KR960037695A - Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus - Google Patents

Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus Download PDF

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KR960037695A
KR960037695A KR1019960036690A KR19960036690A KR960037695A KR 960037695 A KR960037695 A KR 960037695A KR 1019960036690 A KR1019960036690 A KR 1019960036690A KR 19960036690 A KR19960036690 A KR 19960036690A KR 960037695 A KR960037695 A KR 960037695A
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South Korea
Prior art keywords
ssa
52kda
60kda
lupus erythematosus
systemic lupus
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KR1019960036690A
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Korean (ko)
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김호연
박종상
변재철
박성환
정민영
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김호연
박종상
변재철
박성환
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Priority to KR1019960036690A priority Critical patent/KR960037695A/en
Publication of KR960037695A publication Critical patent/KR960037695A/en

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Abstract

본 발명은 사람의 전신홍반성 루푸스병(systemic lupus erythematosus)의 진단에 사용될 수 있는 60kDa 및 52kDa Ro/SSA 항원의 항원결정기(epitope)를 포함하는 펩티드에 관한 것이다. 좀 더 구체적으로, 본 발명은 사람의 60kDa Ro/SSA 항원의 항원결정기를 포함하는 7가지 펩티드군 및 52kDa Ro/SSA 항원의 항원결정기를 포함하는 4가지의 펩티드군과 그들의 전신홍반성 루푸스병에 대한 진단키트로서의 용도에 관한 것이다.The present invention relates to a peptide comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus in humans. More specifically, the present invention relates to seven peptide groups comprising epitopes of human 60kDa Ro / SSA antigens and four peptide groups comprising epitopes of 52kDa Ro / SSA antigens and their systemic lupus erythematosus. It relates to the use as a diagnostic kit.

전술한 본 발명의 펩티드군은 전신홍반성 루푸스병 환자로부터 채형한 혈청을 사용하는 ELISA 분석을 통하여 각각 60kDa 및 52kDa Ro/SSA 항원의 항원결정기로 실제 기능하며, 전신홍반성 루푸스병의 진단용으로 이용될 수 있음이 밝혀졌다. 따라서, 60kDa 및 52kDa Ro/SSA 항원의 전체 단백질이 없어도 본 발명의 펩티드만으로도 전신홍반성 루푸스병의 진단이 가능하므로, 본 발명의 펩티드를 이용하여 더 용이하고 비용도 절감되는 전신홍반성 루푸스병의 진단키트를 제조할 수 있다. 또한, 본 발명의 펩티드를 사용하여 항-60kDa 및 52kDa Ro/SSA 체원를 생산할 수 있다.The above-described peptide group of the present invention actually functions as an epitope of 60kDa and 52kDa Ro / SSA antigens through ELISA analysis using serum collected from patients with systemic lupus erythematosus, and can be used for diagnosis of systemic lupus erythematosus. It turns out that. Therefore, even without the entire protein of 60kDa and 52kDa Ro / SSA antigen, it is possible to diagnose systemic lupus erythematosus using only the peptide of the present invention. Can be prepared. In addition, the peptides of the invention can be used to produce anti-60kDa and 52kDa Ro / SSA sources.

Description

전신홍반성 루푸스병의 진단에 사용될 수 있는 60kDa 및 52kDa Ro/SSA 항원의 항원 결정기를 포함하는Containing antigenic determinants of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제2도는 60kDa Ro/SSA 항원의 아미노산 서열과 항원결정기가 될 수 있는 7가지 아미노산 서열을 나타낸다.Figure 2 shows the amino acid sequence of the 60 kDa Ro / SSA antigen and the seven amino acid sequences that can be epitopes.

제18도는 52kDa Ro/SSA 항원의 아미노산 서열과 항원결정기가 될 수 있는 4가지 아미노산 서열을 나타낸다.Figure 18 shows the amino acid sequence of the 52 kDa Ro / SSA antigen and the four amino acid sequences that can be epitopes.

Claims (3)

사람의 60kDa Ro/SSA 항원의 항원결정기에 해당하는 하기와 같은 아미노산 서열로 구성된 그룹으로부터 선택되는 어느 한가지 이상을 포함하는 펩티드 및 그의 기능적 등가물 : TYYIKEQKLGLW ; WCSQCSDISTK ; WTFIQFKKDLKE ; WAVTKYKQRNG ; KYLEAVEKVKRW ; GHGLRGKLKWRP ; 및, KALDAAFYKTW(상기에서, 아미노산 서열은 IUPAC 명명법에 따라 기재하였다).Peptides comprising any one or more selected from the group consisting of the following amino acid sequences corresponding to epitopes of the human 60 kDa Ro / SSA antigen and functional equivalents thereof: TYYIKEQKLGLW; WCSQCSDISTK; WTFIQFKKDLKE; WAVTKYKQRNG; KYLEAVEKVKRW; GHGLRGKLKWRP; And KALDAAFYKTW (wherein the amino acid sequence is described according to the IUPAC nomenclature). 사람의 52kDa Ro/SSA 항원의 항원결정기에 해당하는 하기와 같은 아미노산 서열로 구성된 그룹으로부터 선택되는 어느 한가지 이상을 포함하는 펩티드 및 그의 기능적 등가물 : KNLRPNRQLANW ; NNLKEISQEAREGTQGEW ; QSRKHRDHAW ; 및, VCRDSVRRKGHW(상기에서, 아미노산 서열은 IUPAC 명명법에 따라 기재하였다).Peptides comprising any one or more selected from the group consisting of the following amino acid sequences corresponding to epitopes of human 52 kDa Ro / SSA antigen and functional equivalents thereof: KNLRPNRQLANW; NNLKEISQEAREGTQGEW; QSRKHRDHAW; And VCRDSVRRKGHW (above, amino acid sequence is described according to IUPAC nomenclature). 제1항 또는 제2항의 펩티드를 사용하는 전신홍반성 루푸스병 (systemic lupus erythematosus)의 진단키트.A diagnostic kit for systemic lupus erythematosus using the peptide of claim 1 or 2. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019960036690A 1996-08-30 1996-08-30 Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus KR960037695A (en)

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KR1019960036690A KR960037695A (en) 1996-08-30 1996-08-30 Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus

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KR1019960036690A KR960037695A (en) 1996-08-30 1996-08-30 Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019216634A1 (en) * 2018-05-09 2019-11-14 아주대학교산학협력단 Diagnostic method for systemic lupus erythematosus using smyd3 autoantibody

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019216634A1 (en) * 2018-05-09 2019-11-14 아주대학교산학협력단 Diagnostic method for systemic lupus erythematosus using smyd3 autoantibody
KR20190128923A (en) * 2018-05-09 2019-11-19 아주대학교산학협력단 Diagnosis of Systemic Lupus Erythematosus Using SMYD3 Autoantibodies

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