KR940008683A - Fast dissolving injectable cepyramid preparations - Google Patents

Fast dissolving injectable cepyramid preparations Download PDF

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Publication number
KR940008683A
KR940008683A KR1019920018629A KR920018629A KR940008683A KR 940008683 A KR940008683 A KR 940008683A KR 1019920018629 A KR1019920018629 A KR 1019920018629A KR 920018629 A KR920018629 A KR 920018629A KR 940008683 A KR940008683 A KR 940008683A
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KR
South Korea
Prior art keywords
injection
organic solvent
fast dissolving
solution
ceftyramide
Prior art date
Application number
KR1019920018629A
Other languages
Korean (ko)
Other versions
KR950010155B1 (en
Inventor
김정우
곽효성
신희종
임희원
민경복
Original Assignee
김상조
주식회사 종근당
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 김상조, 주식회사 종근당 filed Critical 김상조
Priority to KR1019920018629A priority Critical patent/KR950010155B1/en
Publication of KR940008683A publication Critical patent/KR940008683A/en
Application granted granted Critical
Publication of KR950010155B1 publication Critical patent/KR950010155B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Abstract

본 발명은 세팔로스포린제 항새제인 세프피라마이드나트륨의 속용해성 주사제 및 그의 제조방법에 관한 것으로, 정제수 적량에 중탄산나트륨을 넣고 완전히 용해한 후 세프피라마이드를 서서히 가하면서 반응시켜 세프피라마이드나트륨을 형성한 용액에, 알코올 또는 적당한 유기용매를 가하여 물과 유기용매의 혼합용액을 조제한 후 멸균바이알에 1회 투여용량을 충진 또는 다른 적당한 용기에 넣어 냉동건조하여 만드는 것을 특징으로 하는 주사제.이다.The present invention relates to a fast dissolving injectable solution of cefepyramid sodium, a cephalosporin agent antipyretic, and a method for preparing the same. An injection is characterized by preparing a mixed solution of water and an organic solvent by adding alcohol or a suitable organic solvent to one solution, and then freeze-drying a single dose in a sterile vial or in another suitable container.

이는 사용시 빠른 속도로 소량의 주사용액에 용해할 수 있도록, 품질의 변화없이 장기간 보존할 수 있는 잇점이 있다.This has the advantage that it can be stored for a long time without any change in quality so that it can be dissolved in a small amount of the injection solution at high speed in use.

Description

속용해성 주사용 세프피라마이드 주사제.Fast dissolving injectable cepyramid injections.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1a도 내지 제1b도는 본 발명에 따르는 주사제.와 기존의 주사제.와의 입자 크기를 비교하여 나타낸 사진이다.1a to 1b are photographs showing the particle size of the injection according to the present invention and the conventional injection.

Claims (4)

정제수 적량에 중탄산나트륨을 넣고 완전히 용해한 후 세프피라마이드를 서서히 가하면서 반응시켜 세프피라마이드나트륨을 형성한 용액에, 알코올 또는 적당한 유기용매를 가하여 물과 유기용매의 혼합용액을 조제한 후 멸균 바이알에 1회 투여용량을 충진 또는 다른 적당한 용기에 넣어 냉동건조한 속용해성 세프피라마이드 주사제.Sodium bicarbonate was added to the purified water and dissolved completely, followed by slowly adding ceftyramid. The solution was formed with sodium ceftyramid, and alcohol or a suitable organic solvent was added to prepare a mixed solution of water and organic solvent. A lyophilized ceftyramide injection, freeze-dried, in a single dose or other suitable container. 제1항에 있어서, 유기용매가 메탄올, 이소프로필알콜, 부탄올, 아세토니트릴, 에탄올 및 아세톤 중에서 선택된 것인 속용해성 세프피라마이드 주사제.The fast dissolving ceftyramide injection of claim 1, wherein the organic solvent is selected from methanol, isopropyl alcohol, butanol, acetonitrile, ethanol and acetone. 제1항에 있어서, 유기용매가 에탄올인 속용해성 세프피라마이드 주사제.The fast dissolving ceftyramide injection of Claim 1 whose organic solvent is ethanol. 제1항에 있어서, 물과 에탄올의 혼합비율이 90:10 내지 97:3인 속용해성 세프피라마이드 주사제.The fast dissolving ceftyramide injection of claim 1, wherein the mixing ratio of water and ethanol is 90:10 to 97: 3. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920018629A 1992-10-10 1992-10-10 Sefpyramide preparation for rapid soluble injection KR950010155B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920018629A KR950010155B1 (en) 1992-10-10 1992-10-10 Sefpyramide preparation for rapid soluble injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920018629A KR950010155B1 (en) 1992-10-10 1992-10-10 Sefpyramide preparation for rapid soluble injection

Publications (2)

Publication Number Publication Date
KR940008683A true KR940008683A (en) 1994-05-16
KR950010155B1 KR950010155B1 (en) 1995-09-11

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Application Number Title Priority Date Filing Date
KR1019920018629A KR950010155B1 (en) 1992-10-10 1992-10-10 Sefpyramide preparation for rapid soluble injection

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1305877C (en) * 2004-07-07 2007-03-21 广州白云山医药科技发展有限公司 Process for preparing cefpiramide sodium
CN100336510C (en) * 2004-09-30 2007-09-12 广州白云山天心制药股份有限公司 Cefpiramide composition

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Publication number Publication date
KR950010155B1 (en) 1995-09-11

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