KR930019626A - Novel acetamide derivatives and uses thereof - Google Patents

Novel acetamide derivatives and uses thereof Download PDF

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Publication number
KR930019626A
KR930019626A KR1019930003148A KR930003148A KR930019626A KR 930019626 A KR930019626 A KR 930019626A KR 1019930003148 A KR1019930003148 A KR 1019930003148A KR 930003148 A KR930003148 A KR 930003148A KR 930019626 A KR930019626 A KR 930019626A
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KR
South Korea
Prior art keywords
acetamide
piperidinomethyl
phenoxy
propyl
trans
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KR1019930003148A
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Korean (ko)
Inventor
마사기 오다기리
데루꼬 이마이
Original Assignee
쇼노 가쯔야
유끼지루시유교 가부시끼가이샤
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Application filed by 쇼노 가쯔야, 유끼지루시유교 가부시끼가이샤 filed Critical 쇼노 가쯔야
Publication of KR930019626A publication Critical patent/KR930019626A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-치환-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드, 그 유도체 및 이들의 약리상 허용되는 염.2-substituted-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide, derivatives thereof and pharmacologically acceptable salts thereof.

치환기로서는 아미노메틸시클로헥산카로보닐기 또는 N-카르보벤족시-p-아미노메틸헥산카르보닐기가 있다.Examples of the substituent include an aminomethylcyclohexanecarbonyl group or an N-carbenzoxy-p-aminomethylhexanecarbonyl group.

전자의 치환기를 갖는 화합물은 항 궤양제의 유효성분이며, 후자의 기를 갖는 화합물은 그 중간체로 된다.The compound which has the former substituent is an active ingredient of an antiulcer agent, and the compound which has the latter group becomes the intermediate.

상기 화합물은 유효성분으로 하는 항 궤양약.The compound is an antiulcer drug as an active ingredient.

위산분비 억제작용 및 위점막 보호작용의 두 작용을 병유(倂有)하여 궤양의 억제 및 치유에 유용하다.It is useful for suppressing and healing ulcers by combining two functions of gastric acid secretion inhibitory action and gastric mucosa protective action.

Description

신규의 아세트아미드 유도체 및 그 용도Novel acetamide derivatives and uses thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명의 화합물, 2-(트란스-p-아미노메틸시클로헥산카르복시)-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드의 적의 흡수 스펙트럼(2R)을 표시한다.FIG. 1 shows the absorption spectrum of an enemy of the compound of the invention, 2- (trans-p-aminomethylcyclohexanecarboxy) -N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide ( 2R).

제2도는 동화합물의 NMR을 표시한다.2 shows the NMR of the same compound.

제3도는 동화합물의 질량 스펙트럼을 표시한다.3 shows the mass spectrum of the compound.

Claims (8)

다음식으로 표시되는 2-치환-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드, 그 유도체 및 이들의 약리상 허용되는 염.2-substituted-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide represented by the following formula, derivatives thereof and pharmacologically acceptable salts thereof. [단, 식중 R은, 아미노메틸시클로헥산카르보닐기][Wherein R is an aminomethylcyclohexanecarbonyl group] 2-(트란스-p-아미노메틸시클로헥산카르복시)-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드.2- (trans-p-aminomethylcyclohexanecarboxy) -N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide. 2-(N-카르보벤족시-트란스-p-아미노메틸헥산카르복시)-2-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드.2- (N-carbobenzoxy-trans-p-aminomethylhexanecarboxy) -2-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide. 다음식으로 표시돼 있는 2-치환-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드, 그 유도체 및 이들의 약리상 허용되는 염과 의약상 허용되는 담체로서의 의약조성물.2-substituted-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide, its derivatives and their pharmacologically acceptable salts and pharmaceutically acceptable carriers represented by the formula As a pharmaceutical composition. [단, 식중 R은 아미노메틸시클로헥산카르보닐기][Wherein R is an aminomethylcyclohexanecarbonyl group] 다음식으로 표시되는 2-(아미노메틸시클로헥산카르복시)-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드, 그 유도체 및 이들의 약리상 허용되는 염을 유효성분으로 하는 항 궤양약.2- (aminomethylcyclohexanecarboxy) -N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide, a derivative thereof and a pharmacologically acceptable salt thereof represented by the following formula: Anti-ulcer drugs made as an active ingredient. 2-(트란스-p-아미노메틸시클로헥산카르복시)-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드인 청구항(5)에 의한 항 궤양제.The antiulcer agent according to claim (5), which is 2- (trans-p-aminomethylcyclohexanecarboxy) -N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide. 다음식으로 표시되는 2-(N-카르보벤족시-트란스-p-아미노메틸헥산카르복시)-2-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드인 중간체.2- (N-carbobenzoxy-trans-p-aminomethylhexanecarboxy) -2-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide represented by the following formula: Phosphorus Intermediates. 아세트아미드가, 2-(N-카르보벤족시-트란스-p-아미노메틸헥산카르복시)-2-N-{3-[3-(1-피페리디노메틸)페녹시]프로필}아세트아미드인 중간체.Acetamide is 2- (N-carbobenzoxy-trans-p-aminomethylhexanecarboxy) -2-N- {3- [3- (1-piperidinomethyl) phenoxy] propyl} acetamide Intermediate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930003148A 1992-03-04 1993-03-04 Novel acetamide derivatives and uses thereof KR930019626A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8286492 1992-03-04
JP92-082864 1992-03-04

Publications (1)

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KR930019626A true KR930019626A (en) 1993-10-18

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CA (1) CA2090802A1 (en)
ZA (1) ZA931546B (en)

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CA2090802A1 (en) 1993-09-05
ZA931546B (en) 1993-09-27

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