KR970042541A - Method for preparing alkyl phenylpropionate derivative-14C - Google Patents

Method for preparing alkyl phenylpropionate derivative-14C Download PDF

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Publication number
KR970042541A
KR970042541A KR1019950048278A KR19950048278A KR970042541A KR 970042541 A KR970042541 A KR 970042541A KR 1019950048278 A KR1019950048278 A KR 1019950048278A KR 19950048278 A KR19950048278 A KR 19950048278A KR 970042541 A KR970042541 A KR 970042541A
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KR
South Korea
Prior art keywords
derivative
alkyl
phenylpropionate
represented
structural formula
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KR1019950048278A
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Korean (ko)
Inventor
유광희
김영석
임종길
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김준웅
주식회사 선경인더스트리
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Priority to KR1019950048278A priority Critical patent/KR970042541A/en
Publication of KR970042541A publication Critical patent/KR970042541A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 알킬 페닐프로피오네이트 유도체-14C의 제조방법에 의한 것으로서, 더욱 상세하게는 다음 구조식(Ⅱ)로 표시되는 알킬페닐아세테이트 유도체와 매틸할라이드-14C를 디이소프로필아민과 n-부틸리튬의 염기 존재하에 테트라하이드로퓨란 용매에서 반응시켜 방사성 동위원소의 표지화합물로서 그리고 의약품 중간체로 유용한 다음 구조식(Ⅰ)로 표시되는 알킬 페닐프로피오레이트 유도체-14C를 고수율로 제조하는 방법에 관한 것이다.The present invention relates to a method for preparing alkyl phenyl propionate derivative-14C, and more specifically, to an alkylphenyl acetate derivative and methyl halide-14C represented by the following structural formula (II), diisopropylamine and n-butyllithium A method for producing an alkyl phenylpropiorate derivative-14C represented by the following structural formula (I), which is useful as a labeling compound for radioisotopes and as a pharmaceutical intermediate, by reacting in a tetrahydrofuran solvent in the presence of a base, in a high yield.

상기식에서*C는14C를 나타내고, R은이고,Where * C represents 14 C, and R is ego,

R1은 탄소원자수 1-3의 알킬기를 나타낸다.R 1 represents an alkyl group having 1-3 carbon atoms.

Description

알킬 페닐프로피오네트 유도체-14C의 제조방법Method for preparing alkyl phenylpropionate derivative-14C

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

알킬페닐아세테이트 유도체와 매틸할라이드-14C를 염기 존재하에서 반응시켜 다음 구조식(Ⅰ)로 표시되는 알킬 페닐프로피오레이트 유도체-14C를 제조하는 방법에 있어서, 상기 염기로는 n-부틸 리튬과 디이소프로필아민을 사용하는 것을 특징으로 하는 알킬 페닐프로피오네이트 유도체-14C의 제조방법A method of preparing an alkyl phenyl propiorate derivative-14C represented by the following structural formula (I) by reacting an alkylphenyl acetate derivative with methyl halide-14C in the presence of a base, wherein the base is n-butyl lithium and diisopropyl. Method for producing alkyl phenylpropionate derivative-14C characterized by using an amine 상기식에서*C는14C를 나타내고, R은이고,Where * C represents 14 C, and R is ego, R1은 탄소원자수 1-3의 알킬기를 나타낸다.R 1 represents an alkyl group having 1-3 carbon atoms. 제1항에 있어서, 상기 알킬 페닐아세테이트 유도체 1몰에 대하여 n-부틸 리튬 0.9-1.4몰과 디이소프로필아민 0.9-1.1몰 사용하는 것을 특징으로 하는 알킬 페닐프로피오네이트 유도체-14C의 제조방법The method of claim 1, wherein 0.9-1.4 mol of n-butyl lithium and 0.9-1.1 mol of diisopropylamine are used for 1 mol of the alkyl phenylacetate derivative.
KR1019950048278A 1995-12-11 1995-12-11 Method for preparing alkyl phenylpropionate derivative-14C KR970042541A (en)

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KR1019950048278A KR970042541A (en) 1995-12-11 1995-12-11 Method for preparing alkyl phenylpropionate derivative-14C

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KR1019950048278A KR970042541A (en) 1995-12-11 1995-12-11 Method for preparing alkyl phenylpropionate derivative-14C

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KR970042541A true KR970042541A (en) 1997-07-24

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5716840A (en) * 1980-07-03 1982-01-28 Sagami Chem Res Center Phneylacetic acid derivative
EP0088008A1 (en) * 1982-02-26 1983-09-07 Shionogi & Co., Ltd. Improved process for the production of 2-(4-(2-thiazolyloxy)phenyl)propionic acid
JPS5946242A (en) * 1982-09-09 1984-03-15 Agency Of Ind Science & Technol Preparation of propionic acid having aromatic group at alpha-position and its ester
JPH05306258A (en) * 1992-03-03 1993-11-19 Hitachi Chem Co Ltd Optically active aromatic group-substituted alkanoic acid ester derivative, their intermediate and production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5716840A (en) * 1980-07-03 1982-01-28 Sagami Chem Res Center Phneylacetic acid derivative
EP0088008A1 (en) * 1982-02-26 1983-09-07 Shionogi & Co., Ltd. Improved process for the production of 2-(4-(2-thiazolyloxy)phenyl)propionic acid
JPS5946242A (en) * 1982-09-09 1984-03-15 Agency Of Ind Science & Technol Preparation of propionic acid having aromatic group at alpha-position and its ester
JPH05306258A (en) * 1992-03-03 1993-11-19 Hitachi Chem Co Ltd Optically active aromatic group-substituted alkanoic acid ester derivative, their intermediate and production

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