KR970009789A - Stable liquid formulation containing high concentration of acetaminophen and Socheong-ryongtang extract, and preparation method thereof - Google Patents

Stable liquid formulation containing high concentration of acetaminophen and Socheong-ryongtang extract, and preparation method thereof Download PDF

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Publication number
KR970009789A
KR970009789A KR1019950024813A KR19950024813A KR970009789A KR 970009789 A KR970009789 A KR 970009789A KR 1019950024813 A KR1019950024813 A KR 1019950024813A KR 19950024813 A KR19950024813 A KR 19950024813A KR 970009789 A KR970009789 A KR 970009789A
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South Korea
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acetaminophen
socheongryongtang
polyethylene glycol
preparation
component selected
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KR1019950024813A
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Korean (ko)
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KR100396115B1 (en
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최성규
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유충식
동아제약 주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 아세토아미노펜과 소청룡탕을 주제로 한 감기약에 있어서, 아세트아미노펜과 소청룡탕을 주제로 하고 여기에, 1) 폴락싸머 0.1∼5.0%(w/w) 및 싸이클로덱스트린 0.1∼5.0%(w/w)에서 선택된 1종 이상의 성분과; 2) 글리세린 0.2∼5.0%(w/w), 폴리에틸렌글리콜 400 0.1∼5.0%(w/w), 폴리에틸렌클리콜 4000 0.1∼5.0%(w/w) 및 프로필렌글리콜 0.2∼5.0%(w/w)에서 선택된 1종 이상의 성분; 및 3) 에탄올 0.2∼4.0%(v/v)을 가하고 용해하여 나머지는 물로 이루어진 것을 특징으로 하는 감기약 액제를 제공하는 것이며, 본 발명의 방법에 의하여 고온, 저온 및 동결과 해동에 안정한 액생제제가 가능하게 되었다.The present invention is a cold medicine based on acetoaminophen and socheongryongtang, comprising acetaminophen and socheongryongtang, wherein 1) poloxamer 0.1-5.0% (w / w) and cyclodextrin 0.1-5.0% (w / w). At least one component selected from; 2) Glycerin 0.2-5.0% (w / w), Polyethylene glycol 400 0.1-5.0% (w / w), Polyethylene glycol 4000 0.1-5.0% (w / w) and Propylene glycol 0.2-5.0% (w / w At least one component selected from; And 3) adding 0.2 to 4.0% (v / v) of ethanol and dissolving the remaining water to provide a cold medicine solution, wherein the aquatic preparation stable by high temperature, low temperature and freezing and thawing by the method of the present invention It became possible.

Description

고농도의 아세트아미노펜 및 소청룡탕 엑기스를 함유하는 안정한 액상제제 및 그 제조방법.A stable liquid formulation containing a high concentration of acetaminophen and Socheong-ryongtang extract, and a preparation method thereof.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

아세트아미노펜과 소청룡탕을 주제로 하고 여기에, 1) 폴록싸머 0.1∼5.0%(w/w) 및 싸이클로덱스트린 0.1∼5.0%(w/w)에서 선택된 1종 이상과; 2) 글리세린 0.2∼5.0%(w/w), 폴리에틸렌글리콜 400 0.1∼5.0%(w/w), 폴리에틸렌글리콜 4000 0.1∼5.0%(w/w) 및 프로필렌글리콜 0.2∼5.0%(w/w)에서 선택된 1종 이상의 성분; 및 3) 에탄올 0.2∼4.0%(v/v)을 가하고 물에 용해하여, 나머지는 물로 이루어진 것을 특징으로 하여 제조된 아세트아미노펜과 소청룡탕을 주제로 하는 고온, 저온 및 동결과 해동에 안정한 액상제제.Subject to acetaminophen and socheongryongtang, wherein: 1) at least one selected from poloxamer 0.1-5.0% (w / w) and cyclodextrin 0.1-5.0% (w / w); 2) Glycerin 0.2-5.0% (w / w), polyethylene glycol 400 0.1-5.0% (w / w), polyethylene glycol 4000 0.1-5.0% (w / w) and propylene glycol 0.2-5.0% (w / w) At least one component selected from; And 3) 0.2 to 4.0% (v / v) of ethanol, dissolved in water, and the remainder is composed of water. 제1항에서, 약제학적으로 허용되는 통상의 감미제, 산미제, 방부제 및 기타 통상의 보조제를 첨가하여 제조된 아세트아미노펜과 소청룡탕을 주제로 하는 고온, 저온 및 동결과 해동에 안정한 액상제제.2. A liquid formulation stable at high temperatures, low temperatures and freezing and thawing based on acetaminophen and Socheongryongtang prepared by the addition of pharmaceutically acceptable conventional sweeteners, acidulants, preservatives and other conventional auxiliaries. 아세트아미노펜과 소청룡탕을 주제로 하고 여기에, 1) 폴록싸머 0.1∼5.0%(w/w) 및 싸이클로덱스트린 0.1∼5.0%(w/w)에서 선택된 1종 이상의 성분과; 2) 글리세린 0.2∼5.0%(w/w), 폴리에틸렌글리콜 400 0.1∼5.0%(w/w), 폴리에틸렌글리콜 4000 0.1∼5.0%(w/w) 및 프로필렌글리콜 0.2∼5.0%(w/w)에서 선택된 1종 이상의 성분; 및 3) 에탄올 0.2∼4.0%(v/v)을 가하고 물에 용해하는 것을 특징으로 하는 아세트아미노펜과 소청룡탕을 주제로 하는 고온, 저온 및 동결과 해동에 안정안 액상 제제의 제조방법.Acetoaminophen and socheongryongtang, wherein: 1) at least one component selected from 0.1 to 5.0% (w / w) of poloxamer and 0.1 to 5.0% (w / w) of cyclodextrin; 2) Glycerin 0.2-5.0% (w / w), polyethylene glycol 400 0.1-5.0% (w / w), polyethylene glycol 4000 0.1-5.0% (w / w) and propylene glycol 0.2-5.0% (w / w) At least one component selected from; And 3) 0.2 to 4.0% (v / v) of ethanol and dissolving it in water, wherein the liquid preparation is stable at high temperatures, low temperatures and freezing and thawing based on acetaminophen and Socheongryongtang. 제3항에 있어서, 약제학적으로 허용되는 통상의 감미제, 산미제, 방부제 및 기타 통상의 보조제를 첨가하여 제조된 아세트아미노펜과 소청룡탕을 주제로 하는 고온, 저온 및 동결과 해동에 안정한 액상 제제를 제조하는 방법.The preparation of liquid formulations stable to high temperature, low temperature and freezing and thawing based on acetaminophen and Socheongryongtang prepared by adding conventional pharmaceutically acceptable sweeteners, acidulants, preservatives and other conventional auxiliaries. How to. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950024813A 1995-08-11 1995-08-11 Stabilized liquid phase preparation containing high concentration of acetaminophen and socheongnyongtang(minor decoction of blue dragon) and method for manufacturing the same KR100396115B1 (en)

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US183183A (en) * 1876-10-10 Improvement in cultivators
KR920003960A (en) * 1990-08-31 1992-03-27 정형식 Method of manufacturing stabilized drinks
KR930012003A (en) * 1991-12-23 1993-07-20 한기명 Cheon Wang Bo Shim and its manufacturing method
KR100215168B1 (en) * 1997-04-16 1999-08-16 우재영 Liquid formulation of herbal composition having no precipitation and improved taste

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