KR930012670A - Method for preparing methyl-3,4-dihydroxy-5-methoxy benzoate - Google Patents

Method for preparing methyl-3,4-dihydroxy-5-methoxy benzoate Download PDF

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Publication number
KR930012670A
KR930012670A KR1019910025394A KR910025394A KR930012670A KR 930012670 A KR930012670 A KR 930012670A KR 1019910025394 A KR1019910025394 A KR 1019910025394A KR 910025394 A KR910025394 A KR 910025394A KR 930012670 A KR930012670 A KR 930012670A
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South Korea
Prior art keywords
dihydroxy
methoxy benzoate
methyl
added
methoxy
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KR1019910025394A
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Korean (ko)
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KR950005767B1 (en
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김승조
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김중길
아주약품공업 주식회사
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Priority to KR1019910025394A priority Critical patent/KR950005767B1/en
Publication of KR930012670A publication Critical patent/KR930012670A/en
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Publication of KR950005767B1 publication Critical patent/KR950005767B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 다음 구조식(Ⅰ)로 표시되는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법에 관한 것으로서, 갈릭애시드를 물과 유기용매와의 혼합용매에 용해한 후 붕사로서 3,4-위치의 수산기를 보호하고 알카리화제와 알킬화제를 동시에 적하하여 에스테르화 및 알킬화한 후 산처리하므로써, 의 약품 및 화학약품의 중간체로 이용되는 메칠-3,4-디히드록시-5-메톡시 벤조레이트를 간편하고 경제적인 방법에 의해 고수율로 제조하는 방법에 관한 것이다.The present invention relates to a method for producing methyl-3,4-dihydroxy-5-methoxy benzoate represented by the following structural formula (I), wherein the garlic acid is dissolved in a mixed solvent of water and an organic solvent and then borax. Methyl-3,4-dihydroxy-5- which is used as an intermediate in pharmaceuticals and chemicals by protecting the 3,4-position hydroxyl group, and simultaneously dropping the alkaline and alkylating agents, esterifying and alkylating them A method for preparing methoxy benzoate in high yield by a simple and economic method.

Description

메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법Method for preparing methyl-3,4-dihydroxy-5-methoxy benzoate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

갈릭애시드로부터 메칠-3,4-디하이드록시-5-메톡시 벤조레이트를 제조함에 있어서, 갈릭애시드를 물과 유기용매와의 혼합용매에 용해하고 붕사를 첨가한 다음, 알킬화제와 알카리화제를 동시에 첨가하여 pH를 8∼9로 유지하면서 반응시키는 단일공정으로 제조함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.In preparing methyl-3,4-dihydroxy-5-methoxy benzoate from garlic acid, the garlic acid is dissolved in a mixed solvent of water and an organic solvent, borax is added, and then an alkylating agent and an alkalizing agent are simultaneously used. A method for producing methyl-3,4-dihydroxy-5-methoxy benzoate, which is prepared in a single step of adding and reacting while maintaining the pH at 8-9. 제1항에 있어서, 상기 혼합용매중의 유기용매로는 메탄올, 에탄올, 아세톤 또는 아세토니트링를 사용함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.The method of claim 1, wherein the organic solvent in the mixed solvent is methanol, ethanol, acetone or acetonitrile. The method for producing methyl-3,4-dihydroxy-5-methoxy benzoate. 제1항에 있어서, 상기 붕사는 상기 갈릭애시드에 대해 2∼2.5배의 몰비율로 첨가함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.The method of claim 1, wherein the borax is added at a molar ratio of 2 to 2.5 times with respect to the garlic acid. The method for producing methyl-3,4-dihydroxy-5-methoxy benzoate. 제1항에 있어서, 상기 알킬화제로서는 디메칠설페이트를 사용함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.The method for producing methyl-3,4-dihydroxy-5-methoxy benzoate according to claim 1, wherein dimethyl sulfate is used as the alkylating agent. 제1항 또는 제4항에 있어서, 상기 알킬화제는 상기 갈릭에시드에 대해 4∼6배의 몰비율로 첨가함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.5. The preparation of methyl-3,4-dihydroxy-5-methoxy benzoate according to claim 1 or 4, wherein the alkylating agent is added at a molar ratio of 4 to 6 times the gallic acid. Way. 제1항에 있어서, 상기 알카리화제로서는 소다움카보네이트 또는 포타슘카네이트를 사용함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.The method for preparing methyl-3,4-dihydroxy-5-methoxy benzoate according to claim 1, wherein sodium carbonate or potassium carbonate is used as the alkalizing agent. 제1항 또는 제6항에 있어서, 상기 알카리화제는 상기 갈리애시드에 대해 4∼6배의 몰비율로 첨가함을 특징으로 하는 메칠-3,4-디하이드록시-5-메톡시 벤조레이트의 제조방법.7. The method according to claim 1 or 6, wherein the alkalizing agent is added at a molar ratio of 4 to 6 times relative to the gallic acid of methyl-3,4-dihydroxy-5-methoxy benzoate. Manufacturing method. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910025394A 1991-12-30 1991-12-30 Preparation of methyl-3,4-dihydroxy-5-methoxy benzoate KR950005767B1 (en)

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Application Number Priority Date Filing Date Title
KR1019910025394A KR950005767B1 (en) 1991-12-30 1991-12-30 Preparation of methyl-3,4-dihydroxy-5-methoxy benzoate

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Application Number Priority Date Filing Date Title
KR1019910025394A KR950005767B1 (en) 1991-12-30 1991-12-30 Preparation of methyl-3,4-dihydroxy-5-methoxy benzoate

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KR930012670A true KR930012670A (en) 1993-07-21
KR950005767B1 KR950005767B1 (en) 1995-05-30

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