KR970010172B1 - (2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal - Google Patents

(2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal Download PDF

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Publication number
KR970010172B1
KR970010172B1 KR94001564A KR19940001564A KR970010172B1 KR 970010172 B1 KR970010172 B1 KR 970010172B1 KR 94001564 A KR94001564 A KR 94001564A KR 19940001564 A KR19940001564 A KR 19940001564A KR 970010172 B1 KR970010172 B1 KR 970010172B1
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KR
South Korea
Prior art keywords
hydroxymethyl
octahydroindol
alcohal
octahydroindole
synthesis
Prior art date
Application number
KR94001564A
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Korean (ko)
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KR950023641A (en
Inventor
Yong-Hae Kim
Doo-Han Park
Ill-Suk Byun
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Korea Advanced Inst Sci & Tech
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Publication date
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Priority to KR94001564A priority Critical patent/KR970010172B1/en
Publication of KR950023641A publication Critical patent/KR950023641A/en
Application granted granted Critical
Publication of KR970010172B1 publication Critical patent/KR970010172B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to (2S,3aS,7aS)-2-(hydroxymethyl)octahydroindol, process for preparing thereof and the synthetic method of optical active (S)-secondary alcohol using only a catalytic amount of reduce chiral compound as a auxiliary agent to reduce stereoselectively. (S)-indolin-2-carboxylic acid is converted into (S)-indolin-2-carboxylic acid ethyl ester using thionyl chloride and ethanol, which is reduced by white metal-platinum oxide to produce (2S,3aS,7aS)-octahydroindol-2-carboxylic ethyl ester, which is reduced by lithium aluminium hydride to form (2S,3aS,7aS)-2-(hydroxymethyl)octahydroindol.
KR94001564A 1994-01-28 1994-01-28 (2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal KR970010172B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR94001564A KR970010172B1 (en) 1994-01-28 1994-01-28 (2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR94001564A KR970010172B1 (en) 1994-01-28 1994-01-28 (2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal

Publications (2)

Publication Number Publication Date
KR950023641A KR950023641A (en) 1995-08-18
KR970010172B1 true KR970010172B1 (en) 1997-06-21

Family

ID=19376394

Family Applications (1)

Application Number Title Priority Date Filing Date
KR94001564A KR970010172B1 (en) 1994-01-28 1994-01-28 (2s, 3as, 7as)-2-(hydroxymethyl) octahydroindole, its process for the manufacture use for synthesis of(s) -secondary alcohal

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KR (1) KR970010172B1 (en)

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Publication number Publication date
KR950023641A (en) 1995-08-18

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