JO1671B1 - Methods for diagnosis of tuberculosis - Google Patents
Methods for diagnosis of tuberculosisInfo
- Publication number
- JO1671B1 JO1671B1 JO19911671A JOP19911671A JO1671B1 JO 1671 B1 JO1671 B1 JO 1671B1 JO 19911671 A JO19911671 A JO 19911671A JO P19911671 A JOP19911671 A JO P19911671A JO 1671 B1 JO1671 B1 JO 1671B1
- Authority
- JO
- Jordan
- Prior art keywords
- tuberculosis
- immuno
- human
- kda protein
- protein antigen
- Prior art date
Links
- 201000008827 tuberculosis Diseases 0.000 title abstract 5
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 101710159910 Movement protein Proteins 0.000 abstract 3
- 102100024147 Protein phosphatase 1 regulatory subunit 14A Human genes 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000002965 ELISA Methods 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000013399 early diagnosis Methods 0.000 abstract 1
- 230000000984 immunochemical effect Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000002297 mitogenic effect Effects 0.000 abstract 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Disclosed are the immunochemical properties of a 17 kDa protein antigen fractionated, purified and sequenced for amino acids from Mycobacterium tuberculosis (South Indian isolate, SII 1) which causes human tuberculosis worldwide among 16 million patients. The 17 kDa protein antigen which has an N-terminus of A T T L P V Q R (aa 1-8) has atleast three specific antibody binding epitopes located on linear peptides of sequences, R A T Y D K R Y E V R (aa 91-101) and S E F A Y G S F V R (aa 68-77) which were useful in a micro ELISA for the early diagnosis of human tuberculosis by the detection of specific antibodies. The 17 kDa protein antigen which was mitogenic for human tuberculous peripheral blood lymphocytes was found to carry three predicted T-cell epitopes on linear peptides of sequences, S E F A Y G S F V R (aa 68-77) and A E L P G V D P D C D V C I T R (aa 107-122). The 17 kDa antigen of M. tuberculosis (SII 1) which thus had both B and T cell reactive properties was found to contain 131 amino acids and potentially applicable in the immuno diagnosis, immuno therapy and immuno prophylaxis of human tuberculosis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9001105A SE9001105D0 (en) | 1990-03-27 | 1990-03-27 | NEW METHODS FOR DIAGNOSIS OR TUBERCULOSIS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO1671B1 true JO1671B1 (en) | 1992-08-09 |
Family
ID=20379003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO19911671A JO1671B1 (en) | 1990-03-27 | 1991-03-21 | Methods for diagnosis of tuberculosis |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0479971A1 (en) |
| CN (1) | CN1060310A (en) |
| AU (1) | AU7564491A (en) |
| BR (1) | BR9105237A (en) |
| IL (1) | IL97572A0 (en) |
| JO (1) | JO1671B1 (en) |
| PT (1) | PT97150A (en) |
| SE (1) | SE9001105D0 (en) |
| WO (1) | WO1991014448A1 (en) |
| ZA (1) | ZA911855B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6752993B1 (en) | 1993-11-23 | 2004-06-22 | The Regents Of The University Of California | Abundant extracellular product vaccines and methods for their production and use |
| WO1995014713A2 (en) | 1993-11-23 | 1995-06-01 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
| US7300660B2 (en) | 1993-11-23 | 2007-11-27 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
| US6592877B1 (en) | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6338852B1 (en) | 1995-09-01 | 2002-01-15 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6013660A (en) * | 1996-10-02 | 2000-01-11 | The Regents Of The University Of California | Externally targeted prophylactic and chemotherapeutic method and agents |
| US6465633B1 (en) | 1998-12-24 | 2002-10-15 | Corixa Corporation | Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis |
| CN103063836B (en) * | 2011-10-18 | 2016-03-30 | 复旦大学附属华山医院 | Detect the reagent of mycobacterial infections, method and kit |
| CN111518165B (en) * | 2020-05-08 | 2021-10-01 | 宁夏大学 | Polypeptide specifically binding to mycobacterium tuberculosis, coding gene and application thereof |
| CN112125954B (en) * | 2020-09-28 | 2023-02-28 | 宁夏医科大学总医院 | Heptapeptide specifically combined with BCG (bacillus calmette guerin), coding gene, preparation method and application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0345299A1 (en) * | 1987-02-02 | 1989-12-13 | Whitehead Institute For Biomedical Research | Mycobacterium tuberculosis genes encoding protein antigens |
| US4952395A (en) * | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
-
1990
- 1990-03-27 SE SE9001105A patent/SE9001105D0/en unknown
-
1991
- 1991-03-13 ZA ZA911855A patent/ZA911855B/en unknown
- 1991-03-15 IL IL97572A patent/IL97572A0/en unknown
- 1991-03-21 JO JO19911671A patent/JO1671B1/en active
- 1991-03-22 WO PCT/SE1991/000225 patent/WO1991014448A1/en not_active Application Discontinuation
- 1991-03-22 EP EP91906940A patent/EP0479971A1/en not_active Withdrawn
- 1991-03-22 AU AU75644/91A patent/AU7564491A/en not_active Abandoned
- 1991-03-22 BR BR919105237A patent/BR9105237A/en unknown
- 1991-03-26 PT PT97150A patent/PT97150A/en not_active Application Discontinuation
- 1991-03-27 CN CN91101235A patent/CN1060310A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA911855B (en) | 1991-12-24 |
| CN1060310A (en) | 1992-04-15 |
| PT97150A (en) | 1991-12-31 |
| BR9105237A (en) | 1992-07-21 |
| AU7564491A (en) | 1991-10-21 |
| IL97572A0 (en) | 1992-06-21 |
| EP0479971A1 (en) | 1992-04-15 |
| SE9001105D0 (en) | 1990-03-27 |
| WO1991014448A1 (en) | 1991-10-03 |
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