KR970001357A - Benzimidazole derivatives containing conjugated pyridine - Google Patents

Benzimidazole derivatives containing conjugated pyridine Download PDF

Info

Publication number
KR970001357A
KR970001357A KR1019950016621A KR19950016621A KR970001357A KR 970001357 A KR970001357 A KR 970001357A KR 1019950016621 A KR1019950016621 A KR 1019950016621A KR 19950016621 A KR19950016621 A KR 19950016621A KR 970001357 A KR970001357 A KR 970001357A
Authority
KR
South Korea
Prior art keywords
group
atom
hydrogen atom
structural formula
following structural
Prior art date
Application number
KR1019950016621A
Other languages
Korean (ko)
Other versions
KR0154281B1 (en
Inventor
염을균
최중권
조성윤
강승규
김성수
박경호
황기준
천혜경
김효정
양성일
Original Assignee
강박광
재단법인 한국화학연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 강박광, 재단법인 한국화학연구소 filed Critical 강박광
Priority to KR1019950016621A priority Critical patent/KR0154281B1/en
Priority to PCT/KR1996/000091 priority patent/WO1997000875A1/en
Publication of KR970001357A publication Critical patent/KR970001357A/en
Application granted granted Critical
Publication of KR0154281B1 publication Critical patent/KR0154281B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Abstract

본 발명은 포유동물의 위상분비 억제능력을 보유하고 있어 항궤양제의 유효성분으로서 매우 유용한 다음 구조식(Ⅰ)로 표시되는 접합고리 피리딘을 함유한 벤즈이미다졸 유도체에 관한 것이다.The present invention relates to a benzimidazole derivative containing a conjugated ring pyridine represented by the following structural formula (I), which has a mammalian phase secretion inhibitory ability and is very useful as an active ingredient of an antiulcer agent.

상기 식에서, R은 수소원자, 할로겐원자, C1∼C3의 알콕시, C1∼C3의 할로알콕시 또는 C1∼C3의 할로알킬기 이고; X는이고; R1, R2 ,R3, R4, R5및 R6은 서로 같거나 다른 것으로서 수소원자, 할로겐원자 또는 C1∼C3의 알킬기를 나타내되 다만, 모두 수소원자인 경우에는 제외한다.Wherein R is a hydrogen atom, a halogen atom, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy or C 1 -C 3 haloalkyl group; X is ego; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same as or different from each other and represent a hydrogen atom, a halogen atom or an alkyl group of C 1 to C 3 , except when all are hydrogen atoms.

Description

접합고리 피리딘을 함유한 벤즈이미다졸 유도체Benzimidazole derivatives containing conjugated pyridine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

다음 구조식(Ⅰ)로 표시되는 접합고리 피리딘을 함유한 벤즈이미다졸 유도체.Benzimidazole derivatives containing the conjugated ring pyridine represented by the following structural formula (I). 상기 식에서, R은 수소원자, 할로겐원자, C1∼C3의 알콕시, C1∼C3의 할로알콕시 또는 C1∼C3의 할로알킬기 이고; X는이고; R1, R2, R3, R4, R5및 R6은 서로 같거나 다른 것으로서 수소원자, 할로겐원자 또는 C1∼C3의 알킬기를 나타내되 다만, 모두 수소원자인 경우는 제외한다.Wherein R is a hydrogen atom, a halogen atom, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy or C 1 -C 3 haloalkyl group; X is ego; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , which are the same as or different from each other, represent a hydrogen atom, a halogen atom or an alkyl group of C 1 to C 3 , except that all are hydrogen atoms. 제1항에 있어서, 상기 R이 수소원자, 염소원자, 브롬원자, 플루오르원자, 메톡시기, 에톡시기, 프로필옥시기, 트리플루오로메틸기 또는 2,2-디플루오로에톡시기인 것을 특징으로 하는 접합고리 피리딘을 함유한 벤즈이미다졸 유도체.The method of claim 1, wherein R is a hydrogen atom, chlorine atom, bromine atom, fluorine atom, methoxy group, ethoxy group, propyloxy group, trifluoromethyl group or 2,2-difluoroethoxy group, characterized in that Benzimidazole derivatives containing conjugated pyridine. 제1항에 있어서, 상기 R1, R2, R3, R4, R5및 R6가 각각 같거나 다른 것으로서 수소원자, 메틸기, 에틸기 또는 프로필기(다만, 모두 수소원자인 경우에는 제외) 인것을 특징으로 하는 접합고리 피리딘을 함유한 벤즈이미다졸 유도체.The method according to claim 1, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different, respectively, hydrogen atom, methyl group, ethyl group or propyl group (except when all are hydrogen atoms) Benzimidazole derivatives containing conjugated pyridine, characterized in that the. 다음 구조식(Ⅰ)로 표시되는 벤즈아미다졸 유도체 및 이들의 약학적으로 허용가능한 염을 유효성분으로 함유하고 있는 것을 특징으로 하는 위궤양 치료제 조성물.Benzamidazole derivatives represented by the following structural formula (I) and pharmaceutically acceptable salts thereof as an active ingredient, gastric ulcer therapeutic composition characterized in that it contains. 상기 식에서, R과 X는 상기 특허청구위 범의 제1항에서 정의한 바와 같다.Wherein R and X are as defined in claim 1 of the claims. 제4항에 있어서, 상기 약제학적으로 허용가능한 염은 산부가염 또는 나트륨염인 것을 특징으로 하는 위궤양 치료제 조성물.The gastric ulcer therapeutic composition according to claim 4, wherein the pharmaceutically acceptable salt is acid addition salt or sodium salt. 제4항에 있어서, 상기 R1, R2, R3, R4, R5및 R6가 각각 같거나 다른 것으로서 수소원자, 메틸기, 에틸기 또는 프로필기(다만, 모두 수소원자인 경우에는 제외)인 것을 특징으로 하는 의궤양 치료제 조성물.The method according to claim 4, wherein R 1 , R 2 , R 3 , R 4 , R 5, and R 6 are the same or different, and each hydrogen atom, methyl group, ethyl group or propyl group (except when all are hydrogen atoms) An ulcer treatment composition, characterized in that. 다음 구조식(Ⅰ)로 표시되는 화합물 제조에 유용한 다음 구조식(Ⅴ)로 표시되는 화합물.A compound represented by the following structural formula (V) useful for the preparation of a compound represented by the following structural formula (I). 상기 식에서, R과 X는 상기 특허청구의 범위 제1항에서 정의한 바와 같다.Wherein R and X are as defined in claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950016621A 1995-06-21 1995-06-21 Benzimidazole derivatives containing fused pyridines KR0154281B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019950016621A KR0154281B1 (en) 1995-06-21 1995-06-21 Benzimidazole derivatives containing fused pyridines
PCT/KR1996/000091 WO1997000875A1 (en) 1995-06-21 1996-06-12 Benzimidazole derivatives containing fused pyridine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950016621A KR0154281B1 (en) 1995-06-21 1995-06-21 Benzimidazole derivatives containing fused pyridines

Publications (2)

Publication Number Publication Date
KR970001357A true KR970001357A (en) 1997-01-24
KR0154281B1 KR0154281B1 (en) 1998-11-16

Family

ID=19417710

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950016621A KR0154281B1 (en) 1995-06-21 1995-06-21 Benzimidazole derivatives containing fused pyridines

Country Status (1)

Country Link
KR (1) KR0154281B1 (en)

Also Published As

Publication number Publication date
KR0154281B1 (en) 1998-11-16

Similar Documents

Publication Publication Date Title
LU92113I2 (en) Perampanel and its pharmaceutically acceptable derivatives (FYCOMPA)
FR2800375B1 (en) TRICYCLIC DERIVATIVES OF PYRAZOLECARBOXYLIC ACID, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR870004030A (en) Condensed Imidazo Pyridine Derivatives
KR940019701A (en) N-heteroaryl-N'-phenylurea derivatives, preparation method and use thereof
KR940014384A (en) Phenoxy- and phenoxyalkyl-piperidine as antiviral agents
EP1304329A3 (en) Pyridonecarboxylic acid derivatives and their use as antibacterial agents
KR900018074A (en) N-heteroaryl-4-quinolinamine, preparation method thereof and use thereof as medicament
KR960022486A (en) New Thiazolidin-4-one Derivatives
ATE402151T1 (en) 2-(ARYLPHENYL)AMINO-IMIDAZOLINE DERIVATIVES
NZ221699A (en) Pyridazinone derivatives; pharmaceutical compositions and intermediates
NO890440L (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ISOKINOLINE DERIVATIVES.
NO177995C (en) Analogous process for the preparation of therapeutically active 1,3-dioxane derivatives
KR880002828A (en) Dihydropyridine derivatives and pharmaceutical compositions thereof
KR970001357A (en) Benzimidazole derivatives containing conjugated pyridine
KR930021629A (en) Piperazine Derivatives
EP0860169A3 (en) Compositions for oral administration containing pyridazinone compounds
KR890008121A (en) Rhodanine Derivatives and Pharmaceutical Compositions
DK1370539T3 (en) HIV inhibiting N-aminoimidazole derivatives
KR970001360A (en) Thienopyrimidone Derivatives Containing Pyridine
KR960034199A (en) Benzimidazole derivatives containing pyrazole
KR930006017A (en) New quinoline-3-carboxylic acid derivatives and preparation method thereof
KR910016759A (en) Benzoxazine derivatives and preparation method thereof
KR930700501A (en) New Sulfonyl Compounds
KR960004363A (en) Pyrimidine Acyclonucleoside Derivatives
KR960010641A (en) Benzimidazole derivatives with cyclized imidazole

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20010605

Year of fee payment: 4

LAPS Lapse due to unpaid annual fee