KR930010000A - Method for preparing pyridine derivative - Google Patents

Method for preparing pyridine derivative Download PDF

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Publication number
KR930010000A
KR930010000A KR1019910020103A KR910020103A KR930010000A KR 930010000 A KR930010000 A KR 930010000A KR 1019910020103 A KR1019910020103 A KR 1019910020103A KR 910020103 A KR910020103 A KR 910020103A KR 930010000 A KR930010000 A KR 930010000A
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KR
South Korea
Prior art keywords
formula
reacting
pyridine derivative
oxide
base
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Application number
KR1019910020103A
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Korean (ko)
Other versions
KR940005019B1 (en
Inventor
문순구
이관순
길영환
Original Assignee
임성기
한미약품공업 주식회사
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Publication date
Application filed by 임성기, 한미약품공업 주식회사 filed Critical 임성기
Priority to KR1019910020103A priority Critical patent/KR940005019B1/en
Publication of KR930010000A publication Critical patent/KR930010000A/en
Application granted granted Critical
Publication of KR940005019B1 publication Critical patent/KR940005019B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Abstract

본 발명은 다음 구조식(I)로 표시되는 피리딘 유도체의 새로운 제조 방법에 관한 것으로서, 구체적으로는 구조식(Ⅲ)의 3,5-디메틸피리딘-N-옥사이드를 할로겐화제와 반응시켜 일반식(V)의 3,5-디메틸-4-할로피리딘-N-옥사이즈를 제조하고 이를 염기와 반응시키는 것을 특징으로 하는데, 이와 같이 제조된 구조식(I)의 화합물은, 항궤양제로 유용한 오메프라졸(omeprazole)의 제조에 유용하게 사용될 수 있다.The present invention relates to a novel process for preparing a pyridine derivative represented by the following formula (I), specifically, by reacting a 3,5-dimethylpyridine-N-oxide of formula (III) with a halogenating agent (V) To prepare a 3,5-dimethyl-4-halopyridine-N-oxsize of reacting with a base, the compound of formula (I) thus prepared is, of the omeprazole useful as an anti-ulcer agent (omeprazole) It can be usefully used for manufacturing.

[상기 식에서, X는 클로로 또는 브로모이다][Wherein X is chloro or bromo]

Description

피리딘 유도체의 제조방법Method for preparing pyridine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

구조식(Ⅲ)의 3,5-디메틸피리딘-N-옥사이드를 할로겐화제와 반응시켜 일반식(V)의 3,5-디메틸-4-할로피리딘-N-옥사이드를 제조하고 이를 염기와 반응시키는 것을 특징으로 하는 하기 구조식(I)의 3,5-디메틸-4-메톡시피리딘-N-옥사이드의 제조 방법.Reacting 3,5-dimethylpyridine-N-oxide of formula (III) with a halogenating agent to prepare 3,5-dimethyl-4-halopyridine-N-oxide of formula (V) and reacting it with a base A process for producing 3,5-dimethyl-4-methoxypyridine-N-oxide of formula (I) below. [상기 식에서, X는 클로로 또는 브로모이다][Wherein X is chloro or bromo] 제1항에 있어서, 할로겐화제는 다음 일반식(Ⅵ)의 N-할로숙신이미드임을 특징으로 하는 방법.The method according to claim 1, wherein the halogenating agent is N-halosuccinimide of the following general formula (VI). [상기 식에서, X는 클로로 또는 브로모이다][Wherein X is chloro or bromo] 제1항에 있어서, 염기는 클라이센(Claisen) 염기임을 특징으로 하는 방법.The method of claim 1 wherein the base is a Claisen base. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910020103A 1991-11-13 1991-11-13 Process and production of pyrimidine derivatives KR940005019B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910020103A KR940005019B1 (en) 1991-11-13 1991-11-13 Process and production of pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910020103A KR940005019B1 (en) 1991-11-13 1991-11-13 Process and production of pyrimidine derivatives

Publications (2)

Publication Number Publication Date
KR930010000A true KR930010000A (en) 1993-06-21
KR940005019B1 KR940005019B1 (en) 1994-06-09

Family

ID=19322710

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910020103A KR940005019B1 (en) 1991-11-13 1991-11-13 Process and production of pyrimidine derivatives

Country Status (1)

Country Link
KR (1) KR940005019B1 (en)

Also Published As

Publication number Publication date
KR940005019B1 (en) 1994-06-09

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