KR970064625A - Method for producing chitin-based interpenetrating structure film for artificial skin - Google Patents

Method for producing chitin-based interpenetrating structure film for artificial skin Download PDF

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Publication number
KR970064625A
KR970064625A KR1019960006788A KR19960006788A KR970064625A KR 970064625 A KR970064625 A KR 970064625A KR 1019960006788 A KR1019960006788 A KR 1019960006788A KR 19960006788 A KR19960006788 A KR 19960006788A KR 970064625 A KR970064625 A KR 970064625A
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South Korea
Prior art keywords
chitin
weight
artificial skin
lactide
caprolactone
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KR1019960006788A
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Korean (ko)
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KR0161648B1 (en
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이영무
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이영무
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Publication of KR0161648B1 publication Critical patent/KR0161648B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 인공피부용 키틴계 상호침투구조 필름의 제조방법에 관한 것으로, 좀 더 상세하게는 키틴 10~90중량%와 D,L-락타이드 또는 ε-카프로락톤과 분자량이 100~20,000인 폴리에틸렌글리콜 마크로머로 이루어진 지방족 폴리에스테르 10~90중량%를 유기용매 존재하에서 반응시킨 다음, 상기 반응물에 자외선 경화촉진제를 첨가시켜 10~120분간 자외선 경화시키는 인공피부용 키틴계 상호침투구조 필름의 제조방법에 관한 것이다. 상기 필름은 키틴에 습윤시 강도를 보강하고, 생분해성이 향상된 분해흡수성 인공피부 또는 수술용 봉합사로 사용가능하다.More particularly, the present invention relates to a process for producing a chitin-based interpenetrating structure film for artificial skin, which comprises 10 to 90% by weight of chitin, D, L-lactide or epsilon -caprolactone and 100 to 20,000 polyethylene glycol The present invention relates to a process for producing a chitin-based interpenetrating structure film for artificial skin, which comprises reacting 10 to 90% by weight of an aliphatic polyester comprising a macromer in the presence of an organic solvent, and then adding an ultraviolet curing accelerator to the reaction product for 10 to 120 minutes will be. The film can be used as a biodegradable bioabsorbable artificial skin or a surgical suture reinforcing the strength upon wetting of chitin.

Description

인공피부용 키틴계 상호침투구조 필름의 제조방법Method for producing chitin-based interpenetrating structure film for artificial skin

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (10)

키틴 10~90중량%와 D,L-락타이드 또는 ε-카프로락톤과 분자량이 100~20,000인 폴리에틸렌글리콜 마크로머로 이루어진 지방족 폴리에스테르 10~90중량%를 유기용매 존재하에서 반응시킨 다음, 상기 반응물에 자외선 경화촉진제를 첨가시켜 10~120분간 자외선 경화시키는 것을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.10 to 90% by weight of chitin and 10 to 90% by weight of an aliphatic polyester comprising D, L-lactide or? -Caprolactone and a polyethylene glycol macromer having a molecular weight of 100 to 20,000 are reacted in the presence of an organic solvent, Wherein the ultraviolet curing accelerator is added to the ultraviolet curing accelerator for 10 to 120 minutes. 제1항에 있어서, 상기 키틴이 α-키틴, β-키틴 또는 γ-키틴인 것을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The method according to claim 1, wherein the chitin is? -Chine,? -Chine or? -Chine. 제1항에 있어서, 상기 폴리에틸렌글리콜 마크로머가 폴리에틸 렌글리콜디메타크릴레이트, 폴리에테르디메타크릴레이트, 폴리프로필 렌글리콜디메타크릴레이트 또는 폴리에스테르디메타크릴레이트임을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The chitin system for artificial skin according to claim 1, wherein the polyethylene glycol macromer is polyethyleneglycol dimethacrylate, polyether dimethacrylate, polypropylene glycol dimethacrylate or polyester dimethacrylate A method of making a film of interpenetrating structure. 제1항에 있어서, 상기 유기용매가 포름산, 아세트산, 황산, 염산 또는 삼불화아세트산암을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The method according to claim 1, wherein the organic solvent is characterized by formic acid, acetic acid, sulfuric acid, hydrochloric acid or acetic acid trifluoroacetate. 제1항에 있어서, 상기 자외선 경화촉진제가 벤조페논, 아세토페논, 안트라퀴논, 잔톤, 캄포퀴논, 플르오레논 또는 이들의 유도체임을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The method according to claim 1, wherein the ultraviolet curing accelerator is benzophenone, acetophenone, anthraquinone, xanthone, camphorquinone, fluorenone, or derivatives thereof. 제1항에 있어서, 상기 자외선 경화촉진제가 상기 반응물의 고형분 100중량부에 대해 15~35중량부의 양으로 유기용매에 용해시켜 첨가됨을 특징으로 하는 인공피부용 키틴계 상호 침투구조 필름의 제조방법.The method according to claim 1, wherein the ultraviolet curing accelerator is added in an amount of 15 to 35 parts by weight based on 100 parts by weight of the solid content of the reactant in an organic solvent. 제6항에 있어서, 상기 유기용매가 N-비닐피롤리돈, N-메틸피롤리돈, 디메틸포름아미드, 디메틸아세트아미드 또는 디메틸술폭사이드임을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.7. The process for producing a chitin-based interpenetrating structure film for artificial skin according to claim 6, wherein the organic solvent is N-vinylpyrrolidone, N-methylpyrrolidone, dimethylformamide, dimethylacetamide or dimethylsulfoxide . 제1항에 있어서, 상기 D,L-락타이드 또는 ε-카프로락톤이 폴리에틸렌글리콜 마크로머보다 과량 첨가됨을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The method according to claim 1, wherein the D, L-lactide or? -Caprolactone is added in an excess amount over the polyethylene glycol macromer. 제1항에 있어서, 상기 D,L-락타이드 또는 ε-카프로락톤이 폴리에틸렌글리콜 마크로머의 혼합물비가 5:1임을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The method of claim 1, wherein the mixing ratio of the D, L-lactide or? -Caprolactone to the polyethylene glycol macromer is 5: 1. 제1항 또는 제8항에 있어서, 상기 D,L-락타이드 또는 ε-카프로락톤이 폴리에틸렌글리콜 마크로머의 반응이 스테너스 옥테이트, 트리플루오로메탄술폰산, 염화철, 염화아연 또는 아세틸퍼클로레이트와 같은 반응개시체의 존재하에서 반응됨을 특징으로 하는 인공피부용 키틴계 상호침투구조 필름의 제조방법.The process according to claim 1 or 8, wherein said D, L-lactide or? -Caprolactone is selected from the group consisting of styrene, Wherein the reaction product is reacted in the presence of a reaction initiator. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960006788A 1996-03-12 1996-03-12 Method for producing artificial skin-film KR0161648B1 (en)

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KR0161648B1 KR0161648B1 (en) 1999-01-15

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