KR970042522A - N-substituted hetero compound, preparation method thereof and pharmaceutical composition containing same - Google Patents

N-substituted hetero compound, preparation method thereof and pharmaceutical composition containing same Download PDF

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Publication number
KR970042522A
KR970042522A KR1019950072318A KR19950072318A KR970042522A KR 970042522 A KR970042522 A KR 970042522A KR 1019950072318 A KR1019950072318 A KR 1019950072318A KR 19950072318 A KR19950072318 A KR 19950072318A KR 970042522 A KR970042522 A KR 970042522A
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South Korea
Prior art keywords
substituted
unsubstituted
compound
formula
ethoxy
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KR1019950072318A
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Korean (ko)
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KR0181215B1 (en
Inventor
김동진
박성용
고동현
이건호
정성목
안양수
Original Assignee
손경식
제일제당 주식회사
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Priority to KR1019950072318A priority Critical patent/KR0181215B1/en
Publication of KR970042522A publication Critical patent/KR970042522A/en
Application granted granted Critical
Publication of KR0181215B1 publication Critical patent/KR0181215B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. 청구범위에 기재되어 있는 발명이 속하는 기술분야 유기화합물 및 약학1. Organic compounds and pharmaceuticals in the technical field to which the invention described in the claims belong

2. 그 발명이 해결하고자 하는 기술분야 개선된 안지오텐신 Ⅱ길항제의 개발2. Development of an angiotensin II antagonist improved in the technical field to be solved by the present invention

3. 그 기술적 과제의 해결방법의 요지 하기 일반식(Ⅰ)로 표시되는 화합물 (Ⅰ) (여기서, R1은 C1내지 C6알킬 또는 C1내지 C6알켄이고, R2는 하이드록시, 에톡시 또는 메톡시이며, R3은 C결합형 테트라졸, 카르복시 또는 디알킬아미노설페이트이고, X는 비치환되거나, 에톡시메텐, 메톡시메텐, 에톡시옥심 또는 메톡시옥심으로 치환된 메틸렌 ; 또는 비치환되거나, 하나이상의 메틸, 에틸 또는 벤질로 치환된 불포화 에텐 ; 또는3. Summary of Solution to the Technical Problem Compound (I) represented by the following general formula (I), wherein R 1 is C 1 to C 6 alkyl or C 1 to C 6 alkene, R 2 is hydroxy, Methylene substituted with ethoxy or methoxy, R 3 is C-bond tetrazole, carboxy or dialkylaminosulfate, X is unsubstituted or substituted with ethoxymethene, methoxymethene, ethoxy oxime or methoxy oxime; Or unsaturated ethene unsubstituted or substituted with one or more methyl, ethyl or benzyl; or

이다) : to be) :

4. 발명의 중요한 용도 중추신경계 질환 및 심장혈관게 질환의 치료제4. Significant Uses of the Invention Agents for Central Nervous System and Cardiovascular Diseases

Description

N-치환 헤테로 화합물, 이의 제조방법 및 이를 함유한 약제학적 조성물N-substituted hetero compound, preparation method thereof and pharmaceutical composition containing same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

하기 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염A compound of formula (I) or a pharmaceutically acceptable salt thereof 상기식에서,In the above formula, R1은 C1내지 C6알킬 또는 C1내지 C6알켄이고,R 1 is C 1 to C 6 alkyl or C 1 to C 6 alkene, R2는 하이드록시, 에톡시 또는 메톡시이며,R 2 is hydroxy, ethoxy or methoxy, R3은 C결합형 테트라졸, 카르복시 또는 디알킬아미노설페이트이고,R 3 is C-bond tetrazole, carboxy or dialkylaminosulfate, X는 비치환되거나, 에톡시메텐, 메톡시메텐, 에톡시옥심 또는 메톡시옥심으로 치환된 메틸렌; 또는 비치환되거나, 하나이상의 메틸, 에틸 또는 벤질로 치환된 불포화 에텐 ; 또는이다.X is methylene unsubstituted or substituted with ethoxymethene, methoxymethene, ethoxyoxime or methoxyoxime; Or unsaturated ethene unsubstituted or substituted with one or more methyl, ethyl or benzyl; or to be. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시켜 일반식(Ⅰ)의 화합물 또는 이의 염을 제조하는 방법A process for preparing a compound of formula (I) or a salt thereof by reacting a compound of formula (II) with a compound of formula (III) 상기식에서,In the above formula, R1은 C1내지 C6알킬 또는 C1내지 C6알켄이고,R 1 is C 1 to C 6 alkyl or C 1 to C 6 alkene, R2는 하이드록시, 에톡시 또는 메톡시이며,R 2 is hydroxy, ethoxy or methoxy, R3은 C결합형 테트라졸, 카르복시 또는 디알킬아미노설페이트이고,R 3 is C-bond tetrazole, carboxy or dialkylaminosulfate, X는 비치환되거나, 에톡시메텐, 메톡시메텐, 에톡시옥심 또는 메톡시옥심으로 치환된 메틸렌; 또는 비치환되거나, 하나이상의 메틸, 에틸 또는 벤질로 치환된 불포화 에텐 ; 또는이다.X is methylene unsubstituted or substituted with ethoxymethene, methoxymethene, ethoxyoxime or methoxyoxime; Or unsaturated ethene unsubstituted or substituted with one or more methyl, ethyl or benzyl; or to be. 제1항에 따른 화합물과 약제학적으로 허용되는 담체가 혼합되어, 안지오텐신 Ⅱ의 작용에 의한 질병을 치료하는데 사용하는 약제학적 조성물A pharmaceutical composition for use in treating a disease caused by the action of angiotensin II by mixing the compound according to claim 1 with a pharmaceutically acceptable carrier.
KR1019950072318A 1995-12-21 1995-12-21 N-substituted hetero compound, and its preparation process KR0181215B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950072318A KR0181215B1 (en) 1995-12-21 1995-12-21 N-substituted hetero compound, and its preparation process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950072318A KR0181215B1 (en) 1995-12-21 1995-12-21 N-substituted hetero compound, and its preparation process

Publications (2)

Publication Number Publication Date
KR970042522A true KR970042522A (en) 1997-07-24
KR0181215B1 KR0181215B1 (en) 1999-03-20

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