KR960004323A - Method for preparing 4-ethoxycarbonyl-6,7-dihydro-5H-1-pyridine - Google Patents
Method for preparing 4-ethoxycarbonyl-6,7-dihydro-5H-1-pyridine Download PDFInfo
- Publication number
- KR960004323A KR960004323A KR1019940016020A KR19940016020A KR960004323A KR 960004323 A KR960004323 A KR 960004323A KR 1019940016020 A KR1019940016020 A KR 1019940016020A KR 19940016020 A KR19940016020 A KR 19940016020A KR 960004323 A KR960004323 A KR 960004323A
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- KR
- South Korea
- Prior art keywords
- compound
- formula
- ethoxycarbonyl
- reacted
- represented
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
본 발명은 일반식(Ⅰ)로 표시되는 4-에톡시카르보닐-6,7-디히드로-5H-1-피린딘의 제조방법에 관한 것으로, 나트륨을 알콜에 녹여 만든 나트륨알콕사이드와 반응시킨 에틸시아노아세테이트와 2-할로시클로펜타논을 반응시켜 (±)-2-(1-에톡시카르보닐-1-시아노메틸)시클로펜타논(Ⅲ)을 제조하고, 이 (Ⅲ)화합물을 에테르류의 용매 하에서 포타슘t-부톡사이드와 반응시키고, 이 중간체에 알릴할로겐을 반응시켜 (±)-2-시아노-2-(시클로펜타논-2-일)펜트-4-엔-카르복실산 에틸 에테르(Ⅳ)를 제조한 후 이 화합물(Ⅳ)를 오존과 반응시켜 (±)-2-시아노-2-(시클로펜타논-2-일)부탄-4-옥소-카르복실산 에틸 에스테르(Ⅴ)를 제조하고, 이 화합물(Ⅴ)를 히드록실아민과 반응시키고 연이어 포스포러스트리클로라이드로 반응시키는 것으로 이루어진다.The present invention relates to a method for producing 4-ethoxycarbonyl-6,7-dihydro-5H-1-pyridine represented by formula (I), wherein ethyl is reacted with sodium alkoxide made by dissolving sodium in alcohol. Cyanoacetate and 2-halocyclopentanone are reacted to prepare (±) -2- (1-ethoxycarbonyl-1-cyanomethyl) cyclopentanone (III), and the compound (III) is ether Reacted with potassium t-butoxide in a solvent of the same kind, and allylhalogen was reacted with this intermediate to give (±) -2-cyano-2- (cyclopentanone-2-yl) pent-4-ene-carboxylic acid. Ethyl ether (IV) was prepared, followed by reaction of this compound (IV) with ozone to give (±) -2-cyano-2- (cyclopentanon-2-yl) butane-4-oxo-carboxylic acid ethyl ester (V) is prepared and this compound (V) is reacted with hydroxylamine and subsequently with phosphorus chloride.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940016020A KR0131993B1 (en) | 1994-07-05 | 1994-07-05 | Process for the preparation of substituted pyridine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940016020A KR0131993B1 (en) | 1994-07-05 | 1994-07-05 | Process for the preparation of substituted pyridine |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960004323A true KR960004323A (en) | 1996-02-23 |
KR0131993B1 KR0131993B1 (en) | 1998-04-17 |
Family
ID=19387295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940016020A KR0131993B1 (en) | 1994-07-05 | 1994-07-05 | Process for the preparation of substituted pyridine |
Country Status (1)
Country | Link |
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KR (1) | KR0131993B1 (en) |
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1994
- 1994-07-05 KR KR1019940016020A patent/KR0131993B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0131993B1 (en) | 1998-04-17 |
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