KR950700309A - Piperidinyl Thiacyclic Derivatives - Google Patents

Piperidinyl Thiacyclic Derivatives

Info

Publication number
KR950700309A
KR950700309A KR1019940702772A KR19940702772A KR950700309A KR 950700309 A KR950700309 A KR 950700309A KR 1019940702772 A KR1019940702772 A KR 1019940702772A KR 19940702772 A KR19940702772 A KR 19940702772A KR 950700309 A KR950700309 A KR 950700309A
Authority
KR
South Korea
Prior art keywords
piperidinyl thiacyclic
thiacyclic derivatives
derivatives
piperidinyl
treatment
Prior art date
Application number
KR1019940702772A
Other languages
Korean (ko)
Other versions
KR100269756B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR950700309A publication Critical patent/KR950700309A/en
Application granted granted Critical
Publication of KR100269756B1 publication Critical patent/KR100269756B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Piperidinyl thiacyclic derivatives <IMAGE> wherein X, Y, R1, R2, R3, and R4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT2 receptors, pharmaceutical compositions and a methods of treatment using these compounds.
KR1019940702772A 1992-02-13 1993-01-15 Piperidinyl thiacyclic derivatives KR100269756B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83565892A 1992-02-13 1992-02-13
US835658 1992-02-13
PCT/US1993/000448 WO1993016081A1 (en) 1992-02-13 1993-01-15 Piperidinyl thiacyclic derivatives

Publications (2)

Publication Number Publication Date
KR950700309A true KR950700309A (en) 1995-01-16
KR100269756B1 KR100269756B1 (en) 2000-10-16

Family

ID=25270117

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702772A KR100269756B1 (en) 1992-02-13 1993-01-15 Piperidinyl thiacyclic derivatives

Country Status (17)

Country Link
US (8) US5371093A (en)
EP (1) EP0626968B1 (en)
JP (1) JP3357879B2 (en)
KR (1) KR100269756B1 (en)
AT (1) ATE206119T1 (en)
AU (1) AU669156B2 (en)
CA (1) CA2129995C (en)
DE (1) DE69330823T2 (en)
DK (1) DK0626968T3 (en)
ES (1) ES2163407T3 (en)
FI (1) FI943727A0 (en)
HU (1) HUT71097A (en)
MX (1) MX9300603A (en)
NO (1) NO305247B1 (en)
NZ (1) NZ249286A (en)
PT (1) PT626968E (en)
WO (1) WO1993016081A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263504B (en) * 1991-10-03 1995-11-21 Pfizer
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
WO1997035480A1 (en) * 1996-03-15 1997-10-02 Eli Lilly And Company Method of treating common cold or allergic rhinitis
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
US5886003A (en) * 1996-03-25 1999-03-23 Eli Lilly And Company Methods of treating or ameliorating the symptoms of venomous bites and stings
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
ES2165274B1 (en) 1999-06-04 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
DE19939756A1 (en) * 1999-08-21 2001-02-22 Merck Patent Gmbh New 1-(1-ethyl-piperidin-4-yl)-1-(phenyl or heterocyclyl)-alkanol derivatives, are 5-HT(2A) receptor antagonists useful e.g. for treating schizophrenia, depression, memory disorders or eating disorders
RU2257384C2 (en) * 2000-02-29 2005-07-27 Мицубиси Фарма Корпорейшн New derivatives of cyclic amide
ES2172436B1 (en) * 2000-10-31 2004-01-16 Almirall Prodesfarma Sa INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
ES2201907B1 (en) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
US7302990B2 (en) * 2004-05-06 2007-12-04 General Electric Company Method of forming concavities in the surface of a metal component, and related processes and articles
RU2440993C2 (en) * 2004-10-07 2012-01-27 Вайти Фармасьютикл, Инк. Aspartic protease diaminoalkane inhibitors
TWI411607B (en) * 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc Aspartic protease inhibitors
WO2008036216A1 (en) * 2006-09-18 2008-03-27 Vitae Pharmaceuticals, Inc. Piperidine derivatives as renin inhibitors
CL2007002689A1 (en) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc COMPOUNDS DERIVED FROM PIPERIDIN-1-CARBOXAMIDA, INHIBITORS OF THE RENINE; INTERMEDIARY COMPOUNDS; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS HYPERTENSION, CARDIAC INSUFFICIENCY, CARDIAC FIBROSIS, AMONG OTHERS.
US20100160424A1 (en) * 2007-06-20 2010-06-24 Baldwin John J Renin inhibitors
EP2167609A1 (en) * 2007-06-20 2010-03-31 Vitae Pharmaceuticals, Inc. Renin inhibitors
KR101062376B1 (en) * 2008-04-10 2011-09-06 한국화학연구원 Novel indole carboxylic acid bispyridyl carboxamide derivatives, preparation method thereof and composition containing the same as an active ingredient
EP2307396A1 (en) * 2008-06-20 2011-04-13 Vitae Pharmaceuticals, Inc. Renin inhibitors and method of use thereof
CA2729052A1 (en) * 2008-06-26 2009-12-30 Vitae Pharmaceuticals, Inc. Salts of methyl 2-((r)-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3((r)-tetrahydro-2h-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
AR077692A1 (en) * 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc SALTS OF 2 - ((R) - (3-CHLOROPHENYL) ((R) -1 - ((S) -2- (METHYLAMINE) -3 - ((R) -TETRAHYDRO-2H-PIRAN-3-IL) PROPILCARBAMOIL ) PIPERIDIN -3-IL) METOXI) METHYL ETILCARBAMATE

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2526319A (en) * 1946-07-27 1950-10-17 Sprague Electric Co Thienyl ethylene compounds
NL88063C (en) * 1950-12-05
US2739969A (en) * 1952-06-09 1956-03-27 Schering Corp Substituted alkyl piperidines
NL89969C (en) * 1954-02-05
US3122561A (en) * 1959-10-19 1964-02-25 Tuskegee Inst 1-(2-thenyl)-2-di-lower alkylaminoethyl diphenylacetate and related compounds
JPS4831886B1 (en) * 1970-06-11 1973-10-02
DE2131888A1 (en) * 1971-06-24 1972-12-28 Schering Ag 5-nitrothiazole derivatives and process for their preparation
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3951998A (en) * 1974-06-17 1976-04-20 Sumitomo Chemical Company, Limited Benzothiazole derivatives
US3966748A (en) * 1975-05-08 1976-06-29 American Cyanamid Company Para-fluorophenyl-N-heterocyclic substituted butanes
US4310465A (en) * 1977-05-17 1982-01-12 Hoffmann-La Roche Inc. Synthesis of vitamin E and quinone intermediates
US4168315A (en) * 1977-09-28 1979-09-18 The Upjohn Company Dianisyl thiazole compound, compositions and method of antithrombotic treatment
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
JPS6045639B2 (en) * 1978-05-04 1985-10-11 北陸製薬株式会社 4-(dithien-2-ylmethylene)piperidine derivative
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
DE3000923A1 (en) * 1979-01-17 1980-07-31 Degussa NEW N-ALKOXY-DITHIENYL PIPERIDINE
DE3000915A1 (en) * 1979-01-17 1980-07-31 Degussa NEW DITHIENYL PIPERIDINE
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4310435A (en) * 1979-12-06 1982-01-12 The Dow Chemical Co. Method and composition for removing sulfide-containing scale from metal surfaces
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
JPS6045639A (en) * 1983-08-19 1985-03-12 日産自動車株式会社 Wefting apparatus of air jet type loom
DK159420C (en) * 1983-03-09 1991-03-11 Ciba Geigy Ag N- (PIPERIDINYL-ALKYL) CARBOXAMIDES AND SALTS THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THE USE OF THE COMPOUNDS FOR THE PREPARATION OF ANTI-CYPOTIC PHARMACEUTICAL PREPARATIONS
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
EP0181793B1 (en) * 1984-10-16 1988-07-27 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
JPS6393779A (en) * 1986-10-09 1988-04-25 Toyo Pharma- Kk Production of 4,9-dihydro-4-(1-methyl-4-piperidylidene)-10h-benzo(4,5)cyclohepta(1,2-b)-thiophen-10-one or salt thereof
EP0288973B1 (en) * 1987-04-28 1993-01-13 Fujisawa Astra Ltd. Benzothiazolinone derivatives, their production and pharmaceutical composition
JPS63270661A (en) * 1987-04-28 1988-11-08 Taki Chem Co Ltd 1-(2-(4-hydroxybenzoyl)ethanoyl)-2-piperidone, its production and alcoholic fermentation promoter containing said compound as active component
JPS6452776A (en) * 1987-05-18 1989-02-28 Hoe Yakukou Kk Benzothiazolinone derivative
US4876257A (en) * 1988-03-03 1989-10-24 Ortho Pharmaceutical Corporation 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents
JPH01227987A (en) * 1988-03-08 1989-09-12 Matsushita Electric Ind Co Ltd Human body position detector
NZ229761A (en) * 1988-07-12 1991-10-25 Ici Pharma Substituted thiazole derivatives for use as inhibitors of enzyme 5-lipoxygenase; pharmaceutical compositions and preparatory processes
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JP3003148B2 (en) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 Thiazole compound, process for producing the same, and pharmaceutical composition containing the same
US5089495A (en) * 1989-01-30 1992-02-18 Imperial Chemical Industries Plc Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives
US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
US5064840A (en) * 1989-08-03 1991-11-12 Merrell Dow Pharmaceuticals Anti-psychotic piperidylbenzimidazole compounds
FI97540C (en) * 1989-11-06 1997-01-10 Sanofi Sa Process for the preparation of therapeutically useful aromatically substituted piperidine and piperazine derivatives
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5006536A (en) * 1989-12-26 1991-04-09 Hoechst-Roussel Pharmaceuticals Inc. Thienobenzoxepins and analgesic compositions thereof
JPH03227987A (en) * 1990-01-30 1991-10-08 Taisho Pharmaceut Co Ltd Thiazole derivative
CA2093798C (en) * 1990-10-10 2000-02-01 John J. Piwinski Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
HUT64320A (en) * 1990-12-14 1993-12-28 Merrell Dow Pharma Process for production antiallergic imidazole derivatives and pharmaceutical preparations containing these compounds
EP0635012B1 (en) * 1992-03-27 1996-07-10 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
FR2702214B1 (en) * 1993-03-05 1995-04-14 Adir New (aryl (alkyl) carbonyl) -heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them.
US5384315A (en) * 1994-02-14 1995-01-24 Uniroyal Chemical Company, Inc. Thiophene substituted cycloamines, compositions and use
JPH1052776A (en) * 1996-08-06 1998-02-24 Toshiba Corp Welding method of can body and its equipment

Also Published As

Publication number Publication date
US5739150A (en) 1998-04-14
FI943727A (en) 1994-08-12
EP0626968B1 (en) 2001-09-26
US5650416A (en) 1997-07-22
NO942993L (en) 1994-08-12
US5541200A (en) 1996-07-30
US5602147A (en) 1997-02-11
NZ249286A (en) 1996-02-27
US5596003A (en) 1997-01-21
CA2129995C (en) 2000-04-11
HUT71097A (en) 1995-11-28
DE69330823T2 (en) 2002-05-02
JPH07506346A (en) 1995-07-13
WO1993016081A1 (en) 1993-08-19
NO305247B1 (en) 1999-04-26
US5631268A (en) 1997-05-20
DK0626968T3 (en) 2001-12-31
PT626968E (en) 2002-03-28
HU9402352D0 (en) 1994-10-28
US5371093A (en) 1994-12-06
NO942993D0 (en) 1994-08-12
KR100269756B1 (en) 2000-10-16
JP3357879B2 (en) 2002-12-16
AU3585593A (en) 1993-09-03
ATE206119T1 (en) 2001-10-15
EP0626968A4 (en) 1995-01-04
AU669156B2 (en) 1996-05-30
EP0626968A1 (en) 1994-12-07
MX9300603A (en) 1993-09-01
CA2129995A1 (en) 1993-08-19
FI943727A0 (en) 1994-08-12
ES2163407T3 (en) 2002-02-01
US5476861A (en) 1995-12-19
DE69330823D1 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
KR950700309A (en) Piperidinyl Thiacyclic Derivatives
SE9504661D0 (en) New compounds
FI925342A0 (en) Process for the preparation of therapeutically active (+) - - (2,3-dimethoxyphenyl) -1- [2- (4-fluorophenyl) ethyl] -4-piperidinemethanol
NO306346B1 (en) N-substituted azabicycloalkane derivatives, their use and pharmaceutical preparation
ES2154270T3 (en) NEW DERIVATIVES OF IMIDAZOL, ITS PREPARATION AND ITS THERAPEUTIC APPLICATIONS.
AP9801169A0 (en) N-hydroxy-B-sulfonyl propionamide derivatives.
ES2074846T3 (en) NEW NAFTIL-ETIL-UREAS AND NAFTIL-ETIL-TIOUREAS, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
ES2102475T3 (en) NEW HETERO-CYCLIC ALKYL-AMIDES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
RU94038064A (en) Derivatives of piperazine and piperidine, their use as antipsychotic agents, method of their synthesis, pharmaceutical composition
DK0425650T3 (en) Anti-inflammatory 4-aminophenol derivatives
DK0587088T3 (en) Substituted cyclohexane derivatives, process for their preparation and use of the compounds for the treatment of diseases
NO20020282L (en) New diphenyl-piperidine derivative
HUP0103203A2 (en) Azaadamantane derivatives and pharmaceutical compositions thereof
ES2108129T3 (en) NEW DERIVATIVES OF PIRAZINE, ITS PREPARATION AND USE.
DK0736029T3 (en) Anticonvulsant pseudofructopyranose sulfamates
KR960703863A (en) New Bis-naphthalimides for the Treatment of Cancer
YU75394A (en) ANHELED DIHYDROPYRIDINES AND THEIR APPLICATIONS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS
SE9504662D0 (en) New compounds
DE69330601D1 (en) SEROTON INERGIC ERGOLIN DERIVATIVES
SE9203824D0 (en) BENZOFURANY LIMIDAZOLE DERIVATIVES AND PROCESS FOR THE PREPARATION AND THERAPEUTICAL COMPOSITIONS CONTAINING THE SAME
TR200302031T4 (en) Substituted 1,2,3,4,5,6-Hexahydro-2,6-Methano-3-Benzazocins and their use as pharmaceutical preparations
DE60119949D1 (en) 1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BOCHINOLINE-1,10-DIONE AND THEIR USE IN THE TREATMENT OF PAIN

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
G170 Re-publication after modification of scope of protection [patent]
LAPS Lapse due to unpaid annual fee