KR960028924A - Surgical Suture Coatings - Google Patents

Surgical Suture Coatings Download PDF

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Publication number
KR960028924A
KR960028924A KR1019950000833A KR19950000833A KR960028924A KR 960028924 A KR960028924 A KR 960028924A KR 1019950000833 A KR1019950000833 A KR 1019950000833A KR 19950000833 A KR19950000833 A KR 19950000833A KR 960028924 A KR960028924 A KR 960028924A
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coating
surgical suture
weight
tbh
integer
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KR1019950000833A
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Korean (ko)
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KR0139124B1 (en
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송수석
김호현
위상백
이진환
김동래
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김상응
주식회사 삼양사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A61L17/145—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 외과용 수술용 봉합사에 열가소성 생분해성 하이드로겔(TBH)를 단독으로 코팅하거나, TBH를 20중량% 이상 함유한 코팅제 조성물로 코팅함을 특징으로 하는 외과용 봉합사용 코팅제에 관한 것이다.The present invention relates to a surgical suture coating, characterized in that the surgical suture is coated with a thermoplastic biodegradable hydrogel (TBH) alone, or coated with a coating composition containing 20% by weight or more of TBH.

Description

수술용 봉합사용 코팅제Surgical Suture Coatings

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

외과용 수술용 봉합사에 열가소성 생분해성 하이드로겔(TBH)를 단독으로, 또는 봉합사 코팅용 윤활제 80중량% 이하 TBH를 20중량% 이상 함유한 코팅제 조성물을 사용함을 특징으로 하는 외과용 봉합사용 코팅제.A surgical suture coating comprising a thermoplastic biodegradable hydrogel (TBH) alone in a surgical suture or a coating composition containing 20% by weight or more of TBH of up to 80% by weight of a suture coating lubricant. 제1항에 있어서, 외과용 수술용 봉합사는 폴리글리콜산, 폴리락트산, 글리콜라이드/락타이드 공중합체, 글리콜라이드/카프로락톤 공중합체, 폴리하이드록시부틸산, 폴리-p-다이옥산은, 트리메틸렌 카보네이트 공중합체와 같은 생체흡수성 중합체임을 특징으로 하는 외과용 봉합사용 코팅제.The surgical suture of claim 1, wherein the surgical suture is polyglycolic acid, polylactic acid, glycolide / lactide copolymer, glycolide / caprolactone copolymer, polyhydroxybutyl acid, poly-p-dioxane, trimethylene Surgical suture coating, characterized in that the bioabsorbable polymer, such as carbonate copolymer. 제1항에 있어서, 열가소성 생분해성 하이드로겔(TBH)은 하기식(I)a 내지 (I)f로 표시되는 친수성 비분해성고분자(A)와 소수성 생체 분해성 고분자(B)를 결합시켜 합성한 다중블럭 생분해성 하이드로겔 고분자임을 특징으로 하는 외과용 봉합사용 코팅제.The method of claim 1, wherein the thermoplastic biodegradable hydrogel (TBH) is synthesized by combining a hydrophilic non-degradable polymer (A) and a hydrophobic biodegradable polymer (B) represented by the following formula (I) a to (I) f Surgical suture coating, characterized in that the block biodegradable hydrogel polymer. 상기식에서 A(――)는 폴리에틸렌옥사이드(PEO) 또는 폴리에틸렌옥사이드/폴리프로필렌옥사이드 공중합체와 같은 친수성비분해성 고분자이고, (B……)는 폴리락타이드(PLA), 폴리글라이콜라이드(PGA), PLA/PGA 공중합체, 폴리카프로락톤(PCL), 폴리오르소에스터, 폴리안하이드라이드와 같은 소수성 생체 분해성 고분자이고, X는 아미드 결합, 에스테르 결합, 카보네이트 결합과 같은 생체내에서 분해되는 화학결합이고, Y는 아미드 결합, 에스테르 결합, 카보네이트 결합과 같은 A와 B,또는 B들을 공유결합에 의해 연결하는 화학결합이며, n은 0에서 10의 정수이며, q는 3에서 4의 정수이다.Wherein A (-) is a hydrophilic non-degradable polymer such as polyethylene oxide (PEO) or polyethylene oxide / polypropylene oxide copolymer, and (B ……) is polylactide (PLA), polyglycolide (PGA) , Hydrophobic biodegradable polymers such as PLA / PGA copolymer, polycaprolactone (PCL), polyorthoester, polyanhydride, X is a chemical bond that degrades in vivo such as amide bond, ester bond, carbonate bond And Y is a chemical bond connecting A and B or B such as amide bond, ester bond, carbonate bond by covalent bond, n is an integer of 0 to 10, and q is an integer of 3 to 4. 제3항에 있어서, TBH는 폴리에틸렌옥사이드(PEO), 폴리락트산(PLA), 폴리글라이콜산(PGA) 및 폴리카프로락톤(PCL)등을 포함한 다중블럭 공중합체로 하기 구조식(I) 및 (I')임을 특징으로 하는 외과용 봉합사용 코팅제.The multi-block copolymer according to claim 3, wherein TBH is a multiblock copolymer including polyethylene oxide (PEO), polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), and the like. ') Coating for surgical suture, characterized in that. 상기식에서 A는 친수성과 소수성 고분자로 이루어진 다중블럭으로서, [(CH2CH2O)n-X-(OCH2CH2)n]r이고, X는 -O(COCH2O)x-, [COCH(CH3)O]x-이며, Y는 -CHyNHCO-, Y'-는 -CONHCHy이고; R1및 R2는 수소원자이거나 메틸기이며; x는 1에서 10까지의 정수이고; z는 1에서 5까지의 정수이고; y는 0, 1, 또는 2이며; 이때 ℓ은 각각 3, 2, 1의 값을 가지고, m은 1에서 100까지의 정수이고, n은 20에서 500까지의 정수이며; k는 0에서 10까지의 정수이며; r은 0에서 10까지의 정수이다.Wherein A is a multiblock composed of hydrophilic and hydrophobic polymers, [(CH 2 CH 2 O) n -X- (OCH 2 CH 2 ) n ] r , and X is -O (COCH 2 O) x- , [ COCH (CH 3 ) O] x-, Y is -CH y NHCO-, Y'- is -CONHCH y ; R 1 and R 2 are hydrogen or methyl; x is an integer from 1 to 10; z is an integer from 1 to 5; y is 0, 1, or 2; Wherein l has a value of 3, 2, 1, m is an integer from 1 to 100, and n is an integer from 20 to 500; k is an integer from 0 to 10; r is an integer from 0 to 10. 제3항에 있어서, TBH 내의 폴리에틸렌옥사이드(PEO)의 중량비가 전체 TBH 중량대비 5% 내지 95%의 범위를갖는 것을 특징으로 하는 외과용 봉합사용 코팅제.4. The surgical suture coating of claim 3, wherein the weight ratio of polyethylene oxide (PEO) in the TBH ranges from 5% to 95% of the total TBH weight. 제1항에 있어서, 열가소성 생분해성 하이드로겔(TBH)의 함량이 전체 코팅제 중량에 대해 50중량% 이상임을특징으로 하는 외과용 봉합사용 코팅제.The surgical suture coating of claim 1, wherein the content of the thermoplastic biodegradable hydrogel (TBH) is at least 50% by weight relative to the total coating weight. 제1항에 있어서, 봉합사 코팅용 윤활제는 생체흡수성 중합체임을 특징으로 하는 외과용 봉합사용 코팅제.The surgical suture coating of claim 1, wherein the suture coating lubricant is a bioabsorbable polymer. 제7항에 있어서, 생체흡수성 중합체는 글리콜라이드 중합체, 락타이드 중합체, 글리콜라이드/락타이드 공중합체, 폴리카프로락톤, 폴리옥시알킬렌, 폴리테트라플루오르에틸렌, 실리콘수지임을 특징으로 하는 외과용 봉합사용 코팅제.8. The surgical suture of claim 7, wherein the bioabsorbable polymer is a glycolide polymer, a lactide polymer, a glycolide / lactide copolymer, polycaprolactone, polyoxyalkylene, polytetrafluoroethylene, silicone resin. Coating agent. 외과용 수술용 봉합사에 대해서 열가소성 생분해성 하이드로겔(TBH)를 단독으로 또는 TBH를 20중량% 이상함유하는 코팅제 조성물로 봉합사 중량대비 0.1∼20중량% 코팅함을 특징으로 하는 외과용 봉합사.Surgical suture for surgical surgical suture characterized in that the coating of 0.1 to 20% by weight relative to the suture weight of the thermoplastic biodegradable hydrogel (TBH) alone or a coating composition containing 20% by weight or more of TBH. 제9항에 있어서, 코팅제의 중량은 봉합사 중량대비 0.5∼10.0중량%임을 특징으로 하는 외과용 봉합사.The surgical suture according to claim 9, wherein the weight of the coating agent is 0.5 to 10.0% by weight based on the weight of the suture. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950000833A 1995-01-19 1995-01-19 Suture coating material KR0139124B1 (en)

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KR960028924A true KR960028924A (en) 1996-08-17
KR0139124B1 KR0139124B1 (en) 1998-04-28

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