KR950000881A - Nucleotide Sequences and Amino Acid Sequences Inferred from the New Korean Hepatitis C Virus CDD - Google Patents

Nucleotide Sequences and Amino Acid Sequences Inferred from the New Korean Hepatitis C Virus CDD Download PDF

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Publication number
KR950000881A
KR950000881A KR1019930009914A KR930009914A KR950000881A KR 950000881 A KR950000881 A KR 950000881A KR 1019930009914 A KR1019930009914 A KR 1019930009914A KR 930009914 A KR930009914 A KR 930009914A KR 950000881 A KR950000881 A KR 950000881A
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South Korea
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hepatitis
korean
nucleotide sequence
fragment
virus
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KR1019930009914A
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Korean (ko)
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KR100361885B1 (en
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조중명
박영우
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최근선
주식회사 럭키
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251—Methods of production or purification of viral material

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 한국형 비A비B형 간염(Non-A, Non-B Hepatitis, NANBH) 환자로부터 얻은 새로운 형의 C형 간염 바이러스(hepatitis C virus)의 cDNA 유전자 절편들 및 이들 절편에 코오드화된 아미노산 서열을 갖는 폴리펩티드, 상기 cDNA 유전자 절편을 포함하는 벡터, 상기 벡터로 형질전환된 미생물 및 상기 미생물을 배양하여 새로운 한국형 C형 간염 바이러스의 cDNA에 코오드화된 폴리펩티드 또는 그 절편을 제조하는 방법에 관한 것이다.The present invention relates to cDNA gene fragments of a new type of hepatitis C virus obtained from a Korean non-A hepatitis (NANBH) patient and an amino acid encoded by these fragments. A polypeptide having a sequence, a vector comprising the cDNA gene fragment, a microorganism transformed with the vector and the microorganism are cultured to produce a polypeptide encoded by the cDNA of a new Korean hepatitis C virus or a fragment thereof. .

Description

새로운 한국형 씨(C)형 간염 바이러스 씨디엔에이(cDNA) 절편의 뉴클레오티드 서열 및 이로부터 유추된 아미노산 서열Nucleotide Sequences and Amino Acid Sequences Inferred from the New Korean Hepatitis C Virus CDD

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 단편 4F4의 뉴클레오티드 서열 및 이로부터 유추된 아미노산 서열.Figure 1 shows the nucleotide sequence of fragment 4F4 and the amino acid sequence inferred therefrom.

Claims (19)

제1도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean hepatitis C virus cDNA or fragment thereof having the nucleotide sequence of FIG. 제1도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.A polypeptide or fragment thereof encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제2도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean type hepatitis C virus cDNA having a nucleotide sequence of FIG. 2 or a fragment thereof. 제2도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.Polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제3도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean hepatitis C virus cDNA having a nucleotide sequence of FIG. 3 or a fragment thereof. 제3도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.A polypeptide or fragment thereof encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 3. 제4도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean hepatitis C virus cDNA having a nucleotide sequence of FIG. 4 or a fragment thereof. 제4도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.A polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 4 or a fragment thereof. 제5도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean hepatitis C virus cDNA having a nucleotide sequence of FIG. 5 or a fragment thereof. 제5도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.Polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제6도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean type hepatitis C virus cDNA having a nucleotide sequence of FIG. 6 or a fragment thereof. 제6도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.Polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제7도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean type hepatitis C virus cDNA having a nucleotide sequence of FIG. 7 or a fragment thereof. 제7도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.Polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제8도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean type hepatitis C virus cDNA having a nucleotide sequence of FIG. 8 or a fragment thereof. 제8도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.A polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 8 or a fragment thereof. 제1도 내지 제8도중 어느 하나의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편을 포함하는 벡터.A vector comprising a Korean-type hepatitis C virus cDNA having a nucleotide sequence of any one of FIGS. 1 to 8 or a fragment thereof. 제17항의 벡터에 의해 형질전환된 미생물.A microorganism transformed with the vector of claim 17. 제18항의 미생물을 배양하여 제1도 내지 제8도중 어느 하나의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편을 제조하는 방법.19. A method of culturing the microorganism of claim 18 to prepare a polypeptide or fragment thereof encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of any one of FIGS. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930009914A 1993-06-02 1993-06-02 Nucleotide sequences of korean hepatitis c virus cdna fragments and amino acid sequences deduced therefrom KR100361885B1 (en)

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