KR950032202A - Novel anti-cancer active substance polygel produced by Polyozellus multiplex strain and its preparation method - Google Patents

Novel anti-cancer active substance polygel produced by Polyozellus multiplex strain and its preparation method Download PDF

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Publication number
KR950032202A
KR950032202A KR1019940012083A KR19940012083A KR950032202A KR 950032202 A KR950032202 A KR 950032202A KR 1019940012083 A KR1019940012083 A KR 1019940012083A KR 19940012083 A KR19940012083 A KR 19940012083A KR 950032202 A KR950032202 A KR 950032202A
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South Korea
Prior art keywords
polygel
formula
strain
produced
novel anti
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KR1019940012083A
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Korean (ko)
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KR0136447B1 (en
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유익동
송경식
황지숙
김종평
김원곤
오구택
김환묵
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김은영
한국과학기술연구원
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Priority to KR1019940012083A priority Critical patent/KR0136447B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 버섯류에 속하는 까치버섯(Polyozellus multiplex)에서 추출한 하기 구조식(I)의 신규한 항암 활성물질 폴리오젤린(polyzellin) 및 그의 제조 방법을 제공한다 :The present invention provides a novel anti-cancer active material polyzellin of the formula (I) extracted from the mushroom (Polyozellus multiplex) belonging to the mushrooms and a method for preparing the same:

Description

폴리오젤루스 속(Polyozellus multiplex)균주가 생산하는 신규 항암 활성물질 폴리오젤린 및 그 제조 방법Novel anti-cancer active substance polygel produced by Polyozellus multiplex strain and its manufacturing method

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 폴리오젤린의 자외선 흡수 스펙트럼을 도시한 것이고, 제2도는 폴리오젤린 적외선 흡수 스펙트럼을 도시한 것이고, 제3도는 폴리오젤린의 탄소 핵자기공명 스펙트럼을 도시한 것이고, 제4도는 폴리오젤린의 수소 핵자기공명 스펙트럼을 도시한 것이다.FIG. 1 shows the ultraviolet absorption spectrum of polygelins, FIG. 2 shows the polyazelin infrared absorption spectra, and FIG. 3 shows the carbon nuclear magnetic resonance spectra of polygelins, and FIG. The nuclear magnetic resonance spectrum is shown.

Claims (4)

하기 구조식(I)의 항암활성물질 폴리오젤린(polyozelline) 및 약학적으로 허용가능한 그의 염 :The anticancer active material polyozelline of the formula (I) and a pharmaceutically acceptable salt thereof: 까치 버섯을 용매로 추출함을 포함하는, 제1항의 구조식(I)의 폴리오젤린 물질의 제조 방법.A method for preparing the polygel jelly material of formula (I) according to claim 1, comprising extracting blackcurrant mushrooms with a solvent. 제2항에 있어서, 1)풍건 및 절단 단계; 2)메탄올 추출 단계; 3)벤젠 추출 단계; 4)클로로포름 추출 단계; 5)에틸 아세테이트 추출 단계; 6)농축 및 암모니아수 처리 단계; 7)메탄올 첨가 및 원심분리 단계를 포함하는 제1항의 구조식(I)의 폴리오젤린 물질의 제조 방법.According to claim 2, 1) air drying and cutting step; 2) methanol extraction step; 3) benzene extraction step; 4) chloroform extraction step; 5) ethyl acetate extraction step; 6) concentration and ammonia water treatment step; 7) A process for preparing the polygelline material of formula (I) according to claim 1, comprising the step of adding methanol and centrifuging. 유효성분으로 제1항의 구조식(I)의 폴리오젤린 물질 또는 약학적으로 허용가능한 염 및 약학적으로 허용 가능한 담체를 포함하는 약한 조성물.A weak composition comprising the polygel jelly material or pharmaceutically acceptable salt of formula (I) as an active ingredient and a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940012083A 1994-05-31 1994-05-31 Novel activity polyozellus having anti-cancer activity produced by a strain of polyozellus multiplex and a process for producing them KR0136447B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940012083A KR0136447B1 (en) 1994-05-31 1994-05-31 Novel activity polyozellus having anti-cancer activity produced by a strain of polyozellus multiplex and a process for producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940012083A KR0136447B1 (en) 1994-05-31 1994-05-31 Novel activity polyozellus having anti-cancer activity produced by a strain of polyozellus multiplex and a process for producing them

Publications (2)

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KR950032202A true KR950032202A (en) 1995-12-20
KR0136447B1 KR0136447B1 (en) 1998-04-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200117501A (en) 2019-04-04 2020-10-14 한국과학기술연구원 Composition for improving damages of neuronal cells or inhibiting apoptosis of neuronal cells

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101457869B1 (en) * 2012-11-15 2014-11-07 강원도 Composition for controlling plant viruses comprising Polyozellus multiplex extracts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200117501A (en) 2019-04-04 2020-10-14 한국과학기술연구원 Composition for improving damages of neuronal cells or inhibiting apoptosis of neuronal cells

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