KR960010617A - Novel phenylalkylamino carbamate compounds and preparation methods thereof - Google Patents
Novel phenylalkylamino carbamate compounds and preparation methods thereof Download PDFInfo
- Publication number
- KR960010617A KR960010617A KR1019940022798A KR19940022798A KR960010617A KR 960010617 A KR960010617 A KR 960010617A KR 1019940022798 A KR1019940022798 A KR 1019940022798A KR 19940022798 A KR19940022798 A KR 19940022798A KR 960010617 A KR960010617 A KR 960010617A
- Authority
- KR
- South Korea
- Prior art keywords
- structural formula
- following structural
- represented
- phenylalaninol
- carbamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 중추신경계 치료제로서 유용한 페닐알킬아미노 카바메이트 화합물과 그의 약제학적으로 유용한 염 및 그의 제조방법에 관한 것으로서, 좀 더 상세하게는 특히 항우울제 및 항불안제로서 유용한 O-카바모일 페닐알라니놀 라세미체와 그의 순수한 D- 및 L-광학이성질체, 이들의 약제학적으로 유용한 염 및 이들을 제조하는 방법에 관한 것이다.The present invention relates to a phenylalkylamino carbamate compound useful as a central nervous system therapeutic agent, a pharmaceutically useful salt thereof, and a method for preparing the same. And to pure D- and L-isomers thereof, pharmaceutically useful salts thereof, and methods of making them.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (6)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940022798A KR100197892B1 (en) | 1994-09-09 | 1994-09-09 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
CA002176012A CA2176012C (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
PCT/KR1995/000114 WO1996007637A1 (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
RU96113126/04A RU2104266C1 (en) | 1994-09-09 | 1995-09-06 | Phenylalkylamino alcohols and methods of preparing thereof |
DE69513140T DE69513140T2 (en) | 1994-09-09 | 1995-09-06 | NEW PHENYLALKYLAMINO ALCOHOL CARBAMATES AND A METHOD FOR THE PRODUCTION THEREOF |
US08/619,657 US5955499A (en) | 1994-09-09 | 1995-09-06 | Phenylalkylaminoalcohol carbamates and process for preparing the same |
JP8509386A JP2680478B2 (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylamino alcohol carbamate and method for producing the same |
AU34856/95A AU700544B2 (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
ES95931444T ES2140703T3 (en) | 1994-09-09 | 1995-09-06 | NEW PHENYLALKYLAMINO-ALCOHOL CARBAMATES AND PROCESS FOR THEIR PREPARATION. |
CN95190875A CN1069635C (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylaminoalcohol carbamates and process for prepn. of same |
EP95931444A EP0728129B1 (en) | 1994-09-09 | 1995-09-06 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940022798A KR100197892B1 (en) | 1994-09-09 | 1994-09-09 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960010617A true KR960010617A (en) | 1996-04-20 |
KR100197892B1 KR100197892B1 (en) | 1999-06-15 |
Family
ID=19392447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940022798A KR100197892B1 (en) | 1994-09-09 | 1994-09-09 | Novel phenylalkylaminoalcohol carbamates and process for preparing the same |
Country Status (11)
Country | Link |
---|---|
US (1) | US5955499A (en) |
EP (1) | EP0728129B1 (en) |
JP (1) | JP2680478B2 (en) |
KR (1) | KR100197892B1 (en) |
CN (1) | CN1069635C (en) |
AU (1) | AU700544B2 (en) |
CA (1) | CA2176012C (en) |
DE (1) | DE69513140T2 (en) |
ES (1) | ES2140703T3 (en) |
RU (1) | RU2104266C1 (en) |
WO (1) | WO1996007637A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0173862B1 (en) * | 1995-02-11 | 1999-04-01 | 조규향 | O-carbamoyl- (D) -phenylalaninol compounds and their pharmaceutically useful salts and methods for their preparation |
US20030069630A1 (en) * | 2001-03-02 | 2003-04-10 | Robert Burgermeister | Stent with radiopaque markers incorporated thereon |
CA2587481A1 (en) * | 2004-10-28 | 2006-05-11 | Sk Corporation | Phenylalkylamino carbamates adjunctive therapy for depression |
ES2435403T3 (en) | 2005-06-08 | 2013-12-19 | Sk Biopharmaceuticals Co., Ltd. | Treatment of sleep disorders and wakefulness |
EP1893291B1 (en) * | 2005-06-22 | 2010-03-03 | SK Holdings Co., Ltd. | Treatment of sexual dysfunction |
EP2079449A2 (en) * | 2006-10-13 | 2009-07-22 | Janssen Pharmaceutica, N.V. | Phenylalkylamino carbamate compositions |
US8642772B2 (en) * | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
US8741950B2 (en) * | 2009-06-22 | 2014-06-03 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating or preventing fatigue |
US8232315B2 (en) * | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
JP5836280B2 (en) * | 2009-11-06 | 2015-12-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | Treatment of Attention Deficit / Hyperactivity Disorder (ADHD) |
CN102781436B (en) | 2009-11-06 | 2014-01-08 | 爱思开生物制药株式会社 | Methods for treating fibromyalgia syndrome |
US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
HRP20221018T1 (en) | 2013-03-13 | 2023-01-06 | Jazz Pharmaceuticals Ireland Limited | Treatment of cataplexy |
KR102309836B1 (en) | 2013-07-18 | 2021-10-12 | 에스케이바이오팜 주식회사 | Treatment for obesity |
TWI698415B (en) | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | Aminocarbonylcarbamate compounds |
US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
US10195151B2 (en) * | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
CN109996540A (en) * | 2016-09-06 | 2019-07-09 | 爵士制药国际Iii有限公司 | (R) solvate forms of -2- amino -3- Phenylpropylamino formic acid esters |
ES2964943T3 (en) | 2016-10-06 | 2024-04-10 | Axsome Malta Ltd | Carbamoylphenylalaninol compounds for medical use |
WO2018133703A1 (en) * | 2017-01-20 | 2018-07-26 | 苏州科睿思制药有限公司 | Crystal form of r228060 hydrochloride and preparation method and use thereof |
AU2018278332B2 (en) | 2017-06-02 | 2022-05-19 | Jazz Pharmaceuticals Ireland Limited | Methods and compositions for treating excessive sleepiness |
US11413264B2 (en) | 2017-07-31 | 2022-08-16 | Jazz Pharmaceuticals Ireland Limited | Carbamoyl phenylalaninol analogs and uses thereof |
WO2020035769A1 (en) | 2018-08-14 | 2020-02-20 | Glenmark Pharmaceuticals Limited; Glenmark Life Sciences Limited | Process for the preparation of solriamfetol and salt thereof |
WO2021001457A1 (en) | 2019-07-04 | 2021-01-07 | Sandoz Ag | Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts |
US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
IT202000013855A1 (en) | 2020-06-10 | 2021-12-10 | Flamma Spa | A PROCESS FOR THE PURIFICATION OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE |
KR102390194B1 (en) | 2020-08-03 | 2022-04-25 | 셀라이온바이오메드 주식회사 | A composition for treating Kca3.1 channel mediated diseases comprising phenylalkyl carbamate compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1434826A (en) * | 1973-11-14 | 1976-05-05 | Gallardo Antonio Sa | Esters and carbamates of aminoalkanols |
-
1994
- 1994-09-09 KR KR1019940022798A patent/KR100197892B1/en not_active IP Right Cessation
-
1995
- 1995-09-06 EP EP95931444A patent/EP0728129B1/en not_active Expired - Lifetime
- 1995-09-06 RU RU96113126/04A patent/RU2104266C1/en active
- 1995-09-06 AU AU34856/95A patent/AU700544B2/en not_active Expired
- 1995-09-06 ES ES95931444T patent/ES2140703T3/en not_active Expired - Lifetime
- 1995-09-06 DE DE69513140T patent/DE69513140T2/en not_active Expired - Lifetime
- 1995-09-06 JP JP8509386A patent/JP2680478B2/en not_active Expired - Fee Related
- 1995-09-06 CA CA002176012A patent/CA2176012C/en not_active Expired - Lifetime
- 1995-09-06 US US08/619,657 patent/US5955499A/en not_active Expired - Lifetime
- 1995-09-06 WO PCT/KR1995/000114 patent/WO1996007637A1/en active IP Right Grant
- 1995-09-06 CN CN95190875A patent/CN1069635C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0728129B1 (en) | 1999-11-03 |
KR100197892B1 (en) | 1999-06-15 |
JPH09503231A (en) | 1997-03-31 |
DE69513140T2 (en) | 2000-08-17 |
CN1069635C (en) | 2001-08-15 |
ES2140703T3 (en) | 2000-03-01 |
DE69513140D1 (en) | 1999-12-09 |
AU3485695A (en) | 1996-03-27 |
AU700544B2 (en) | 1999-01-07 |
WO1996007637A1 (en) | 1996-03-14 |
CA2176012C (en) | 1999-01-05 |
CN1135209A (en) | 1996-11-06 |
US5955499A (en) | 1999-09-21 |
RU2104266C1 (en) | 1998-02-10 |
CA2176012A1 (en) | 1996-03-14 |
JP2680478B2 (en) | 1997-11-19 |
EP0728129A1 (en) | 1996-08-28 |
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