KR970058721A - Peptides with antibacterial and antifungal activity - Google Patents

Peptides with antibacterial and antifungal activity Download PDF

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Publication number
KR970058721A
KR970058721A KR1019960001910A KR19960001910A KR970058721A KR 970058721 A KR970058721 A KR 970058721A KR 1019960001910 A KR1019960001910 A KR 1019960001910A KR 19960001910 A KR19960001910 A KR 19960001910A KR 970058721 A KR970058721 A KR 970058721A
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KR
South Korea
Prior art keywords
amino acids
antibacterial
peptide
antifungal activity
peptides
Prior art date
Application number
KR1019960001910A
Other languages
Korean (ko)
Other versions
KR100308862B1 (en
Inventor
조현숙
이건형
홍성유
이복률
정광회
윤정혁
오종은
문홍모
Original Assignee
허영섭
재단법인 목암생명공학연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 허영섭, 재단법인 목암생명공학연구소 filed Critical 허영섭
Priority to KR1019960001910A priority Critical patent/KR100308862B1/en
Priority to US08/700,449 priority patent/US5889148A/en
Priority to PCT/KR1996/000034 priority patent/WO1997002286A1/en
Priority to AU49571/96A priority patent/AU4957196A/en
Publication of KR970058721A publication Critical patent/KR970058721A/en
Application granted granted Critical
Publication of KR100308862B1 publication Critical patent/KR100308862B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 항균(antibacterial) 및 항진균(antifungal) 활성을 갖는 화학합성 펩타이드에 관한 것이다. 본 발명의 펩타이드는 매우 높이 항균 및 항진균 활성을 나타내고, 그의 대량생산이 용이하여 경제적이며, 인체에 사용할 경우 세포파괴 등의 부작용이 적으므로, 의약용 또는 각종 생활용품용 항균제 및 항진균제로 이용될 수 있다.The present invention relates to chemically synthesized peptides having antibacterial and antifungal activity. The peptides of the present invention exhibit very high antibacterial and antifungal activity, are economical because they are easy to mass-produce, and can be used as antimicrobial agents and antifungal agents for medicines or various daily necessities since they have few side effects such as cell destruction have.

Description

항균 및 항진균 활성을 갖는 펩타이드Peptides with antimicrobial and antifungal activity

내용없음No content

Claims (4)

하기 일반식(I)로 표시되는 항균 및 항진균 활성을 갖는 페타이드;A pedestal having antibacterial and antifungal activity represented by the following general formula (I); X1X2X3X4X5(I)X 1 X 2 X 3 X 4 X 5 (I) 상기에서, X1은 1내지 4개의 아미노산이고; X2는 2 내지 4개의 소수성 아미노산(hydrophobic amino acid)이며, X3는 하나 또는 두개의 염기성 아미노산(basic amino acid)이고; X4는 2 내지 4개의 소수성 아미노산이며; 및, X5는 최소한 1개 이상의 염기성 아미노산을 포함하는 1 내지 3개의 아미노산이다(단, 2개 이상의 아미노산으로 구성되는 경우, 염기성 아미노산이 N-말단에 위치하다).Wherein X 1 is one to four amino acids; X 2 is 2 to 4 hydrophobic amino acids, X 3 is one or two basic amino acids; X 4 is 2 to 4 hydrophobic amino acids; And X 5 is one to three amino acids including at least one basic amino acid (provided that at least two basic amino acids are located at the N-terminal). 제1항에 있어서, 펩타이드는 화학적으로 합성되는 유전공학적 방법으로 제조되는 것을 특징으로 하는 항균 및 항진균 활성을 갖는 펩타이드.2. The peptide of claim 1, wherein the peptide is produced by a genetically engineered method that is chemically synthesized. 제1항 기재의 펩타이드를 유효성분으로 하고, 약학적으로 허용되는 담체를 포함하는 항균제 조성물.An antimicrobial agent composition comprising the peptide of claim 1 as an active ingredient and a pharmaceutically acceptable carrier. 제1항 기재의 펩타이드를 유효성분으로 하고, 약학적 허용되는 담체를 포함하는 항진균제 조성물.An antifungal agent composition comprising the peptide of claim 1 as an active ingredient and a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960001910A 1995-07-06 1996-01-29 Peptide having antibacterial and antifungal activity KR100308862B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019960001910A KR100308862B1 (en) 1996-01-29 1996-01-29 Peptide having antibacterial and antifungal activity
US08/700,449 US5889148A (en) 1995-07-06 1996-03-11 Antibiotic peptides
PCT/KR1996/000034 WO1997002286A1 (en) 1995-07-06 1996-03-11 Novel antibiotic peptides
AU49571/96A AU4957196A (en) 1995-07-06 1996-03-11 Novel antibiotic peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960001910A KR100308862B1 (en) 1996-01-29 1996-01-29 Peptide having antibacterial and antifungal activity

Publications (2)

Publication Number Publication Date
KR970058721A true KR970058721A (en) 1997-08-12
KR100308862B1 KR100308862B1 (en) 2001-12-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960001910A KR100308862B1 (en) 1995-07-06 1996-01-29 Peptide having antibacterial and antifungal activity

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KR (1) KR100308862B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101303299B1 (en) * 2010-10-08 2013-09-03 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 Novel use of antimicrobial peptides for wound-healing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101303299B1 (en) * 2010-10-08 2013-09-03 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 Novel use of antimicrobial peptides for wound-healing

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Publication number Publication date
KR100308862B1 (en) 2001-12-17

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