KR930013093A - New microorganisms produce L-lysine - Google Patents

New microorganisms produce L-lysine Download PDF

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Publication number
KR930013093A
KR930013093A KR1019910024681A KR910024681A KR930013093A KR 930013093 A KR930013093 A KR 930013093A KR 1019910024681 A KR1019910024681 A KR 1019910024681A KR 910024681 A KR910024681 A KR 910024681A KR 930013093 A KR930013093 A KR 930013093A
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KR
South Korea
Prior art keywords
lysine
leucine
corynebacterium glutamicum
kfcc
azaleucine
Prior art date
Application number
KR1019910024681A
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Korean (ko)
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KR940001307B1 (en
Inventor
김성준
박상범
김용의
조영제
이재흥
Original Assignee
김정순
제일제당 주식회사
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Priority to KR1019910024681A priority Critical patent/KR940001307B1/en
Publication of KR930013093A publication Critical patent/KR930013093A/en
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Publication of KR940001307B1 publication Critical patent/KR940001307B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 미생물을 이용한 L-라이산의 제조방법에 관한 것으로 L-라이신 생산변이주인 코리네박테리움 글루타이쿰 KFCC 10014를 변이처리하여, L-루이신 유사체인 4-아자루이신에 내성을 지닌 균주(코리네박테리움 글루타이쿰 KFCC 10750)를 얻은 다음, 이 균주를 당이 함유된 발효배지에서 배양하여, L-루이신에 대한 L-라이신 생산저해를 방지하면은 배양액에 L-라이신을 직접 축적시키을 특징으로 하는 L-라이신의 제조방법에 관한 것이다.The present invention relates to a method for producing L-lysine using a microorganism, and mutated to Corynebacterium glutaicum KFCC 10014, a L-lysine production variant, to tolerate 4-azaleucine, an L-leucine analog. The strain (Corinebacterium glutacum KFCC 10750) was obtained, and the strain was cultured in a fermentation medium containing sugar to prevent the inhibition of L-lysine production for L-leucine. It relates to a method for producing L- lysine, characterized in that directly accumulate.

Description

L-라이신을 생산하는 신규 미생물New microorganisms produce L-lysine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

호모세린 영양요구성과 L-루이신 유사체인 4-아자루이신 및 항생제의 일종인 리팜피신에 대하여 내성을 지닌 L-라이신 생산능이 있는 코리네박테리움 글루타미쿰 미생물.Corynebacterium glutamicum microorganisms having L-lysine production capacity that are resistant to homoserine nutrient composition and L-leucine analogues, 4-azaleucine, and a type of antibiotic, rifampicin. 제1항에 있어서,코리네박테리움 글루타미쿰은 L-루이신 유사체인 4-아자루이신에 대해 500-1,000㎎/ㅣ범위에서 내성을 지니며,발효과정에서 배양액에 100mg/l이하의 L-루이신을 축적시킴을 특징으로 하는 미생물.The method of claim 1, Corynebacterium glutamicum is resistant to the L- leucine analog 4-azaleucine in the range of 500-1,000 mg / l, less than 100 mg / l to the culture in the foot effect tablets A microorganism characterized by accumulating L-leucine. 제1항에 있어서, 코리네박테리움 글루타미쿰은 코리네박테리움 글루타미쿰 CS13(KFCC 10750)임을 특징으로 하는 미생물.The microorganism of claim 1, wherein Corynebacterium glutamicum is Corynebacterium glutamicum CS13 (KFCC 10750). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910024681A 1991-12-27 1991-12-27 Microorganism for producing l-lysine KR940001307B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910024681A KR940001307B1 (en) 1991-12-27 1991-12-27 Microorganism for producing l-lysine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910024681A KR940001307B1 (en) 1991-12-27 1991-12-27 Microorganism for producing l-lysine

Publications (2)

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KR930013093A true KR930013093A (en) 1993-07-21
KR940001307B1 KR940001307B1 (en) 1994-02-19

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KR1019910024681A KR940001307B1 (en) 1991-12-27 1991-12-27 Microorganism for producing l-lysine

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102277034B1 (en) * 2021-01-29 2021-07-13 씨제이제일제당 (주) Novel 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase variant and a method for producing L-lysine using the same

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100273950B1 (en) * 1998-09-22 2001-01-15 손경식 Corynebacterium glutamicum CJ31-0210 producing L-lysine and method for producing L-lysine using the same
KR101498630B1 (en) 2013-10-28 2015-03-04 씨제이제일제당 주식회사 A microorganism of corynebacterium genus having enhanced L-lysine productivity and a method for producing L-lysine using the same
KR101565770B1 (en) 2013-12-13 2015-11-04 씨제이제일제당 주식회사 A corynebacterium microorganism having enhanced L-lysine productivity and a method of producing L-lysine using the same
KR101601404B1 (en) 2014-04-09 2016-03-09 씨제이제일제당 (주) A microorganism having enhanced L-lysine productivity and a method of producing L-lysine using the same
KR101776375B1 (en) 2015-03-18 2017-09-08 씨제이제일제당 (주) Pyruvate dehydrogenase variants, a microorganism comprising the same and a method for producing L-amino acid using the same
KR101793328B1 (en) 2015-07-03 2017-11-03 씨제이제일제당 (주) A microorganism having enhanced L-lysine productivity and a method of producing L-lysine using the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102277034B1 (en) * 2021-01-29 2021-07-13 씨제이제일제당 (주) Novel 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase variant and a method for producing L-lysine using the same
WO2022163916A1 (en) * 2021-01-29 2022-08-04 씨제이제일제당 (주) Novel dahp synthase variant, and method for producing l-lysine using same

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