KR970042541A - Method for preparing alkyl phenylpropionate derivative-14C - Google Patents
Method for preparing alkyl phenylpropionate derivative-14C Download PDFInfo
- Publication number
- KR970042541A KR970042541A KR1019950048278A KR19950048278A KR970042541A KR 970042541 A KR970042541 A KR 970042541A KR 1019950048278 A KR1019950048278 A KR 1019950048278A KR 19950048278 A KR19950048278 A KR 19950048278A KR 970042541 A KR970042541 A KR 970042541A
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- KR
- South Korea
- Prior art keywords
- derivative
- alkyl
- phenylpropionate
- represented
- structural formula
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
본 발명은 알킬 페닐프로피오네이트 유도체-14C의 제조방법에 의한 것으로서, 더욱 상세하게는 다음 구조식(Ⅱ)로 표시되는 알킬페닐아세테이트 유도체와 매틸할라이드-14C를 디이소프로필아민과 n-부틸리튬의 염기 존재하에 테트라하이드로퓨란 용매에서 반응시켜 방사성 동위원소의 표지화합물로서 그리고 의약품 중간체로 유용한 다음 구조식(Ⅰ)로 표시되는 알킬 페닐프로피오레이트 유도체-14C를 고수율로 제조하는 방법에 관한 것이다.The present invention relates to a method for preparing alkyl phenyl propionate derivative-14C, and more specifically, to an alkylphenyl acetate derivative and methyl halide-14C represented by the following structural formula (II), diisopropylamine and n-butyllithium A method for producing an alkyl phenylpropiorate derivative-14C represented by the following structural formula (I), which is useful as a labeling compound for radioisotopes and as a pharmaceutical intermediate, by reacting in a tetrahydrofuran solvent in the presence of a base, in a high yield.
상기식에서*C는14C를 나타내고, R은이고,Where * C represents 14 C, and R is ego,
R1은 탄소원자수 1-3의 알킬기를 나타낸다.R 1 represents an alkyl group having 1-3 carbon atoms.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1019950048278A KR970042541A (en) | 1995-12-11 | 1995-12-11 | Method for preparing alkyl phenylpropionate derivative-14C |
Applications Claiming Priority (1)
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KR1019950048278A KR970042541A (en) | 1995-12-11 | 1995-12-11 | Method for preparing alkyl phenylpropionate derivative-14C |
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KR970042541A true KR970042541A (en) | 1997-07-24 |
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KR1019950048278A KR970042541A (en) | 1995-12-11 | 1995-12-11 | Method for preparing alkyl phenylpropionate derivative-14C |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5716840A (en) * | 1980-07-03 | 1982-01-28 | Sagami Chem Res Center | Phneylacetic acid derivative |
EP0088008A1 (en) * | 1982-02-26 | 1983-09-07 | Shionogi & Co., Ltd. | Improved process for the production of 2-(4-(2-thiazolyloxy)phenyl)propionic acid |
JPS5946242A (en) * | 1982-09-09 | 1984-03-15 | Agency Of Ind Science & Technol | Preparation of propionic acid having aromatic group at alpha-position and its ester |
JPH05306258A (en) * | 1992-03-03 | 1993-11-19 | Hitachi Chem Co Ltd | Optically active aromatic group-substituted alkanoic acid ester derivative, their intermediate and production |
-
1995
- 1995-12-11 KR KR1019950048278A patent/KR970042541A/en active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5716840A (en) * | 1980-07-03 | 1982-01-28 | Sagami Chem Res Center | Phneylacetic acid derivative |
EP0088008A1 (en) * | 1982-02-26 | 1983-09-07 | Shionogi & Co., Ltd. | Improved process for the production of 2-(4-(2-thiazolyloxy)phenyl)propionic acid |
JPS5946242A (en) * | 1982-09-09 | 1984-03-15 | Agency Of Ind Science & Technol | Preparation of propionic acid having aromatic group at alpha-position and its ester |
JPH05306258A (en) * | 1992-03-03 | 1993-11-19 | Hitachi Chem Co Ltd | Optically active aromatic group-substituted alkanoic acid ester derivative, their intermediate and production |
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