KR950000880A - Total Nucleotide Sequences and Amino Acid Sequences Inferred from KHCV-L2, a Type of Korean Hepatitis C Virus - Google Patents

Total Nucleotide Sequences and Amino Acid Sequences Inferred from KHCV-L2, a Type of Korean Hepatitis C Virus Download PDF

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Publication number
KR950000880A
KR950000880A KR1019930009913A KR930009913A KR950000880A KR 950000880 A KR950000880 A KR 950000880A KR 1019930009913 A KR1019930009913 A KR 1019930009913A KR 930009913 A KR930009913 A KR 930009913A KR 950000880 A KR950000880 A KR 950000880A
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South Korea
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virus
fragment
hepatitis
khcv
amino acid
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KR1019930009913A
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Korean (ko)
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KR100361884B1 (en
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조중명
박영우
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최근선
주식회사 럭키
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251—Methods of production or purification of viral material

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 한국형 비 A 비 B형 간염(Non-A, Non-B Hepatitis, NANBH) 환자로부터 얻은 KHCV-L2로 명명된 한 종류의 NANBH 바이러스 또는 C형 간염 바이러스(Hepatitis C Virus)의 부분 또는 전체 cDNA 유전자의 뉴클레오티드서열 및 그로부터 유추된 아미노산 서열, 상기 cDNA 유전자 또는 그 절편을 포함하는 벡터, 상기 벡터로 형질전환된 미생물 및 상기 그 절편을 포함하는 벡터, 상기 벡터로 형질전환된 미생물 및 상기 미생물을 배양하여 새로운 한국형 C형 간염 바이러스의 cDNA에 코오드화된 폴리펩티드 또는 그 절편을 제조하는 방법에 관한 것이다.The present invention is part or all of one type of NANBH virus or Hepatitis C Virus named KHCV-L2 obtained from Non-A, Non-B Hepatitis (NANBH) patients. Nucleotide sequence of the cDNA gene and the amino acid sequence inferred therefrom, the vector comprising the cDNA gene or fragment thereof, the microorganism transformed with the vector and the vector comprising the fragment, the microorganism transformed with the vector and the microorganism The present invention relates to a method for producing a polypeptide encoded by cDNA of a new Korean hepatitis C virus or a fragment thereof.

Description

한국형 씨(C)형 간염 바이러스의 일종인 케이에이치씨브이-엘2(KHCV-L2)의 전체 뉴클레오티드서열 및 이로부터 유추된 아미노산 서열Total Nucleotide Sequences and Amino Acid Sequences Inferred from KHCV-L2, a Type of Korean Hepatitis C Virus

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 단편 B1의 뉴클레오티드서열 및 이로부터 유추된 아미노산서열이다.1 is the nucleotide sequence of fragment B1 and the amino acid sequence deduced therefrom.

Claims (7)

제17도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편.Korean hepatitis C virus cDNA having a nucleotide sequence of FIG. 17 or a fragment thereof. 제17도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편.Polypeptide encoded by the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 제1항에 있어서, 제1도 내지 제16도중 어느 하나의 뉴클레오티드 서열을 갖는 cDNA 또는 그 절편.The cDNA of claim 1 or a fragment thereof having the nucleotide sequence of any one of FIGS. 1 to 16. 제2항에 있어서, 제1도 내지 제15도중 어느 하나의 뉴클레오티드 서열을 갖는 cDNA에 코오드화된 폴리펩티드 또는 그 절편.The polypeptide or fragment thereof of claim 2 encoded by cDNA having the nucleotide sequence of any one of FIGS. 1 to 15. 제17도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA 또는 그 절편을 포함하는 벡터.A vector comprising the Korean hepatitis C virus cDNA having a nucleotide sequence of FIG. 17 or a fragment thereof. 제5항에 벡터에 의해 형질전환된 미생물.The microorganism transformed by the vector of Claim 5. 제6항의 미생물을 배양하여 제17도의 뉴클레오티드 서열을 갖는 한국형 C형 간염 바이러스 cDNA에 코오드화된 폴리펩티드 또는 그 절편을 제조하는 방법.A method of producing a polypeptide or a fragment thereof encoded in the Korean hepatitis C virus cDNA having the nucleotide sequence of FIG. 17 by culturing the microorganism of claim 6. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930009913A 1993-06-02 1993-06-02 Total nucleotide sequence of korean type hepatitis c virus khcv-l2 and the amino acid sequence deduced therefrom KR100361884B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930009913A KR100361884B1 (en) 1993-06-02 1993-06-02 Total nucleotide sequence of korean type hepatitis c virus khcv-l2 and the amino acid sequence deduced therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930009913A KR100361884B1 (en) 1993-06-02 1993-06-02 Total nucleotide sequence of korean type hepatitis c virus khcv-l2 and the amino acid sequence deduced therefrom

Publications (2)

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KR950000880A true KR950000880A (en) 1995-01-03
KR100361884B1 KR100361884B1 (en) 2003-05-09

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970010787A (en) * 1995-08-14 1997-03-27 성재갑 Fusion protein comprising hepatitis B virus surface antigen and hepatitis C virus envelope protein and mixed vaccine comprising the same
KR970065716A (en) * 1996-03-19 1997-10-13 성재갑 The secretory envelope proteins 1 and 2 of the hepatitis C virus (Korean type)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970010787A (en) * 1995-08-14 1997-03-27 성재갑 Fusion protein comprising hepatitis B virus surface antigen and hepatitis C virus envelope protein and mixed vaccine comprising the same
KR970065716A (en) * 1996-03-19 1997-10-13 성재갑 The secretory envelope proteins 1 and 2 of the hepatitis C virus (Korean type)

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Publication number Publication date
KR100361884B1 (en) 2003-05-09

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