KR980002098A - Polylactic Acid and Manufacturing Method Thereof - Google Patents

Polylactic Acid and Manufacturing Method Thereof Download PDF

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Publication number
KR980002098A
KR980002098A KR1019960022245A KR19960022245A KR980002098A KR 980002098 A KR980002098 A KR 980002098A KR 1019960022245 A KR1019960022245 A KR 1019960022245A KR 19960022245 A KR19960022245 A KR 19960022245A KR 980002098 A KR980002098 A KR 980002098A
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KR
South Korea
Prior art keywords
lactic acid
polylactic acid
weight
oligomer
producing
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Application number
KR1019960022245A
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Korean (ko)
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KR100190230B1 (en
Inventor
오상균
위상백
김준영
이준희
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김상응
주식회사 삼양사
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Priority to KR1019960022245A priority Critical patent/KR100190230B1/en
Publication of KR980002098A publication Critical patent/KR980002098A/en
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Publication of KR100190230B1 publication Critical patent/KR100190230B1/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/85—Germanium, tin, lead, arsenic, antimony, bismuth, titanium, zirconium, hafnium, vanadium, niobium, tantalum, or compounds thereof
    • C08G63/86—Germanium, antimony, or compounds thereof
    • C08G63/866—Antimony or compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/10—Esters; Ether-esters
    • C08K5/101—Esters; Ether-esters of monocarboxylic acids
    • C08K5/105—Esters; Ether-esters of monocarboxylic acids with phenols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

본 발명은 생분해성 고분자인 폴리락트산을 락트산으로 부터 직접 탈수 축합반응에 의해 제조하는 방법에 관한 신규한 발명으로 의료용 재료나 범용 수지 대체물로 사용할 수 있는 폴리락트산에 관한 것으로, 그 기술구성은 락트산을 삼산화안티몬 또는 산화제1주석 등과 함께 반응기내에서 탈수 및 중축합 반응을 시켜 락트산 올리고머를 얻고, 이 락트산 올리고머를 클로로포름 또는 메틸렌 클로라이드에 녹인 다음 메탄올에 침지시키거나, 직접 이소프로필에테르로 정제하여 미반응 락트산과 수분을 제거하고 건조된 락트산 올리고머를 감압상태에서 촉매와 산화방지제의 존재하에서 다시 중축합시킴을 특징으로 하는 폴리락트산의 제조방법에 관한 것이다.The present invention relates to a polylactic acid which can be used as a medical material or a general-purpose resin substitute by a novel invention for producing a polylactic acid, a biodegradable polymer, by direct dehydration condensation reaction from lactic acid. Dehydration and polycondensation reaction in the reactor with antimony trioxide or stannous oxide to obtain lactic acid oligomer, which is dissolved in chloroform or methylene chloride and then immersed in methanol, or directly purified with isopropyl ether to give unreacted lactic acid. The present invention relates to a method for producing polylactic acid characterized by removing water and moisture and polycondensing the dried lactic acid oligomer in the presence of a catalyst and an antioxidant under reduced pressure.

Description

폴리락트산 및 그 제조방법Polylactic Acid and Manufacturing Method Thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

락트산을 1차로 탈수 및 중축합 반응시켜 락트산 올리고머를 얻은 다음 2차로 다시 중축합 반응시키는 것을 특징으로 하는 폴리락트산의 제조방법.A method for producing polylactic acid, characterized in that lactic acid is first dehydrated and subjected to polycondensation reaction to obtain lactic acid oligomer, and then secondly polycondensation reaction. 제1항에 있어서, 1차 및 2차 중축합 반응시에 촉매로 락트산 또는 락트산 올리고머 100중량%에 대하여 0.0005~5중량%를 사용하는 것을 특징으로 하는 폴리락트산의 제조방법.The method for producing polylactic acid according to claim 1, wherein 0.0005 to 5% by weight based on 100% by weight of lactic acid or lactic acid oligomer is used as a catalyst during the first and second polycondensation reactions. 제1항에 있어서, 2차 중축합 반응시 산화방지제로 락트산 올리고머 100중량%에 대하여 0.0001~5중량% 사용하는 것을 특징으로 하는 폴리락트산의 제조방법.The method for producing polylactic acid according to claim 1, wherein the antioxidant is used in an amount of 0.0001 to 5% by weight based on 100% by weight of lactic acid oligomer as an antioxidant during the secondary polycondensation reaction. 제1항에 있어서, 중량평균 분자량인 30,000이상인 락트산 올리고머를 사용하는 것을 특징으로 하는 폴리락트산의 제조방법.The method for producing polylactic acid according to claim 1, wherein a lactic acid oligomer having a weight average molecular weight of 30,000 or more is used. 제1항 또는 제4항에 있어서, 락트산 올리고머가 미반응 락트산 함량을 0.5중량% 이하를 포함하고 있는 것을 특징으로 하는 폴리락트산의 제조방법.The method for producing polylactic acid according to claim 1 or 4, wherein the lactic acid oligomer contains 0.5% by weight or less of unreacted lactic acid content. 제조된 폴리락트산의 분자량이 30,000~250,000인 것을 특징으로 하는 폴리락트산.Polylactic acid, characterized in that the molecular weight of the produced polylactic acid is 30,000 ~ 250,000. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960022245A 1996-06-19 1996-06-19 Process for preparing polylactic acid KR100190230B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960022245A KR100190230B1 (en) 1996-06-19 1996-06-19 Process for preparing polylactic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960022245A KR100190230B1 (en) 1996-06-19 1996-06-19 Process for preparing polylactic acid

Publications (2)

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KR980002098A true KR980002098A (en) 1998-03-30
KR100190230B1 KR100190230B1 (en) 1999-06-01

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020022160A (en) * 2000-09-19 2002-03-27 이찬우 Melt/Solid Polycondensation of L-Lactic Acid:An Alternative Route to Poly(L-lactic acid)with High Molecular Weight
JP2005505675A (en) * 2001-10-18 2005-02-24 サムヤン コーポレイション PH-responsive biodegradable polylactic acid derivatives forming polymeric micelles and use of such derivatives in poorly soluble drug carriers

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