KR960000866A - Method for preparing pyridine derivative - Google Patents

Method for preparing pyridine derivative Download PDF

Info

Publication number
KR960000866A
KR960000866A KR1019940014840A KR19940014840A KR960000866A KR 960000866 A KR960000866 A KR 960000866A KR 1019940014840 A KR1019940014840 A KR 1019940014840A KR 19940014840 A KR19940014840 A KR 19940014840A KR 960000866 A KR960000866 A KR 960000866A
Authority
KR
South Korea
Prior art keywords
formula
compound
iii
preparing
chloroacetonitrile
Prior art date
Application number
KR1019940014840A
Other languages
Korean (ko)
Other versions
KR0131051B1 (en
Inventor
백성인
김기석
Original Assignee
하기주
주식회사 코오롱
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하기주, 주식회사 코오롱 filed Critical 하기주
Priority to KR1019940014840A priority Critical patent/KR0131051B1/en
Publication of KR960000866A publication Critical patent/KR960000866A/en
Application granted granted Critical
Publication of KR0131051B1 publication Critical patent/KR0131051B1/en

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 위산분비 억제 특성을 갖는 벤즈이미다졸 유도체의 제조에 사용되는 중간체인 아래 구조식(Ⅰ)의 피리딘 유도체를 제조하는 방법에 관한 것으로, 구조식(Ⅱ)의 2-메틸-3-(2,2,2-트리플루오로에톡시)-1,3-부타디엔과 구조식(Ⅲ)의 2-클로로아세토니트릴을 반응시켜 연속공정으로 간단하게 목적화합물을 제조하는 방법을 제공하는 바, 구조식(Ⅲ)의 화합물을 스포릴클로리드로 처리하여 아래 구조식(Ⅳ)의 이미노클로리드 중간체를 형성시킨 뒤 이를 구조식(Ⅱ)의 화합물과 반응시키고 CS2를 이용하여 탈수소화시킴으로써 연속공정으로 구조식(Ⅰ)의 화합물을 제조하거나, 구조식(Ⅱ)의 화합물과 구조식(Ⅲ)의 화합물을 루이스산 촉매 존재 하에 한 단계로 반응시킴으로서 구조식(Ⅰ)의 화합물을 용이하게 제조하며, 기존의 방법에 있어서와 같은 인체에 유해한 중간체가 전혀 형성되지 않는다.The present invention relates to a method for preparing a pyridine derivative of formula (I), which is an intermediate used in the preparation of benzimidazole derivatives having gastric acid secretion inhibitory properties, 2-methyl-3- (2, Provided is a method for preparing a desired compound in a continuous process by reacting 2,2-trifluoroethoxy) -1,3-butadiene with 2-chloroacetonitrile of formula (III), formula (III) Was treated with sporyl chloride to form the iminochloride intermediate of formula (IV), which was then reacted with a compound of formula (II) and dehydrogenated using CS 2 to form a continuous process (I). Or a compound of formula (II) by reacting a compound of formula (II) with a compound of formula (III) in a single step in the presence of a Lewis acid catalyst. Harmful intermediates are not formed at all.

Description

피리딘 유도체의 제조방법Method for preparing pyridine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

구조식(Ⅱ)의 2-메틸-3-(2,2,2,-트리플루오로에톡시)-1,3-부타디엔과 구조식(Ⅲ)의 2-클로로아세토니트릴을 반응시켜, 연속공정으로 구조식(Ⅰ)의 화합물을 제조하는 방법.2-methyl-3- (2,2,2, -trifluoroethoxy) -1,3-butadiene of formula (II) and 2-chloroacetonitrile of formula (III) are reacted to form a continuous formula Process for preparing the compound of (I). 제1항에 있어서, 구조식(Ⅲ)의 2-클로로아세토니트릴을 포스포릴클로리드(POCl3)로 처리하여 구조식(Ⅳ)의 아미노클로리드 중간체를 형성시킨 뒤 이를 구조식(Ⅱ)의 2-메틸-3-(2,2,2,-트리플루오로에톡시)-1,3-부타디엔과 반응시키고 CS2를 이용하여 탈수소화시킴을 특징으로 하는 구조식(Ⅰ)의 화합물을 제조하는 방법.The process of claim 1, wherein 2-chloroacetonitrile of formula (III) is treated with phosphoryl chloride (POCl 3 ) to form an amino chloride intermediate of formula (IV) which is then 2-methyl of formula (II). A process for preparing a compound of formula (I) characterized by reacting with 3- (2,2,2, -trifluoroethoxy) -1,3-butadiene and dehydrogenating with CS 2 . 제1항에서, 구조식(Ⅱ)의 2-메틸-3-(2,2,2,-트리플루오로에톡시)-1,3-부타디엔과 구조식(Ⅲ)의 2-클로로아세토니트릴을 BCl3, AlCl3, TiCl4, SnCl4또는 ZnCl2에서 선택된 루이스산을 촉매로 하여 한 단계로 반응시킴을 특징으로 하는 구조식(Ⅰ)의 화합물을 제조하는 방법.The process of claim 1 wherein 2-methyl-3- (2,2,2, -trifluoroethoxy) -1,3-butadiene of formula (II) and 2-chloroacetonitrile of formula (III) are substituted with BCl 3 A process for preparing a compound of formula (I), characterized in that the reaction is carried out in one step using a Lewis acid selected from AlCl 3 , TiCl 4 , SnCl 4 or ZnCl 2 as a catalyst. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940014840A 1994-06-27 1994-06-27 Process for preparing pyridine derivatives KR0131051B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940014840A KR0131051B1 (en) 1994-06-27 1994-06-27 Process for preparing pyridine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940014840A KR0131051B1 (en) 1994-06-27 1994-06-27 Process for preparing pyridine derivatives

Publications (2)

Publication Number Publication Date
KR960000866A true KR960000866A (en) 1996-01-25
KR0131051B1 KR0131051B1 (en) 1998-04-17

Family

ID=19386399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940014840A KR0131051B1 (en) 1994-06-27 1994-06-27 Process for preparing pyridine derivatives

Country Status (1)

Country Link
KR (1) KR0131051B1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000063317A (en) * 2000-06-26 2000-11-06 김영렬 Composition for straight cooling
KR100395221B1 (en) * 2001-03-21 2003-08-19 송현갑 Refrigerant mixture
KR20030083248A (en) * 2002-04-19 2003-10-30 퍼스텍주식회사 Binary azeotropic-like refrigerant compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000063317A (en) * 2000-06-26 2000-11-06 김영렬 Composition for straight cooling
KR100395221B1 (en) * 2001-03-21 2003-08-19 송현갑 Refrigerant mixture
KR20030083248A (en) * 2002-04-19 2003-10-30 퍼스텍주식회사 Binary azeotropic-like refrigerant compositions

Also Published As

Publication number Publication date
KR0131051B1 (en) 1998-04-17

Similar Documents

Publication Publication Date Title
CA1262357A (en) N-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
ATE22082T1 (en) 9-THIOMAYTANSINOIDS, THEIR PRODUCTION AND USE.
KR960034204A (en) Title: Pyrido [3,2-e] pyrazinone with anti-asthmatic action and method for its preparation
UA66864C2 (en) Urea derivatives, a pharmaceutical composition and methods of treating or preventing inflammatory, autoimmune or respiratory diseases
CA1059988A (en) Process for the manufacture of enol derivatives
KR900011760A (en) Novel benzopyran derivatives, preparations thereof and pharmaceutical compositions containing said derivatives
AU591860B2 (en) Pyrolidineamide derivative having anti-prolyl endopeptidase
ES2193241T3 (en) NEW N-2-OXO2.3.4.5-TETRAJODRP-1H-1,5-BENZODIAZEPIN-3-IL) -3-AMIDAS.
EP1077218A3 (en) Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
HUP9800649A2 (en) Condesed n-heterocyclic compounds substituted with benzyloxy-group, process for producing them, and their use as bradiquinin-receptor-antagonists
DE3483920D1 (en) CONDENSED SEVEN RING CONNECTIONS, THEIR PRODUCTION AND THEIR USE.
KR850004754A (en) Method for producing 3-indole carboxamide compounds
KR960000866A (en) Method for preparing pyridine derivative
KR860001065A (en) Method for preparing 4-acetoxy-3-hydroxyethylazetizin-2-one derivative
EP0587188A3 (en) Aryl and heterocyclic substituted propenamide derivatives
SI1102765T1 (en) PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C)QUINOLIZIN-3-ONES DERIVATIVES
EP0230946A3 (en) Process for the preparation of quinolonecarboxylic acid derivatives
CA2252621A1 (en) Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid ¬2-(2h-¬1,2,4|triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl|-amide
WO1993016180A3 (en) Sequences for a 90k tumor-associated antigen, immunoregulin-95 (ir-95)
CA2054451A1 (en) Process for cleavage of esters during the production of cephalosporins
EP0137163A3 (en) 3-indolecarboxamide derivatives
KR950014071A (en) Method for preparing pyridine derivative
DE69808922D1 (en) THIAZOLOBENZOHETEROCYCLES, THEIR PRODUCTION AND THE PHATRACEUTICAL PREPARATIONS CONTAINING THEM
GB1533694A (en) Cyclopenta(b)furan-2-ol derivatives and processes for their preparation
KR840002821A (en) Method for preparing N- (2,3-epoxypropylene) -N-aralkylsulfonamide derivative

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030926

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee