KR960705771A - 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine) - Google Patents

구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine) Download PDF

Info

Publication number
KR960705771A
KR960705771A KR1019960702743A KR19960702743A KR960705771A KR 960705771 A KR960705771 A KR 960705771A KR 1019960702743 A KR1019960702743 A KR 1019960702743A KR 19960702743 A KR19960702743 A KR 19960702743A KR 960705771 A KR960705771 A KR 960705771A
Authority
KR
South Korea
Prior art keywords
amphoteric material
amphoteric
carbon atoms
guanidine
nitrogen
Prior art date
Application number
KR1019960702743A
Other languages
English (en)
Korean (ko)
Inventor
디.헤쓰 티모티
솔로딘 이고르
Original Assignee
벤자민 에프 맥그로우
메가바이오스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 벤자민 에프 맥그로우, 메가바이오스 코포레이션 filed Critical 벤자민 에프 맥그로우
Publication of KR960705771A publication Critical patent/KR960705771A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1019960702743A 1993-11-24 1994-11-17 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine) KR960705771A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15772793A 1993-11-24 1993-11-24
US08/157,727 1993-11-24
US24800594A 1994-05-24 1994-05-24
US08/248,005 1994-05-24
PCT/US1994/013428 WO1995014381A1 (fr) 1993-11-24 1994-11-17 Derives amphiphiles de guanidine

Publications (1)

Publication Number Publication Date
KR960705771A true KR960705771A (ko) 1996-11-08

Family

ID=26854424

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960702743A KR960705771A (ko) 1993-11-24 1994-11-17 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine)

Country Status (8)

Country Link
EP (1) EP0730405A4 (fr)
JP (1) JPH09505808A (fr)
KR (1) KR960705771A (fr)
AU (1) AU691226B2 (fr)
CA (1) CA2176715A1 (fr)
NO (1) NO962074L (fr)
NZ (1) NZ276975A (fr)
WO (1) WO1995014381A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650096A (en) * 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5840710A (en) * 1994-12-09 1998-11-24 Genzyme Corporation Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules
US5948767A (en) * 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes
US5767099A (en) * 1994-12-09 1998-06-16 Genzyme Corporation Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
US5719131A (en) * 1994-12-09 1998-02-17 Genzyme Corporation Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
US6383814B1 (en) 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5910487A (en) * 1994-12-09 1999-06-08 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
US6331524B1 (en) 1994-12-09 2001-12-18 Genzyme Corporation Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
US5747471A (en) * 1994-12-09 1998-05-05 Genzyme Corporation Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules
US5830878A (en) 1995-06-07 1998-11-03 Megabios Corporation Cationic lipid: DNA complexes for gene targeting
WO1997019675A2 (fr) 1995-11-30 1997-06-05 Vical Incorporated Lipides cationiques complexes
SE9504347D0 (sv) * 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
EP0779361A3 (fr) 1995-12-15 1999-11-10 F. Hoffmann-La Roche Ag Forme tronquée de la protéine inhibitrice kappa B, production récombinante et utilisation
CZ295225B6 (cs) * 1996-03-01 2005-06-15 Centre National De La Recherche Scientifique Amidiniový derivát a farmaceutický prostředek tento derivát obsahující
US5935936A (en) * 1996-06-03 1999-08-10 Genzyme Corporation Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
US5861397A (en) * 1996-10-03 1999-01-19 Vical Incorporated Piperazine based cytofectins
CA2217550A1 (fr) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Lipides cationiques pour therapie genique
US5925628A (en) * 1997-03-31 1999-07-20 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5958894A (en) * 1997-04-04 1999-09-28 Megabios Corporation Amphiphilic biguanide derivatives
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
US5912239A (en) * 1997-04-04 1999-06-15 Genzyme Corporation Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
US5948925A (en) * 1997-05-06 1999-09-07 Genzyme Corporation Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
US5952516A (en) * 1997-05-08 1999-09-14 Genzyme Corporation Cationic amphiphiles containing multiplesteroid lipophilic groups
US5942634A (en) * 1997-05-09 1999-08-24 Genzyme Corporation Cationic amphiphiles for cell transfections
FR2763943B1 (fr) * 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
JP2001523480A (ja) 1997-11-20 2001-11-27 バイカル インコーポレイテッド サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
US9301980B2 (en) 2013-07-16 2016-04-05 The Board Of Trustees Of The Leland Stanford Junio Enhancement of osteogenic potential of bone grafts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules

Also Published As

Publication number Publication date
NZ276975A (en) 1998-04-27
JPH09505808A (ja) 1997-06-10
EP0730405A1 (fr) 1996-09-11
WO1995014381A1 (fr) 1995-06-01
CA2176715A1 (fr) 1995-06-01
AU1184295A (en) 1995-06-13
NO962074D0 (no) 1996-05-21
EP0730405A4 (fr) 1997-02-19
NO962074L (no) 1996-07-11
AU691226B2 (en) 1998-05-14

Similar Documents

Publication Publication Date Title
KR960705771A (ko) 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine)
KR960705798A (ko) 피페라진의 양쪽친화성 유도체(amphiphilic derivatives of piperazine)
SE8404225D0 (sv) Novel esters, their preparation and use
RU94045952A (ru) Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена
KR860004123A (ko) 방사경화성 셀룰로오스 코팅조성물
ES2120523T3 (es) Organopolisiloxano-polieteres y su empleo como agentes de reticulacion estables a la hidrolisis en sistemas acuosos.
AU7851591A (en) Quaternerised esters obtained from alkanol amines with fatty acids and their use as reviving agent
KR830003505A (ko) 피로포스파토 티타네이트 부가물
ATE172451T1 (de) Vitamin d analoge
AU7576896A (en) Lipopolyamines as transfection agents and their pharmaceutical applications
NZ290757A (en) Delivery of nucleic acid into a cell
FR2812551B1 (fr) Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
NO962073L (no) Amfifiliske imidazoliniumderivater
KR880001325A (ko) 포스포에스테르를 기초로한 새로운 장력활성 조성물, 그들의 제조방법과 그들의 활성물질 제제에의 응용
DE69022176T2 (de) Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.
FI912198A (fi) Laitteisto useiden tuotteiden asettamiseksi pidikenauhojen pidikkeisiin
DE60014133D1 (de) Neutrale-kationische lipide zur verabreichung von nukleinesäuren und arzneimitteln
CA2299429A1 (fr) Nouvelles lipopolyamines, leurs methodes de preparation, et utilisations connexes
EP0728763A4 (fr) Analogue de ganglioside gm3 dote d'un residu d'acide sialique fluore en position 9, et intermediaire necessaire
ES484324A1 (es) Procedimiento para la obtencion de (n,n'-hidroxialquil)-ami-dinas de acido azo-di-isobutirico
GB2324528A (en) Cytostatic hydroxamic acid derivatives
ES2149882T3 (es) Tensioactivos.
ES2161484T3 (es) Procedimiento para la obtencion de polietilenglicolesteres de acidos grasos.
DK1047658T3 (da) Fremgangsmåde til fremstilling af alkoxylerede dimerfedtsyrer
KR890701603A (ko) 페로센 유도체, 그것을 함유한 계면 활성제 및 유기박막의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application