KR970042513A - Histidine derivative, preparation method thereof and pharmaceutical composition containing same - Google Patents

Histidine derivative, preparation method thereof and pharmaceutical composition containing same Download PDF

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Publication number
KR970042513A
KR970042513A KR1019950072321A KR19950072321A KR970042513A KR 970042513 A KR970042513 A KR 970042513A KR 1019950072321 A KR1019950072321 A KR 1019950072321A KR 19950072321 A KR19950072321 A KR 19950072321A KR 970042513 A KR970042513 A KR 970042513A
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South Korea
Prior art keywords
alkyl
hydrogen
compound
pharmaceutical composition
formula
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Application number
KR1019950072321A
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Korean (ko)
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KR0178086B1 (en
Inventor
배훈
고동현
김동진
정성목
안양수
Original Assignee
손경식
제일제당 주식회사
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Priority to KR1019950072321A priority Critical patent/KR0178086B1/en
Publication of KR970042513A publication Critical patent/KR970042513A/en
Application granted granted Critical
Publication of KR0178086B1 publication Critical patent/KR0178086B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. 청구범위에 기재된 발명이 속한 기술분야 유기화합물 및 약학1.Organic compounds and pharmaceuticals in the technical field to which the invention described in the claims belong

2. 발명이 해결하려고 하는 기술적 과제 개선된 안지오텐신 Ⅱ길항제의 개발2. Technical problem to be solved by invention Development of improved angiotensin II antagonist

3. 발명의 해결방법의 요지 하기 일반식(Ⅰ)로 표시되는 화합물(여기서, R1은 C1-6알킬, C2-6알케닐 또는 C3-7사이클로알킬이고, R2는 -COOH, -SO2NHR4, 또는 C결합형 테트라졸이며, R3은 수소, 또는 C1-6알킬이고, R4는 R1으로 치환된 벤질이며, X는 수소, 산소, 또는 황이고, Y는 하이드록시, C1-6알콕시, C1-6카르복실, 또는 피리딘카르복실이다) :3. Summary of Solution of the Invention Compound represented by the following general formula (I), wherein R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 3-7 cycloalkyl, and R 2 is —COOH , -SO 2 NHR 4 , or C-bond tetrazole, R 3 is hydrogen, or C 1-6 alkyl, R 4 is benzyl substituted with R 1 , X is hydrogen, oxygen, or sulfur, Y is Hydroxy, C 1-6 alkoxy, C 1-6 carboxyl, or pyridinecarboxyl):

(Ⅰ) (Ⅰ)

4. 발명의 중요한 용도 중추신경계 질환 및 심장혈관계 질환의 치료제4. Significant Uses of the Invention Agents for Central Nervous System Disease and Cardiovascular Disease

Description

히스티딘 유도체, 이의 제조방법 및 이를 함유한 약제학적 조성물Histidine derivative, preparation method thereof and pharmaceutical composition containing same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염Compound of Formula (I) or a pharmaceutically acceptable salt thereof 상기식에서 R1은 C1-6알킬, C2-6알케닐 또는 C3-7사이클로알킬이고, R2는 -COOH, -SO2NHR4, 또는 C결합형 테트라졸이며, R3은 수소, 또는 C1-6알킬이고, R4는 R1으로 치환된 벤질이며, X는 수소, 산소, 또는 황이고, Y는 하이드록시, C1-6알콕시, C1-6카르복실, 또는 피리딘카르복실이다.Wherein R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 3-7 cycloalkyl, R 2 is —COOH, —SO 2 NHR 4, or C-bond tetrazole, R 3 is hydrogen, or C 1-6 alkyl, R 4 is Benzyl substituted with R 1, X is hydrogen, oxygen, or sulfur, and Y is hydroxy, C 1-6 alkoxy, C 1-6 carboxyl, or pyridinecarboxyl. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키고, 임의로 X 및 Y를 상호전환시키거나, 탈보호시키거나, 산 또는 염기와 반응시켜 염을 형성시켜 상기된 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염을 제조하는 방법The compound of formula (II) is reacted with a compound of formula (III) and optionally X and Y are interconverted, deprotected, or reacted with an acid or base to form a salt to form a salt of formula (I) To prepare a compound or a pharmaceutically acceptable salt thereof 상기식에서, R1은 C1-6알킬, C2-6알케닐 또는 C3-7사이클로알킬이고, R2는 -COOH, -SO2NHR4, 또는 C결합형 테트라졸이며, R3은 수소, 또는 C1-6알킬이고, R4는 R1으로 치환된 벤질이며, X는 수소, 산소, 또는 황이고, Y는 하이드록시, C1-6알콕시, C1-6카르복실, 또는 피리딘카르복실이다.Wherein R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 3-7 cycloalkyl, R 2 is —COOH, —SO 2 NHR 4, or C-bonded tetrazole, R 3 is hydrogen, or C 1-6 alkyl, R 4 Is benzyl substituted by R 1, X is hydrogen, oxygen, or sulfur and Y is hydroxy, C 1-6 alkoxy, C 1-6 carboxyl, or pyridinecarboxyl. 제1항에 따른 화합물과 약제학적으로 허용되는 담체가 혼합되어, 안지오텐신 Ⅱ의 작용에 의한 질병을 치료하는데 사용하는 약제학적 조성물A pharmaceutical composition for use in treating a disease caused by the action of angiotensin II by mixing the compound according to claim 1 with a pharmaceutically acceptable carrier.
KR1019950072321A 1995-12-21 1995-12-21 Histidine derivatives and process for the preparation thereof KR0178086B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950072321A KR0178086B1 (en) 1995-12-21 1995-12-21 Histidine derivatives and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950072321A KR0178086B1 (en) 1995-12-21 1995-12-21 Histidine derivatives and process for the preparation thereof

Publications (2)

Publication Number Publication Date
KR970042513A true KR970042513A (en) 1997-07-24
KR0178086B1 KR0178086B1 (en) 1999-03-20

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KR1019950072321A KR0178086B1 (en) 1995-12-21 1995-12-21 Histidine derivatives and process for the preparation thereof

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KR0178086B1 (en) 1999-03-20

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