KR970005184B1 - Soft capsule containing calcium - Google Patents
Soft capsule containing calcium Download PDFInfo
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- KR970005184B1 KR970005184B1 KR1019930026264A KR930026264A KR970005184B1 KR 970005184 B1 KR970005184 B1 KR 970005184B1 KR 1019930026264 A KR1019930026264 A KR 1019930026264A KR 930026264 A KR930026264 A KR 930026264A KR 970005184 B1 KR970005184 B1 KR 970005184B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
본 발명은 예컨대 우골분 칼슘을 첨가한 연질캡슐에 관한 것으로, 더욱 상세하게는 연질캡슐에 우골분의 칼슘을 첨가하고 이산화티타늄(Titania, Tio2) 및 향을 섞음으로 이미 및 이취가 없어지는 연질캡슐에 관한 것이다.The present invention relates to soft capsules, for example, added bone calcium powder, more specifically, soft capsules that are already and odor-free by adding calcium powder of beef bone powder to the soft capsule and mixing titanium dioxide (Titania, Tio2) and flavor. It is about.
인간의 체력과 체형을 보존하고 유지하기 위하여 많은 무기질 중 칼슘이 필요하며, 특히 운동을 많이하는 사람에게는 더욱 많은양의 칼슘이 필요하게 된다. 상기 칼슘음 인체 구성 무기질중 약1/2을 차지하게 되는 바, 이는 성장과 체력유지, 자주적인 근육운동의 수축(contraction)과 이완(relaxation), 신경세포의 구성, 근육운동에 의한 산성생성물질은 중화(neutralization)하여 세포막을 투과시켜 체외로 배설시키는 역할(땀등으로)등을 하게된다.Calcium is needed in many minerals to preserve and maintain human fitness and body shape, especially for those who exercise a lot more calcium. The calcium sound accounts for about one-half of the human body minerals, which are growth and stamina, constriction and relaxation of voluntary muscle movement, the composition of nerve cells, and acid production by muscle movement. Is neutralized (neutralization) to permeate the cell membrane to excrete outside the body (to sweat, etc.).
따라서, 상기와 같이 중요한 칼슘은 땀으로 100mg/he이상(체외로 배출되는 전칼슘의 30%)배출되어 칼슘부족현상이 일어나며, 외부로 부터의 공급이 부족할 때에는 골성분에서 칼슘을 탈출시켜 보충하게 되므로 골다공증(Osteoporosis)현상이 일어나고, 또 칼슘에 결합되어 있던 인(phosphrous)의 유리로 체질은 산독증(acidosis)을 일으켜 뼈 구조물인 인산칼슘은 과린산칼슘의 형태로 용해도가 증가하여 공다공증상태기 가속회되게 된다. 상기와 같은 문제뿐만 아니라 칼슘부족으로 인한 어린이의 발육부진, 성인 및 어린이의 치아와 골격의 약화들 많은 문제점이 대두되고 있어 칼슘의 섭취에 대한 많은 연구가 되어지고 있다.Therefore, important calcium is discharged over 100mg / he (30% of all calcium released into the body) by sweat, causing calcium deficiency, and when the supply from the outside is insufficient, it is necessary to escape and supplement calcium from bone components. Osteoporosis occurs, and the phosphorus, which is bound to calcium, causes constitution of acidosis. It will be accelerated. In addition to the above problems, as a result of the lack of calcium, the development of children, weakening of the teeth and skeleton of adults and children has been a lot of problems have been a lot of research on the intake of calcium.
한편, 상기와 같이 인체내에서 존재하는 무기질중 가장 많이 소요되고 중요한 칼슘은 식품에서 많은 량을 섭취하여야 하나, 식품중에 공존하는 여러종류의 무기질 때문에 실제 흡수하기 어려운 무기질중의 하나다. 도한, 현대인들의 육식과 가공식품에 의한 인의 많은 섭취 및 신경의 다양화에 의한 칼슘의 많은 소모 때문에 칼슘의 부족현상이 가속화하고 있으므로 칼슘의 흡수는 더욱 절실하게 되는 것이다.On the other hand, the most required and important calcium among the minerals present in the human body as described above should be consumed in large amounts in food, one of the minerals that are difficult to actually absorb because of the various types of minerals coexist in food. In addition, the absorption of calcium is more urgent because the lack of calcium is accelerating due to the large intake of phosphorus by the meat and processed food of modern people and the large consumption of calcium due to the diversification of nerves.
본 발명은 상기와 같은 문제점을 해결하기 위하여 발명한 것으로서 연질캡슐의 제조시 우골분의 칼슘을 첨가하여 칼슘연질캡슐을 제조함으로, 상기 캡슐을 간단히 인체내에서 필요한 소화 흡수도를 높일 수 있는 칼슘을 첨가한 연질캡슐을 제공하고자 함에 그 목적이 있다.The present invention has been invented to solve the above problems, by preparing calcium soft capsules by adding calcium of the right bone flour during the manufacture of soft capsules, the capsules are simply calcium to increase the digestive absorption required in the human body The purpose is to provide added soft capsules.
본 발명의 연질캡슐은, 연질캡슐을 제조할 때 젤라틴에 가소제를 혼합하여 용액으로 만들어 우골분의 칼슘을 첨가하고, 이산화티타늄 및 향을 섞어 성형, 충전 및 건조한 이미 및 이취가 없는 칼슘연질캡슐이다.The soft capsule of the present invention is a calcium soft capsule which is molded and filled, dried and odorless calcium soft capsule by mixing a plasticizer with gelatin to prepare a soft capsule, adding calcium of cow bone powder, and mixing titanium dioxide and fragrance when preparing the soft capsule. .
일반적으로 약품이나 식품을 보관이 용이하고 섭취를 편리하게 하기 위하여 연질캡슐을 제조하여 약품이나 식품에 삽입하거나 켑슐제조시 약품이나 식품을 첨가하는 방법이 많이 사용되고 있다. 상기 연질캡슐은 젤라틴을 녹여서 물과 가소제를 혼합하여 아교형태로 만들고 캡슐형태의 성형물애 주입하여 제조하는 것으로, 상기 벨라틴이 인체내에 들어갔을 때 습도와 온도에 의하여 인체내에서 용해되어 소화흡수 되도록 되어있다. 캡슐에는 하드켑슐과 연질켑슐이 있으며, 캡슐내의 물질이 분말인 항생제 및 감기약등은 하드켑슐을 제조하여 기계로 분말을 삽입하여 제조하며, 우루서Vt.E등의 내뇬물이 유체인 것은 연질캡슐을 제조하여 액체 또는 분발을 유액에 혼합하여 현탁액을 만들어 연질캡슐에 삽입하거나 연질캡슐제조시에 약품이나 식품의 성분을 같이 혼합하여 제조한다.In general, in order to easily store drugs and foods and to facilitate ingestion, soft capsules are manufactured and inserted into drugs or foods, or methods of adding drugs or foods when preparing capsules are used. The soft capsule is prepared by dissolving gelatin and mixing water and plasticizer to make a glue form and injecting a molded product into a capsule form. When the velatine enters the human body, it is dissolved in the human body by humidity and temperature to be digested and absorbed. It is. There are hard capsules and soft capsules, and antibiotics and cold medicines, which are powders, are manufactured by inserting powders into machines by making hard capsules, and soft capsules when the internal substances such as Vt.E are fluids. To prepare a suspension by mixing the liquid or powder into the emulsion to insert into a soft capsule or to prepare a soft capsule when mixing the ingredients of the drug or food.
본 발명의 연질캡슐은 연질캡슐의 재료인 젤라틴 및 글리세린에 우골분의 칼슘을 첨가한 칼슘연질캡슐로서, 얄질의 우골분에 산화, 변빌을 방지하기 위하여 이산화티타늄을 혼합하여 변질이 없을 뿐 아니라 냄새를 제거하기 위하여 바닐라향을 약간 혼합한, 이미, 이취가 없는 칼슘 연질캡슐이다. 본 발명의 캡슐에 첨가하는 우골분은 체내에서 뼈조직 이의 혈청에 존재하는 활성형태의 단백질 킬레이트(chelate)화된 칼슘으로서 이온상태로 물분자를 동반하고 있기 때문에 칼슘이온으로 생체기능작용에 임할 수 있다.The soft capsule of the present invention is a calcium soft capsule in which calcium of the right bone powder is added to gelatin and glycerin, which are the ingredients of the soft capsule, and is mixed with titanium dioxide in order to prevent oxidation and constipation in the yalk bone, and there is no deterioration and smell It is already a odorless calcium soft capsule, with a slight mixture of vanilla flavor to remove. The right bone flour added to the capsule of the present invention is a protein chelated calcium of the active form present in the serum of bone tissue thereof in the body, and is accompanied by a water molecule in an ionic state, so that it can play a biological function with calcium ions. .
인체에 필요한 칼슘을 섭취하는 일반적인 방법으로는 칼슘식품을 먹는 것이 있다. 그러나 칼슘식품을 섭취한다고해서 칼슘식품이 인체내에서 우리에게 필요한 칼슘으로 흡수되는 것은 아니다. 칼슘을 소화시킬수 없는 사람이 있고 또한 칼슘식품을 먹지못하는 사람도 있다. 상기와 같은 문제점을 해결하기 위하여 많은 칼슘제제들이 시중에 나와있지만, 상기 칼슘제제는 분말이나 정제로 되어 있는 분말제제인 경우에는 섭취할 때 어려움이 있을 뿐 아니라 좋지않은 맛과 향기를 느끼게 된다. 또 조개류나 뼈(동물뼈)를 분쇄하거나 태워서 얻어지는 인산칼슘제 칼슘은 물에 불용성이며, 또한 식품가운데 함유한 인의 장해요인 때문에 체내흡수가 어려우며, 보관이 용이하지 않으며 변질이 쉽게 된다는 문제점이 있으며, 정제인 경우에는 인체내에서 용해되기 어렵고 또한 소화 흡수도가 떨어진다는 문제점도 있다. 본 발명에서 사용되는 우골분을 분말로 만들었을시 섭취하는데 거부감이 있을 뿐 아니라 변질이 쉽게 된다. 우골분을 본 발명과 같이 연질캡슐로 제조하면 변질이 쉽게 되지 않고 섭취, 소화 및 흡수도가 좋은 양질의 칼슘제제로 제조하게 되어 연질캡슐에서 필요한 칼슘을 편리한 방법으로 흡수할 수 있는 칼슘제제외 캡슐화인 것이다. 본 발명의 연질캡슐은 아래와 같이 제조한다. 젤라틴을 온도를 70-80℃정도로 하고 용해시키기 위하여 가소제로서 의약용 글리세린을 첨가하여 용해시킨다. 상기 아교와 같은 혼합액에 칼슘분인 식용소성우골분을 첨가하고 칼슘성분의 변질을 막기위하여 이산화티타늄을 첨가하고 고유의 냄새를 제거하고 향기를 주기위하여 바닐라향을 첨가한다. 상기 혼합물은 캡슐형태의 성형물에 충전한다. 상기 충전물을 습도40%, 온도24℃정도에서 건조시킨다. 상기 성형된 캡슐릉 습도60%, 온도40℃이하에서 보관한다.A common way to get the calcium you need is to eat calcium. However, consuming calcium foods does not mean that calcium foods are absorbed into our body by the calcium we need. Some people can't digest calcium, and some people can't eat calcium. In order to solve the above problems, many calcium preparations are on the market, but the calcium preparations are powdered or tableted powder formulations, which are not only difficult to ingest, but also have a bad taste and aroma. Calcium phosphate calcium obtained by crushing or burning shellfish or bones (animal bone) is insoluble in water, and because of the obstacles of phosphorus in food, it is difficult to absorb the body, is not easy to store, and it is easy to deteriorate. In the case that is difficult to dissolve in the human body also has a problem that the digestive absorption is poor. When the right bone powder used in the present invention is made into a powder, there is not only a feeling of refusal to ingest, but also easy deterioration. When the cow bone powder is produced in a soft capsule as in the present invention, it is not easily deteriorated, and is manufactured as a high-quality calcium preparation with good intake, digestion, and absorption. . The soft capsule of the present invention is prepared as follows. In order to dissolve gelatin at a temperature of about 70-80 ° C., it is dissolved by adding glycerine as a plasticizer. To the mixture, such as glue, edible calcined bone flour is added, and titanium dioxide is added to prevent the alteration of calcium components, vanilla flavor is added to remove the inherent odor and give a scent. The mixture is filled into a molding in capsule form. The filling is dried at a humidity of 40% and a temperature of about 24 ° C. The molded capsule tomb humidity 60%, the temperature is stored below 40 ℃.
실시예Example
젤라틴 63.6%과 글리세린 26.80%를 첨가하여 75℃온도에서 혼합한다. 상기 혼합액에 식용소성우골분을 9.00% 첨가하고 이산화티타늄 0.50% 및 마닐라향 0.10%를 첨가하여 혼합한다. 상기 혼합액을 성형물에 충전한다. 상기 성형물을 습도40%, 온도 24℃에서 건조시킨다. 상기 연질캡슐을 실온에서 보관한다.Add 63.6% gelatin and 26.80% glycerin and mix at 75 ℃. 9.00% of edible beef bone flour is added to the mixture, and 0.50% of titanium dioxide and 0.10% of manila flavor are added and mixed. The mixture is filled into moldings. The molded product is dried at a humidity of 40% and a temperature of 24 ° C. Store the soft capsule at room temperature.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019930026264A KR970005184B1 (en) | 1993-12-02 | 1993-12-02 | Soft capsule containing calcium |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1019930026264A KR970005184B1 (en) | 1993-12-02 | 1993-12-02 | Soft capsule containing calcium |
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| KR950016761A KR950016761A (en) | 1995-07-20 |
| KR970005184B1 true KR970005184B1 (en) | 1997-04-14 |
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| KR1019930026264A KR970005184B1 (en) | 1993-12-02 | 1993-12-02 | Soft capsule containing calcium |
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