KR970058722A - Peptides with antifungal activity - Google Patents

Peptides with antifungal activity Download PDF

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Publication number
KR970058722A
KR970058722A KR1019960001911A KR19960001911A KR970058722A KR 970058722 A KR970058722 A KR 970058722A KR 1019960001911 A KR1019960001911 A KR 1019960001911A KR 19960001911 A KR19960001911 A KR 19960001911A KR 970058722 A KR970058722 A KR 970058722A
Authority
KR
South Korea
Prior art keywords
peptide
peptides
amino acid
antifungal activity
integer
Prior art date
Application number
KR1019960001911A
Other languages
Korean (ko)
Other versions
KR100308863B1 (en
Inventor
오종은
이건형
홍성유
조현숙
이복률
정광회
윤정혁
문홍모
Original Assignee
허영섭
재단법인 목암생명공학연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 허영섭, 재단법인 목암생명공학연구소 filed Critical 허영섭
Priority to KR1019960001911A priority Critical patent/KR100308863B1/en
Priority to PCT/KR1996/000034 priority patent/WO1997002286A1/en
Priority to US08/700,449 priority patent/US5889148A/en
Priority to AU49571/96A priority patent/AU4957196A/en
Publication of KR970058722A publication Critical patent/KR970058722A/en
Application granted granted Critical
Publication of KR100308863B1 publication Critical patent/KR100308863B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 항진균(antfun) 활성을 갖는 화학합성 펩타이드에 관한 것이다. 본 발명의 펩타이드는 매우 높은 활성을 나타내고, 그의 대량생산이 용이하여 경제적이며, 인체에 사용할 경우 세포파괴 등의 부작용이 적으므로, 의약용 또는 각종 생활용품 항진균제로 이용될 수 있다.The present invention relates to chemically synthesized peptides having antifunct activity. The peptides of the present invention exhibit very high activity, are easy to mass-produce and are economical, and when used in the human body, there are few side effects such as cell destruction, and thus they can be used as antifungal agents for medicines or various household products.

Description

항진균 활성을 갖는 펩타이드Peptides with antifungal activity

내용없음No content

Claims (3)

하기 일방식(I)로 표시되는 항진균 활성을 갖는 펩타이드;A peptide having an antifungal activity represented by the following formula (I); X1(AB)n1(BA)n2C X2(I) X 1 (AB) n1 (BA ) n2 CX 2 (I) 상기에서, X1은 1 내지 4개의 아미노산이고; A는 하나의 소수성 방향족 아미노산(hydrophobic amino acid)이며; B는 하나의 소수성 지방족 아미노산 (hydrophobic aliphatic amino acid)이고; n1은 1 또는 2의 정수이며; n2는 1,2 또는 3의 정수이고, (단, n1이 1인 경우, n2는 또는 3이어야 하고, n1가 2인 경우, n2는 1 또는 2이어야 한다); C는 없거나, 하나의 소수성 아미노산이며; 및, X2는 하나 또는 두개의 염기성 아미노산(basic amino acid)이다.Wherein X 1 is one to four amino acids; A is a hydrophobic amino acid; B is a hydrophobic aliphatic amino acid; n1 is an integer of 1 or 2; n2 is an integer of 1, 2 or 3 (provided that when n1 is 1, n2 must be 3 or n1 is 2, n2 must be 1 or 2); C is absent or is a single hydrophobic amino acid; And X 2 is one or two basic amino acids. 제1항에 있어서, 펩타이드는 화학적으로 합성되거나 유전공학적으로 방법으로 제조되는 것을 특징으로 하는 항진균 활성을 갖는 펩타이드.The peptide according to claim 1, wherein the peptide is chemically synthesized or produced by a genetic engineering method. 제1항 기재의 펩타이드를 유효성분으로 하고, 약학적으로 허용되는 담체를 포함하는 항진균제 조성물.An antifungal agent composition comprising the peptide of claim 1 as an active ingredient and a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960001911A 1995-07-06 1996-01-29 Peptide having antifungal activity KR100308863B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019960001911A KR100308863B1 (en) 1996-01-29 1996-01-29 Peptide having antifungal activity
PCT/KR1996/000034 WO1997002286A1 (en) 1995-07-06 1996-03-11 Novel antibiotic peptides
US08/700,449 US5889148A (en) 1995-07-06 1996-03-11 Antibiotic peptides
AU49571/96A AU4957196A (en) 1995-07-06 1996-03-11 Novel antibiotic peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960001911A KR100308863B1 (en) 1996-01-29 1996-01-29 Peptide having antifungal activity

Publications (2)

Publication Number Publication Date
KR970058722A true KR970058722A (en) 1997-08-12
KR100308863B1 KR100308863B1 (en) 2001-12-17

Family

ID=37530669

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960001911A KR100308863B1 (en) 1995-07-06 1996-01-29 Peptide having antifungal activity

Country Status (1)

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KR (1) KR100308863B1 (en)

Also Published As

Publication number Publication date
KR100308863B1 (en) 2001-12-17

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