KR930005626A - 헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법 - Google Patents

헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법 Download PDF

Info

Publication number
KR930005626A
KR930005626A KR1019920017539A KR920017539A KR930005626A KR 930005626 A KR930005626 A KR 930005626A KR 1019920017539 A KR1019920017539 A KR 1019920017539A KR 920017539 A KR920017539 A KR 920017539A KR 930005626 A KR930005626 A KR 930005626A
Authority
KR
South Korea
Prior art keywords
hbnf
alkylated
animal
administering
human
Prior art date
Application number
KR1019920017539A
Other languages
English (en)
Inventor
마아크 바커어 조오지프
보오렌 피이터
Original Assignee
알퐁스 아아르 노에
아메리칸 사이아나밋드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알퐁스 아아르 노에, 아메리칸 사이아나밋드 캄파니 filed Critical 알퐁스 아아르 노에
Publication of KR930005626A publication Critical patent/KR930005626A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 헤파린 결합 축색 성장 촉진 인자(HBNF)를 사용하여 내피 세포와 같은 세포의 세포 성장을 억제하는 방법에 관한 것이다.

Description

헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BHK 세포 고 친화력 수용체에로의 bFGF 결합에 대한 HBNF 및 카르복시메틸화 HBNF의 효과, ●-HBNF, ■-카르복시메틸화 HBNF. 가정법은 실시예 5에 서술되어 있다.
제2도는 소 대동맥 내피(ABAE)세포성장에 대한 HBNF 및 카르복시메틸화 HBNF의 효과, 검정법은 실시예 6에 서술되어 있다. 패널 A:ED50=0.04μM로 기초(●) 및 bFGF-자극된 lng/ml)(▲)ABAE 세포성장을 억제한다. 패널 B:0.33μmM HBNF는 ABAE 세포의 분리를 야기한다. 부융합성 ABAE 세포를, 세포의 가시적인 분리가 일어나는 중에, 4일 동안 0.33μM HBNF에 노출시킨다. “출발”-은 HBNF의 첨가전의 평판을 언급한다. “대조표준”-은 HBNF로 처리하지 않은 평판을 언급하고, “HBNF”-는 HBNF로 처리된 평판을 언급한다. 검정을 두번한다. 패널 C:카르복시메틸화 HBNF는, 각각 ED50=0.24μM과 0.13μM로 기초(●) 및 bFGF-저자극(lng/ml)(▲)ABAE 세포 성장을 억제한다.
제3도는 사람 탯줄 내피(HUVE) 세포 성장에 대한 HBNE 효과, ●-배지내 lng/ml bFGF, ▲-배지내 10ng/ml bFGF, 검정법은 실시예 6에 서술되어 있다.

Claims (10)

  1. 헤파린 결합 축색-성장 촉진 인자(HBNF), 알킬화 HBNF, 또는 그이 조합물의 세포성장 억제량을 동물에 투여하는 것을 구성되는 세포 성장을 억제하는 방법.
  2. 제1항에 있어서, 상기 HBNF 또는 알킬화 HBNF는 사람 HBNF, 소 HBNF, 양 HBNF, 개 HBNF, 돼지 HBNF, 고양이 HBNF, 말 HBNF, 조류 HBNF, 어류 HBNF또는 그의 알킬화 동족체인 방법.
  3. HBNF, 알킬화-HBNF, 또는 그의 조합물의 맥환형성-조절량을 상기 동물에 투여하는 것으로 구성되는 동물내에서 맥관 형성을 조절하는 방법.
  4. 제3항에 있어서, 상기 HBNF 또는 알킬화 HBNF는 사람 HBNF, 소 HBNF, 양 HBNF, 돼지 HBNF, 고양이 HBNF, 말 HBNF, 조류 HBNF, 어류 HBNF 또는 그의 알킬화 동족체인 방법.
  5. 반응 세포 검저에서 HBNF를 투여하는 것으로 구성되는 세포 성장 억제제를 생체의 스크리닝 하는 방법.
  6. HBNF, 알킬화 HBNF, 또는 그의 조합물의 외과수술후 출혈 조절양을 온혈 동물에 투여하는 것으로 구성되는 외과수술 후 출혈을 조절하는 방법.
  7. 제6항에 있어서, 상기 HBNF는 사람 HBNF인 방법.
  8. HBNF 단백질, 알킬화 HBNF, 또는 그의 조합물을 동물에 투여하는 것으로 구성되는 종양 성장을 억제하는 방법.
  9. 제8항에 있어서, 상기 HBNF 단백질은 사람 HBNF, 소 HBNF, 양 HBNF, 개 HBNF, 돼지 HBNF, 고양이 HBNF, 말 HBNF, 조류 HBNF, 어류 HBNF 또는 그의 알킬화 동족체인 방법.
  10. 제8항에 있어서, 상기 동물은 사람인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920017539A 1991-09-30 1992-09-25 헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법 KR930005626A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76906391A 1991-09-30 1991-09-30
US07/769,063 1991-09-30

Publications (1)

Publication Number Publication Date
KR930005626A true KR930005626A (ko) 1993-04-20

Family

ID=25084334

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920017539A KR930005626A (ko) 1991-09-30 1992-09-25 헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법

Country Status (7)

Country Link
EP (1) EP0535337A3 (ko)
JP (1) JPH05213771A (ko)
KR (1) KR930005626A (ko)
AU (1) AU648437B2 (ko)
CA (1) CA2079291A1 (ko)
TW (1) TW209172B (ko)
ZA (1) ZA927469B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572851B2 (en) 1997-03-12 2003-06-03 Takashi Muramatsu Method for suppressing or treating drug-induced nephropathy
EP1644027B1 (en) 2003-07-16 2014-04-09 Evotec International GmbH Use of pleiotrophin for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058350T3 (es) * 1988-01-25 1994-11-01 American Cyanamid Co Mitogenos cerebrales de enlace de la heparina.
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence

Also Published As

Publication number Publication date
CA2079291A1 (en) 1993-03-31
JPH05213771A (ja) 1993-08-24
EP0535337A3 (en) 1993-05-19
TW209172B (ko) 1993-07-11
AU2604392A (en) 1993-04-01
ZA927469B (en) 1993-04-13
AU648437B2 (en) 1994-04-21
EP0535337A2 (en) 1993-04-07

Similar Documents

Publication Publication Date Title
Rosa et al. Mesoderm induction in amphibians: the role of TGF-β2-like factors
Cohen The stimulation of epidermal proliferation by a specific protein (EGF)
Asashima et al. Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)
Howes et al. Platelet-derived growth factor enhances demineralized bone matrix-induced cartilage and bone formation
Froesch et al. Nonsuppressible insulin-like activity and thyroid hormones: major pituitary-dependent sulfation factors for chick embryo cartilage.
Chang Hormonal control of molting in decapod Crustacea
Janat et al. Transforming growth factor β1 is a powerful modulator of platelet‐derived growth factor action in vascular smooth muscle cells
Centrella et al. Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.
Maor et al. Insulin-like growth factor I accelerates proliferation and differentiation of cartilage progenitor cells in cultures of neonatal mandibular condyles
KR920702410A (ko) 수정된 생물학적 물질
Yim et al. Cultured oligodendrocytes. A role for cell-substratum interaction in phenotypic expression.
Fukui et al. Identification of activins A, AB, and B and follistatin proteins in Xenopus embryos
MacDonald et al. Upper beak truncation in chicken embryos with the cleft primary palate mutation is due to an epithelial defect in the frontonasal mass
Sagi et al. Spermatogenesis and sperm storage in the testes of the behaviorally distinctive male morphotypes of Macrobrachium rosenbergii (Decapoda, Palaemonidae)
Kusch Predator‐induced morphological changes in Euplotes (Ciliata): Isolation of the inducing substance released from Stenostomum sphagnetorum (turbellaria)
Owen et al. Analysis of the growth factor requirements for stimulation of WI‐38 cells after extended periods of density‐dependent growth arrest
KR930005626A (ko) 헤파린 결합 축색-성장 촉진 인자를 사용하여 세포성장을 억제하는 방법
Flaxman et al. Hormone-independent DNA synthesis by epithelial cells of adult human mammary gland in organ culture
Kato et al. Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats
Dubé et al. Release of metaphase arrest by partial inhibition of protein synthesis in blue mussel oocytes
DE PABLO et al. Insulin-like growth factor-I and insulin as growth and differentiation factors in chicken embryogenesis
Hasebe et al. Rapid and selective removal of larval erythrocytes from systemic circulation during metamorphosis of the bullfrog, Rana catesbeiana
Mikuni-Takagaki et al. Cell-substratum attachment and cell surface hyaluronate of Rous sarcoma virus-transformed chondrocytes.
Hösli et al. Uptake of 3 H-noradrenaline and 3 H-5-hydroxytryptamine in cultured rat brainstem
Tomasovic et al. Relationship between cell survival and heat-stress protein synthesis in a Drosophila cell line

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid