KR970042559A - Simple Method of Making Cemfe Derivatives - Google Patents

Simple Method of Making Cemfe Derivatives Download PDF

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Publication number
KR970042559A
KR970042559A KR1019950055057A KR19950055057A KR970042559A KR 970042559 A KR970042559 A KR 970042559A KR 1019950055057 A KR1019950055057 A KR 1019950055057A KR 19950055057 A KR19950055057 A KR 19950055057A KR 970042559 A KR970042559 A KR 970042559A
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KR
South Korea
Prior art keywords
formula
compound
methyl group
chloride
methyl
Prior art date
Application number
KR1019950055057A
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Korean (ko)
Inventor
최영진
정교덕
김재훈
김봉석
김태훈
Original Assignee
김사웅
국제약품공업주식회사
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Priority to KR1019950055057A priority Critical patent/KR970042559A/en
Publication of KR970042559A publication Critical patent/KR970042559A/en

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Abstract

본 발명은 트리페닐포스핀((C6H5)3P)을 출발물질로하여 이것을 사염화탄소(CCL4)로 처리하여 트리페닐클로로메틸포스포늄 클로라이드 ((C6H5)3P+CCL3)(CL-)를 만들고, 분리과정 없이 바로 구조식(2) 화합물과 반응시켜 구조식(3)의 트리아릴아실옥시포스포늄클로라이드를 재조하고, 이 화합물을 구조식(4)에 대응하는 산클로라이드로 전환한 후, 이들을 구조식(5)의 화합물과 반응시킴으로서 목적하는 구조식(1)의 아실화물을 높은 수율로 재조하는 방법에 관한 것이다.The present invention treats triphenylphosphine ((C 6 H 5 ) 3 P) as a starting material and treats it with carbon tetrachloride (CCL 4 ) to give triphenylchloromethylphosphonium chloride ((C 6 H 5 ) 3 P + CCL 3 ) To form a (CL-) and react with the compound of formula (2) immediately without separation to prepare triarylacyloxyphosphonium chloride of formula (3), and convert the compound to the acid chloride corresponding to formula (4). Thereafter, the present invention relates to a method for preparing the acyl compound of the desired structural formula (1) in high yield by reacting them with the compound of the structural formula (5).

Description

세펨 유도체의 간단한 제조방법Simple Method of Making Cemfe Derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

트리페닐포스핀과 사염화탄소를 반응시켜 트리페닐클로로메틸포스포늄 클로라이드를 제조하고 이 화합물을 구조식(2) 화합물과 반응시켜 트리페닐아실옥시포스포늄 클로라이드 유도체를 거쳐 구조식(4)의 산클로라이드로 변화시킨 후 구조식(5)의 아민 화합물과 반응시킴을 특징으로 하는 구조식(1)의 세펨 유도체의 제조방법Triphenylphosphine was reacted with carbon tetrachloride to produce triphenylchloromethylphosphonium chloride, and the compound was reacted with the compound of formula (2) to convert it into an acid chloride of formula (4) via a triphenylacyloxyphosphonium chloride derivative. A method for preparing a cefe derivative of Structural Formula (1), which is characterized by reacting with an amine compound of Structural Formula (5). 상기식에서 R은 수소 또는 보호기를, X1및 X2는 수소이거나, 다함께 알콕시이미노기를 의미하여, R1은 수소 또는 금속염을 R2는 (5-메틸-2H-테트라졸일)메틸기, (1,2,3-티아디아졸-5-일티오)메틸기, (아세틸옥시)메틸기, [(1-메틸-1H-테트라졸-5-일)티오]메틸기, [1-(2-디메틸아미노)에틸]-1H-테트라졸-5-일]티오]메틸기를 의미한다.Wherein R is hydrogen or a protecting group, X 1 and X 2 are hydrogen or alkoxyimino group together, R 1 is hydrogen or metal salt, R 2 is (5-methyl-2H-tetrazolyl) methyl group, (1 , 2,3-thiadiazole-5-ylthio) methyl group, (acetyloxy) methyl group, [(1-methyl-1H-tetrazol-5-yl) thio] methyl group, [1- (2-dimethylamino) Ethyl] -1H-tetrazol-5-yl] thio] methyl group. 제1항에 있어서, 상기 반응의 용매는 아세트니트릴, 디클로로메탄 또는 테트라히드로푸란 임을 특징으로 하는 세펨 유도체의 제조방법The method of claim 1, wherein the solvent of the reaction is acetonitrile, dichloromethane or tetrahydrofuran. 제1항에 있어서, 상기 구조식(5)의 화합물은 염기로서 트리에틸아민 또는 DBU를 포함하는 용매에 녹여져 반응됨을 특징으로 하는 세펨 유도체의 제조방법The method of claim 1, wherein the compound of formula (5) is dissolved in a solvent containing triethylamine or DBU as a base and reacted.
KR1019950055057A 1995-12-22 1995-12-22 Simple Method of Making Cemfe Derivatives KR970042559A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950055057A KR970042559A (en) 1995-12-22 1995-12-22 Simple Method of Making Cemfe Derivatives

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Application Number Priority Date Filing Date Title
KR1019950055057A KR970042559A (en) 1995-12-22 1995-12-22 Simple Method of Making Cemfe Derivatives

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KR970042559A true KR970042559A (en) 1997-07-24

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KR1019950055057A KR970042559A (en) 1995-12-22 1995-12-22 Simple Method of Making Cemfe Derivatives

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100432425B1 (en) * 2000-11-16 2004-05-22 씨제이 주식회사 Novel method for preparation of cephem derivatives or salts thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100432425B1 (en) * 2000-11-16 2004-05-22 씨제이 주식회사 Novel method for preparation of cephem derivatives or salts thereof

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