KR970070011A - A new method for producing beta-ketophosphonates - Google Patents

A new method for producing beta-ketophosphonates Download PDF

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Publication number
KR970070011A
KR970070011A KR1019960012072A KR19960012072A KR970070011A KR 970070011 A KR970070011 A KR 970070011A KR 1019960012072 A KR1019960012072 A KR 1019960012072A KR 19960012072 A KR19960012072 A KR 19960012072A KR 970070011 A KR970070011 A KR 970070011A
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KR
South Korea
Prior art keywords
general formula
compound
compound represented
producing
iii
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KR1019960012072A
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Korean (ko)
Inventor
정인창
윤길중
이병광
공면식
김대영
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서치영
주식회사 대웅제약
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Application filed by 서치영, 주식회사 대웅제약 filed Critical 서치영
Priority to KR1019960012072A priority Critical patent/KR970070011A/en
Publication of KR970070011A publication Critical patent/KR970070011A/en

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Abstract

본 발명은 일반식(Ⅱ) 화합물과 일반식(Ⅲ) 화합물을 반응시킴으로써 하기의 일반식(Ⅰ) 화합물인 베타-케토포스포네이트를 제조하는 신규한 제조방법에 관한 것이다.The present invention relates to a novel process for producing beta-ketophosphonate, which is a compound represented by the following general formula (I), by reacting a compound represented by the general formula (II) with a compound represented by the general formula (III).

본 발명은 선행기술에 비하여 첫째, 일반식(Ⅱ) 화합물과 일반식(Ⅲ) 화합물간의 반응이 온화하여 반응성을 줄이기 위하여 중금속인 구리등을 사용할 필요가 없으며, 둘재, 부생성물이 생성되지 않으며, 셋째, 상온에서 반응이 진행되기 때문에 산업적으로 매우 유용하며, 네째, 치환기의 종류에 따른 반응성의 차이도 적으며, 다섯째, 수율이 90~92%로서 매우 높다는 장점을 제공한다.In contrast to the prior art, the present invention is characterized in that, firstly, there is no need to use heavy metal copper or the like in order to milden the reaction between the general formula (II) compound and the general formula (III) compound, Third, since the reaction proceeds at room temperature, it is industrially very useful. Fourth, the reactivity varies little depending on the type of substituent. Fifth, the yield is 90 to 92%, which is very high.

Description

베타-케토포스포네이트의 신규한 제조방법A new method for producing beta-ketophosphonates

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (6)

하기 일반식(Ⅱ) 화합물과 일반식(Ⅲ) 화합물을 반응시켜 일반식(Ⅰ) 화합물을 제조하는 방법.A process for producing a compound of the general formula (I) by reacting a compound represented by the following general formula (II) with a compound represented by the general formula (III). 상기 식에서, R1은 탄소수 1~4의 저급알킬기이며, R2은 탄소수 1~7의 알킬기 또는 페닐, 페녹시 메틸기이며, X는 염소, 브롬, 또는 요오드와 같은 할로겐 원자이다.Wherein R 1 is a lower alkyl group having 1 to 4 carbon atoms, R 2 is an alkyl group having 1 to 7 carbon atoms or a phenyl or phenoxymethyl group, and X is a halogen atom such as chlorine, bromine, or iodine. 제1항에 있어서, R2가 탄소수 5개의 펜틸기 또는 페녹시 메틸기임을 특징으로 하는 일반식(Ⅰ) 화합물을 제조하는 방법.The process for producing a compound represented by the general formula (I) according to claim 1, wherein R 2 is a pentyl group or a phenoxymethyl group having 5 carbon atoms. 제1항에 있어서, 할로겐화 금속염을 사용하는 것을 특징으로 하는 일반식(Ⅰ) 화합물을 제조하는 방법.The method of claim 1, wherein a halogenated metal salt is used. 제1항에 있어서, 트리에틸아민을 일반식(Ⅱ) 화합물에 대하여 3.0~5.0당량비를 사용함을 특징으로 하는 일반식(Ⅰ) 화합물을 제조하는 방법.The method for producing a compound of general formula (I) according to claim 1, wherein triethylamine is used in an amount of 3.0 to 5.0 equivalents based on the compound (II). 제1항에 있어서, 반응온도가 0~50℃임을 특징으로 하는 일반식(Ⅰ) 화합물을 제조하는 방법.The method according to claim 1, wherein the reaction temperature is 0 to 50 占 폚. 제1항 및 제3항에 있어서, 염화마그네슘을 일반식(Ⅱ) 화합물에 대하여 1.0~1.5당량비를 사용함을 특징으로 하는 일반식(Ⅰ) 화합물을 제조하는 방법.The method for producing the compound of general formula (I) according to any one of claims 1 to 3, wherein magnesium chloride is used in an amount of 1.0 to 1.5 equivalents based on the compound of the general formula (II). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960012072A 1996-04-20 1996-04-20 A new method for producing beta-ketophosphonates KR970070011A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960012072A KR970070011A (en) 1996-04-20 1996-04-20 A new method for producing beta-ketophosphonates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960012072A KR970070011A (en) 1996-04-20 1996-04-20 A new method for producing beta-ketophosphonates

Publications (1)

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KR970070011A true KR970070011A (en) 1997-11-07

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KR1019960012072A KR970070011A (en) 1996-04-20 1996-04-20 A new method for producing beta-ketophosphonates

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