KR960037695A - Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus - Google Patents
Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus Download PDFInfo
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- KR960037695A KR960037695A KR1019960036690A KR19960036690A KR960037695A KR 960037695 A KR960037695 A KR 960037695A KR 1019960036690 A KR1019960036690 A KR 1019960036690A KR 19960036690 A KR19960036690 A KR 19960036690A KR 960037695 A KR960037695 A KR 960037695A
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Abstract
본 발명은 사람의 전신홍반성 루푸스병(systemic lupus erythematosus)의 진단에 사용될 수 있는 60kDa 및 52kDa Ro/SSA 항원의 항원결정기(epitope)를 포함하는 펩티드에 관한 것이다. 좀 더 구체적으로, 본 발명은 사람의 60kDa Ro/SSA 항원의 항원결정기를 포함하는 7가지 펩티드군 및 52kDa Ro/SSA 항원의 항원결정기를 포함하는 4가지의 펩티드군과 그들의 전신홍반성 루푸스병에 대한 진단키트로서의 용도에 관한 것이다.The present invention relates to a peptide comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus in humans. More specifically, the present invention relates to seven peptide groups comprising epitopes of human 60kDa Ro / SSA antigens and four peptide groups comprising epitopes of 52kDa Ro / SSA antigens and their systemic lupus erythematosus. It relates to the use as a diagnostic kit.
전술한 본 발명의 펩티드군은 전신홍반성 루푸스병 환자로부터 채형한 혈청을 사용하는 ELISA 분석을 통하여 각각 60kDa 및 52kDa Ro/SSA 항원의 항원결정기로 실제 기능하며, 전신홍반성 루푸스병의 진단용으로 이용될 수 있음이 밝혀졌다. 따라서, 60kDa 및 52kDa Ro/SSA 항원의 전체 단백질이 없어도 본 발명의 펩티드만으로도 전신홍반성 루푸스병의 진단이 가능하므로, 본 발명의 펩티드를 이용하여 더 용이하고 비용도 절감되는 전신홍반성 루푸스병의 진단키트를 제조할 수 있다. 또한, 본 발명의 펩티드를 사용하여 항-60kDa 및 52kDa Ro/SSA 체원를 생산할 수 있다.The above-described peptide group of the present invention actually functions as an epitope of 60kDa and 52kDa Ro / SSA antigens through ELISA analysis using serum collected from patients with systemic lupus erythematosus, and can be used for diagnosis of systemic lupus erythematosus. It turns out that. Therefore, even without the entire protein of 60kDa and 52kDa Ro / SSA antigen, it is possible to diagnose systemic lupus erythematosus using only the peptide of the present invention. Can be prepared. In addition, the peptides of the invention can be used to produce anti-60kDa and 52kDa Ro / SSA sources.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제2도는 60kDa Ro/SSA 항원의 아미노산 서열과 항원결정기가 될 수 있는 7가지 아미노산 서열을 나타낸다.Figure 2 shows the amino acid sequence of the 60 kDa Ro / SSA antigen and the seven amino acid sequences that can be epitopes.
제18도는 52kDa Ro/SSA 항원의 아미노산 서열과 항원결정기가 될 수 있는 4가지 아미노산 서열을 나타낸다.Figure 18 shows the amino acid sequence of the 52 kDa Ro / SSA antigen and the four amino acid sequences that can be epitopes.
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Application Number | Priority Date | Filing Date | Title |
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KR1019960036690A KR960037695A (en) | 1996-08-30 | 1996-08-30 | Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus |
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KR1019960036690A KR960037695A (en) | 1996-08-30 | 1996-08-30 | Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus |
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KR1019960036690A KR960037695A (en) | 1996-08-30 | 1996-08-30 | Peptides comprising epitopes of 60kDa and 52kDa Ro / SSA antigens that can be used for the diagnosis of systemic lupus erythematosus |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019216634A1 (en) * | 2018-05-09 | 2019-11-14 | 아주대학교산학협력단 | Diagnostic method for systemic lupus erythematosus using smyd3 autoantibody |
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1996
- 1996-08-30 KR KR1019960036690A patent/KR960037695A/en active IP Right Grant
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019216634A1 (en) * | 2018-05-09 | 2019-11-14 | 아주대학교산학협력단 | Diagnostic method for systemic lupus erythematosus using smyd3 autoantibody |
KR20190128923A (en) * | 2018-05-09 | 2019-11-19 | 아주대학교산학협력단 | Diagnosis of Systemic Lupus Erythematosus Using SMYD3 Autoantibodies |
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