KR960031465A - Novel 4-substituted thiazolo [5,4-b] pyridine derivatives and preparation methods thereof - Google Patents

Novel 4-substituted thiazolo [5,4-b] pyridine derivatives and preparation methods thereof Download PDF

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Publication number
KR960031465A
KR960031465A KR1019950002632A KR19950002632A KR960031465A KR 960031465 A KR960031465 A KR 960031465A KR 1019950002632 A KR1019950002632 A KR 1019950002632A KR 19950002632 A KR19950002632 A KR 19950002632A KR 960031465 A KR960031465 A KR 960031465A
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South Korea
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group
substituted
lower alkyl
alkyl group
atom
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KR1019950002632A
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KR0144697B1 (en
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박영준
서귀현
김영훈
강대필
김영희
윤희선
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김종인
영진약품공업 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

본 발명은 소화성 궤양유발의 원인들 중 가장 주된 원인인 과도한 위산분비를 억제하기 위하여 위벽 세포내에서 일어나는 위산분비 메카니즘의 마지막 단계에 작용하는 효소인(H+/K+)-ATPase(양자펌프)를 억제함으로써 궤양치료의 효과를 가지는 약물 및 그의 약학적으로 사용가능한 염과 이의 제조방법에 관한 것이다.The present invention is an enzyme (H + / K + ) -ATPase (quantum pump) that acts at the last stage of gastric acid secretion mechanism that occurs in the cells of the stomach wall to suppress excessive gastric acid secretion, which is the main cause of peptic ulcer induction It relates to a drug having the effect of treating ulcers by inhibiting the pharmaceutically acceptable salts thereof and a method for preparing the same.

본 발명의 신규한 4-치환 티아졸로[5,4-b]피리딘 유도체들과 그의 약학적으로 사용가능한 염은 다음의 구조식(I)로 대표된다.The novel 4-substituted thiazolo [5,4-b] pyridine derivatives of the present invention and their pharmaceutically usable salts are represented by the following structural formula (I).

상기 일반식에서 R1은 C1∼C6의 저급 알킬기, 치환되거나 비치환된 벤질이고; R2는 수소원자, 히드록시기, C1∼C6의 저급 알킬기, C3∼C6의 시클로알킬기, C1∼C6의 저급알콕시기, C3∼C6의 시클로알콕시기 또는 저급알킬아민기이고; Q는 NH, O,S 등의 원자를 나타내며; 이때에 R3는 수소, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 아민기, 또는 치환된 아민기이며, 특히, 바람직한 약리작용을 갖는 물질로는 2-위치의 아민기이다.The general formula R 1 is a lower alkyl group of C 1 ~C 6, substituted or unsubstituted benzyl; R2 is a hydrogen atom, a hydroxyl group, a C 1 to C 6 lower alkyl group, a C 3 to C 6 cycloalkyl group, a C 1 to C 6 lower alkoxy group, a C 3 to C 6 cycloalkoxy group or a lower alkylamine group ; Q represents an atom such as NH, O, S or the like; At this time, R 3 is hydrogen, a halogen atom, a lower alkyl group, a lower alkoxy group, an amine group, or a substituted amine group, and in particular, a substance having preferred pharmacological action is an amine group in 2-position.

Description

신규한 4-치환티아졸로[5,4-b]피리딘 유도체 및 이의 제조방법.Novel 4-substituted thiazolo [5,4-b] pyridine derivatives and methods for their preparation.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

다음의 구조식(I)로 표기되는 신규한 4-치환티아졸로[5,4-b]피리딘 유도체와 그의 약학적으로 사용가능한 염.Novel 4-substituted thiazolo [5,4-b] pyridine derivatives represented by the following structural formula (I) and their pharmaceutically usable salts. 상기 일반식에서 R1은 C1∼C6의 저급 알킬기, 치환되거나 비치환된 벤질이고; R2는 수소원자, 히드록시기, C1∼C6의 저급 알킬기, C3∼C6의 시클로알킬기, C1∼C6의저급 알콕시기, C3∼C6의 시클로알콕시기 또는 저급 알킬아민기이고; Q는 NH, O, S등의 원자를 나타내며; 이때에 R3는 수소, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 아민기, 또는 치환된 아민기이다.The general formula R 1 is a lower alkyl group of C 1 ~C 6, substituted or unsubstituted benzyl; R 2 is a hydrogen atom, a hydroxyl group, a C 1 to C 6 lower alkyl group, a C 3 to C 6 cycloalkyl group, a C 1 to C 6 lower alkoxy group, a C 3 to C 6 cycloalkoxy group or a lower alkylamine group ego; Q represents an atom such as NH, O, S or the like; R 3 at this time is hydrogen, a halogen atom, a lower alkyl group, a lower alkoxy group, an amine group, or a substituted amine group. 다음의 일반식(Ⅱ)로부터 치환반응에 의한 일반식(I)의 제조하는 방법.A method for producing general formula (I) by substitution reaction from the following general formula (II). 상기 식에서, R1, R2는 특허청구의 범위 1항에서 서술한 바와 같고, X는 클로린, 브로민등의 할로겐원자나 술포네이트등의 반응성기를 나타낸다.In the above formula, R 1 and R 2 are as described in claim 1, and X represents a halogen atom such as chlorine, bromine, or a reactive group such as sulfonate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임※ Note: The disclosure is based on the initial application.
KR1019950002632A 1995-02-14 1995-02-14 Novel 4-substituted thiazo(5-4-6)pyridine derivatives and their proess preparing them KR0144697B1 (en)

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KR1019950002632A KR0144697B1 (en) 1995-02-14 1995-02-14 Novel 4-substituted thiazo(5-4-6)pyridine derivatives and their proess preparing them

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KR960031465A true KR960031465A (en) 1996-09-17
KR0144697B1 KR0144697B1 (en) 1998-07-15

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