KR960029227A - Sodium adenosine sodium salt 12-hydrate crystal of diadenosine - Google Patents

Sodium adenosine sodium salt 12-hydrate crystal of diadenosine Download PDF

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Publication number
KR960029227A
KR960029227A KR1019960000339A KR19960000339A KR960029227A KR 960029227 A KR960029227 A KR 960029227A KR 1019960000339 A KR1019960000339 A KR 1019960000339A KR 19960000339 A KR19960000339 A KR 19960000339A KR 960029227 A KR960029227 A KR 960029227A
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KR
South Korea
Prior art keywords
sodium
diadenosine
salt
organic solvent
hydrate
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Application number
KR1019960000339A
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Korean (ko)
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KR100195375B1 (en
Inventor
다쓰오 가타야마
요시히로 니시카와
마유미 하야시
히로시 나카지마
마사히로 오자키
다이이치 와타나베
Original Assignee
다구치 다마우즈
유니치카 가부시키가이샤
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Publication of KR960029227A publication Critical patent/KR960029227A/en
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Publication of KR100195375B1 publication Critical patent/KR100195375B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

본 발명은 다음 구조식의 디아데노신 사인산(AP4A)사나트륨염 12수화물 결정에 관한 것이다.The present invention relates to a sodium adenosine monophosphate (AP4A) sodium salt 12 hydrate crystal of the following structure.

ㆍ12H2O ㆍ 12H 2 O

기존의 무정형 무수물 AP4A사나트륨염에 비해, 본 발명의 AP4A사나트륨염 12수화물 결정은 흡습성이 낮고 물리적 특성이 매우 안정하다. 저장 도중, 이들은 외부 습도에 의해 거의 영향을 받지 않는다. 따라서, 본 발명의 결정은 약제로서 또는 약제 제조용 출발물질로서 핸들링이 용이하므로, 이의 적용 범위가 확장된다.Compared to the conventional sodium salt of amorphous anhydride AP4A, the AP4A sodium salt of the present invention has low hygroscopicity and is very stable in physical properties. During storage, these are hardly affected by external humidity. Therefore, the crystal of the present invention is easy to handle as a pharmaceutical agent or as a starting material for pharmaceutical preparation, and its application range is expanded.

Description

디아데노신 사인산 사나트륨염 12수화물 결정Di-adenosine-4-sulfonic acid sodium salt 12-hydrate crystal

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

제2도는 본 발명의 단일 디아데노신 사인산사나트륨 12수화물 결정을 X선 결정 구조 분석하여 나타낸 패턴이며, 이 도면에서 나타낸 수소 원자는 키랄성 탄소 원자에 결합된 것에 국한된다.FIG. 2 is a pattern showing an X-ray crystal structure analysis of a sodium dodecahydrate disodium hydrate crystal of a single diadenosine of the present invention, and the hydrogen atoms shown in these figures are limited to those bound to a chiral carbon atom.

Claims (11)

다음 구조식의 디아데노신 사인산사나트륨염 12수화물 결정.A sodium adenosine salt 12 hydrate crystal of diadenosine of the following structural formula. ㆍ12H2O ㆍ 12H 2 O 제1항에 있어서, 디아데노신 사인산사나트륨염 12수화물 결정의 수분 함량이 19.0% 이상인 디아데노신 사인산사나트륨염 12수화물 결정.The crystals of sodium adenosine salt 12 hydrate of diadenosine having a moisture content of not less than 19.0%, wherein the water content of the sodium adenosine salt 12 hydrate crystal is diadenosine. 제1항에 있어서, 흡습성이 0 내지 3%의 범위인 디아데노신 사인산사나트륨염 12수화물 결정.The crystals of sodium adenosyl halide 12 hydrate according to claim 1, wherein the hygroscopicity is in the range of 0 to 3%. 무정형 무수물 디아데노신 사인산사나트륨 염을 제조하는 단계, 무정형 무수물 디아데노신 사인산사나트륨 염을 정제하는 단계, 정제된 무정형 무수물 디아데노신 사인산사나트륨염의 수용액에 친수성 유기 용매를 가하는 단계 및 이로부터 디아데노신 사인산사나트륨염 12수화물 결정을 침전시키는 단계를 포함하는, 제1항에 따른 디아데노신 사인산사나트륨염 12수화물 결정의 제조방법.Which comprises the steps of preparing an acid anhydride sodium adenosine sodium salt, an amorphous anhydride diadenosine sulfonate sodium salt, an amorphous anhydride diadenosine sulfonate sodium salt, a hydrophilic organic solvent to an aqueous solution of sodium adenosine sodium salt of purified amorphous anhydride diadenosine, A process for the preparation of the sodium adenosine salt 12 hydrate crystals of diadenosine according to claim 1, comprising precipitating the oxalate sodium salt 12 hydrate crystals. 제4항에 있어서, 디아데노신 사인산사나트륨염 12수화물 결정의 수분 함량이 19.0% 이상인 방법.5. The method according to claim 4, wherein the moisture content of the sodium adenosine salt 12 hydrate crystal of diadenosine is 19.0% or more. 제4항에 있어서, 흡습성 유기 용매가 알코올, 아세톤, 디옥산 및 아세토니트릴로 이루어진 그룹 중에서 선택되는 방법.5. The process according to claim 4, wherein the hygroscopic organic solvent is selected from the group consisting of alcohols, acetone, dioxane and acetonitrile. 제4항에 있어서, 흡습성 유기 용매가 메탄올, 에탄올 및 프로판올로 이루어진 그룹 중에서 선택되는 알코올인 방법.The process according to claim 4, wherein the hygroscopic organic solvent is an alcohol selected from the group consisting of methanol, ethanol and propanol. 제7항에 있어서, 흡습성 유기 용매가 에탄올인 방법.The method according to claim 7, wherein the hygroscopic organic solvent is ethanol. 제4항에 있어서, 흡습성 유기 용매의 농도가 70% 이하인 방법.The method according to claim 4, wherein the concentration of the hygroscopic organic solvent is 70% or less. 제9항에 있어서, 흡습성 유기 용매의 농도가 20 내지 60%인 방법.The method according to claim 9, wherein the concentration of the hygroscopic organic solvent is 20 to 60%. 제10항에 있어서, 흡습성이 유기 용매의 농도가 30 내지 50%인 방법.11. The method according to claim 10, wherein the hygroscopicity is 30 to 50% of the concentration of the organic solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960000339A 1995-01-11 1996-01-10 Diadenosine tetraphosphate tetrasodium salt dodecahydrate crystals KR100195375B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP00295195A JP3487939B2 (en) 1995-01-11 1995-01-11 Diadenosine tetraphosphate tetrasodium salt dodecahydrate crystal
JP95-002951 1995-01-11

Publications (2)

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KR960029227A true KR960029227A (en) 1996-08-17
KR100195375B1 KR100195375B1 (en) 1999-06-15

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US (1) US5663322A (en)
EP (1) EP0721955B1 (en)
JP (1) JP3487939B2 (en)
KR (1) KR100195375B1 (en)
DE (1) DE69601949T2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3321462A (en) * 1963-07-15 1967-05-23 Syntex Corp Process for the preparation of nucleoside polyphosphates
JPS62278992A (en) * 1986-05-28 1987-12-03 Unitika Ltd Production of diadenosine-tetraphosphate or derivative thereof
JPH07242685A (en) * 1994-01-12 1995-09-19 Unitika Ltd Production of diadenosine tetraphosphate hydrate

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JP3487939B2 (en) 2004-01-19
EP0721955B1 (en) 1999-04-07
JPH08193095A (en) 1996-07-30
DE69601949T2 (en) 1999-08-26
DE69601949D1 (en) 1999-05-12
KR100195375B1 (en) 1999-06-15
EP0721955A2 (en) 1996-07-17
US5663322A (en) 1997-09-02
EP0721955A3 (en) 1996-08-07

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