KR960000866A - Method for preparing pyridine derivative - Google Patents
Method for preparing pyridine derivative Download PDFInfo
- Publication number
- KR960000866A KR960000866A KR1019940014840A KR19940014840A KR960000866A KR 960000866 A KR960000866 A KR 960000866A KR 1019940014840 A KR1019940014840 A KR 1019940014840A KR 19940014840 A KR19940014840 A KR 19940014840A KR 960000866 A KR960000866 A KR 960000866A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- iii
- preparing
- chloroacetonitrile
- Prior art date
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- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 위산분비 억제 특성을 갖는 벤즈이미다졸 유도체의 제조에 사용되는 중간체인 아래 구조식(Ⅰ)의 피리딘 유도체를 제조하는 방법에 관한 것으로, 구조식(Ⅱ)의 2-메틸-3-(2,2,2-트리플루오로에톡시)-1,3-부타디엔과 구조식(Ⅲ)의 2-클로로아세토니트릴을 반응시켜 연속공정으로 간단하게 목적화합물을 제조하는 방법을 제공하는 바, 구조식(Ⅲ)의 화합물을 스포릴클로리드로 처리하여 아래 구조식(Ⅳ)의 이미노클로리드 중간체를 형성시킨 뒤 이를 구조식(Ⅱ)의 화합물과 반응시키고 CS2를 이용하여 탈수소화시킴으로써 연속공정으로 구조식(Ⅰ)의 화합물을 제조하거나, 구조식(Ⅱ)의 화합물과 구조식(Ⅲ)의 화합물을 루이스산 촉매 존재 하에 한 단계로 반응시킴으로서 구조식(Ⅰ)의 화합물을 용이하게 제조하며, 기존의 방법에 있어서와 같은 인체에 유해한 중간체가 전혀 형성되지 않는다.The present invention relates to a method for preparing a pyridine derivative of formula (I), which is an intermediate used in the preparation of benzimidazole derivatives having gastric acid secretion inhibitory properties, 2-methyl-3- (2, Provided is a method for preparing a desired compound in a continuous process by reacting 2,2-trifluoroethoxy) -1,3-butadiene with 2-chloroacetonitrile of formula (III), formula (III) Was treated with sporyl chloride to form the iminochloride intermediate of formula (IV), which was then reacted with a compound of formula (II) and dehydrogenated using CS 2 to form a continuous process (I). Or a compound of formula (II) by reacting a compound of formula (II) with a compound of formula (III) in a single step in the presence of a Lewis acid catalyst. Harmful intermediates are not formed at all.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940014840A KR0131051B1 (en) | 1994-06-27 | 1994-06-27 | Process for preparing pyridine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940014840A KR0131051B1 (en) | 1994-06-27 | 1994-06-27 | Process for preparing pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960000866A true KR960000866A (en) | 1996-01-25 |
KR0131051B1 KR0131051B1 (en) | 1998-04-17 |
Family
ID=19386399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940014840A KR0131051B1 (en) | 1994-06-27 | 1994-06-27 | Process for preparing pyridine derivatives |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR0131051B1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000063317A (en) * | 2000-06-26 | 2000-11-06 | 김영렬 | Composition for straight cooling |
KR100395221B1 (en) * | 2001-03-21 | 2003-08-19 | 송현갑 | Refrigerant mixture |
KR20030083248A (en) * | 2002-04-19 | 2003-10-30 | 퍼스텍주식회사 | Binary azeotropic-like refrigerant compositions |
-
1994
- 1994-06-27 KR KR1019940014840A patent/KR0131051B1/en not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000063317A (en) * | 2000-06-26 | 2000-11-06 | 김영렬 | Composition for straight cooling |
KR100395221B1 (en) * | 2001-03-21 | 2003-08-19 | 송현갑 | Refrigerant mixture |
KR20030083248A (en) * | 2002-04-19 | 2003-10-30 | 퍼스텍주식회사 | Binary azeotropic-like refrigerant compositions |
Also Published As
Publication number | Publication date |
---|---|
KR0131051B1 (en) | 1998-04-17 |
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