1
1) Subject of the experiment
Ursoidesoxycolic acid, chenodesecoxycholic acid, and trichroic acid
2) Experimental method
end. The test strain (S. mutans 10449, type C) is cultured in a brain-heart infusion agar, and the bacteria are inoculated into a THB (Hodd Hewite Broth) and cultured at 37 ° C for 15 hours.
I. Sterilize the small glass rod and measure its weight.
All. Place the glass rod in a test tube containing sucrose, add the test substance at a certain concentration, add the test strain, and incubate at 37 ° C for 24 hours.
la. After incubation, the glass rod is carefully lifted and dried at 37 ° C for one day, and the final weight is measured. The control group is the test group to which the test substance is not added.
hemp. (Calculation)
3) Experimental results (Table 2)
As can be seen from the above Table 2, it was found that the dentifrice composition in which urushodesoxycric acid and chenodesecoxycholic acid were mixed together or mixed together in a proper ratio with tricalylane significantly increased plaque formation inhibitory effect.
Experimental Example 2
Experiments to inhibit plaque formation by using the dentifrice compositions of Examples 1 to 7 and Comparative Examples 1 to 3 in Table 1 and experiments to inhibit the formation of gingival inflammation were carried out.
1) Experimental method
① After screening the subject, explain about oral examination.
② Quite-Hein Index modified by Turesky and Gingival Bleeding Index (Loe-Silness Index) were administered to each of the patients and the subjects of the study. ).
③ Scale the entire teeth of the experimental group.
④ After using the control toothpaste for 2 weeks, a dental checkup was performed. At this time, the plaque index and the gingival index were used as initial values.
⑤ Example The toothpaste and the comparative toothpaste were given to each subject, and toothbrushing was performed in the same manner as usual 3 times a day for 4 weeks, and oral examination was performed for 2 weeks and 4 weeks to score the plaque index and gingivitis index.
⑥ The test results were compared with the initial values of the experimental group and the scores after 4 weeks, and the statistical significance was tested by T-test.
2) Experimental results
(1) plaque index
(2) Gingival Index
3) Discussion
(1) The dentifrice compositions of Examples 1 to 7 and Comparative Examples 1 to 3 were tested for statistical significance by measuring the plaque index after using for 4 weeks. As a result, To 3, it was confirmed that there was a significant effect both before and after use, and it was confirmed that uricosideoxycholic acid or chernosoxoxycholic acid alone or mixed and triclosan mixed at a certain ratio had a content of 0.02 to 1.00 It was found that the effect of suppressing the formation of plaque was good in the toothpaste prescription in which the percentage by weight of triclosan and the amount of triclosan in the range of 0.0001 to 1.0000% by weight were mixed.
In particular, as shown in Example 5 and Comparative Example 2, it was found that the effect of suppressing the formation of plaque was significantly improved by using a mixture of ursodeoxycholic acid at a certain ratio, as compared with the case of using triclosan alone.
(2) The gingival index after the use of the dentifrice compositions of Examples 1 to 7 and Comparative Examples 1 to 3 was measured for statistical significance after four weeks of use. As a result, in Examples 1 to 7 and Comparative Examples 2 to 3, 3 showed significant effects both before and after use. Ursodexoxycholic acid or chernodesoxycholic acid alone or in combination with triclosan in a certain ratio and its content ranged from 0.02 to 1.00 weight % Or more and triclosan in a range of 0.001 to 1.0000% by weight in the case of toothpaste prescription.
In particular, as shown in Example 5 and Comparative Example 2, the toothpaste of the Example in which urushodesuoxycholic acid was mixed in a certain ratio was more effective than the triacic acid alone in mitigating the gingivitis, It turned out to be good.
Example 8
Oral cleanser
Ethanol 10.00%
Polyoxyethylene polyoxypropylene copolymer 1.00%
Concentrated glycerin 15.00%
Saccharin sodium 0.01%
0.02% Ursodesoxycolic acid
Tricloric acid 0.20%
Sodium fluoride 0.23%
Fragrance 0.30%
Purified water was added to 100.00%
Example 9
Chewing gum
Gum base 25.00%
Sorbitol 44.00%
Mannitol 12.00%
Glycerin 13.00%
Lecithin 0.50%
Sweetener 2.00%
0.02% Ursodesoxycolic acid
Tricaric acid 0.0001%
Fragrance 1.00%
Example 10
Gum Massage Cream (Ointment)
Glycerin monolauryl 3.00%
Fly alcohol 5.00%
Polyethylene glycol 15.00%
White Wasserin 3.00%
N-palmitic acid monosodium glutamate 0.50%
Hydroxyethylcellulose 5.00%
Tocopheryl acetate 0.10%
Ursode desoxycholic acid 0.20%
0.10%
Sweetener 0.20%
Fragrance 0.30%
Purified water was added to 100.0%
In Examples 8 to 10, the anti-plaque formation effect and the gingival inflammation relaxation effect were excellent.
Therefore, the composition for promoting oral hygiene according to the present invention is very useful industrially since it has an excellent effect of suppressing the formation of plaque and the effect of alleviating gingivitis.
The present invention relates to a composition for promoting oral hygiene which is effective for prevention of periodontal disease, treatment and prevention of tooth decay. More particularly, the present invention relates to a composition for enhancing oral hygiene which is effective for prevention of periodontal disease by applying the action of collangease, ursodesoxycholic acid ) And / or chenodeoxycholic acid (steroids) with excellent sterilization effect, thereby preventing the plaque (plaque) and preventing and treating periodontal disease, and by containing triclosan, And a composition for promoting oral hygiene that can provide a plaque formation inhibiting effect.
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1019960027844A KR980008203A (en) | 1996-07-10 | 1996-07-10 | Composition for promoting oral hygiene |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1019960027844A KR980008203A (en) | 1996-07-10 | 1996-07-10 | Composition for promoting oral hygiene |
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Publication Number | Publication Date |
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KR980008203A true KR980008203A (en) | 1998-04-30 |
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Family Applications (1)
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KR1019960027844A KR980008203A (en) | 1996-07-10 | 1996-07-10 | Composition for promoting oral hygiene |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010104875A (en) * | 2000-05-16 | 2001-11-28 | 성재갑 | Composition for enhancing oral hygiene |
KR100453351B1 (en) * | 1996-07-25 | 2005-04-19 | 주식회사 엘지생활건강 | Oral Hygiene Composition |
KR100519477B1 (en) * | 1998-08-01 | 2005-12-14 | 주식회사 엘지생활건강 | Periodontal disease prevention and treatment composition containing trichromic acid, urodessoxycholine acid derivative and milky skin extract |
-
1996
- 1996-07-10 KR KR1019960027844A patent/KR980008203A/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100453351B1 (en) * | 1996-07-25 | 2005-04-19 | 주식회사 엘지생활건강 | Oral Hygiene Composition |
KR100519477B1 (en) * | 1998-08-01 | 2005-12-14 | 주식회사 엘지생활건강 | Periodontal disease prevention and treatment composition containing trichromic acid, urodessoxycholine acid derivative and milky skin extract |
KR20010104875A (en) * | 2000-05-16 | 2001-11-28 | 성재갑 | Composition for enhancing oral hygiene |
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