KR920019928A - 향신경성 펩타이드 유도체 - Google Patents

향신경성 펩타이드 유도체 Download PDF

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KR920019928A
KR920019928A KR1019920007128A KR920007128A KR920019928A KR 920019928 A KR920019928 A KR 920019928A KR 1019920007128 A KR1019920007128 A KR 1019920007128A KR 920007128 A KR920007128 A KR 920007128A KR 920019928 A KR920019928 A KR 920019928A
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amino acid
acid sequence
seq
peptide
neuropeptide
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KR1019920007128A
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나오끼 도오도
신이찌로 도조
신이찌 고지마
야스유끼 우에끼
도시오 니시하라
노부유끼 후꾸시마
즈네마사 이리에
게이이찌 오노
히데오 아구이
고세이 오지까
Original Assignee
고세이 오지까
원본미기재
야마모또 마사히꼬
스미또모세이야꾸 가부시끼가이샤
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Application filed by 고세이 오지까, 원본미기재, 야마모또 마사히꼬, 스미또모세이야꾸 가부시끼가이샤 filed Critical 고세이 오지까
Publication of KR920019928A publication Critical patent/KR920019928A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

향신경성 펩타이드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 클론의 검증에 사용하는 올리고뉴클레오타이드의 서열을 나타낸다.
제 2도는 쥐 해마에서 유래한 향신경성 펩타이드 전구체 유전자의 제한 효소 지도 및 뉴클레오타이드 순서를 결정하는 방법을 나타낸다.
제 3도는 제 4도와 함께 쥐 해마에서 유래한 향신경성 펩타이드 전구체 유전자를 함유하는 클론 A61cDNA의 전체 뉴클레오타이드 서열을 나타낸다.

Claims (11)

  1. 하기의 아미노산 서열(서열 제17번)으로 나타내는 향신경성 펩타이드를 코딩하는 유전자.
    Ala Ala Asp Ile Ser Gln Trp Ala Gly Pro Leu
  2. 하기의 아미노산 서열(서열 제15번)으로 나타내는 향신경성 펩타이드를 포함하는 유전자.
    Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu
  3. 하기의 아미노산 서열(서열 제3번)으로 나타내는 폴리펩타이드를 코딩하는 유전자.
    (상기 식에서, X는 Glu 또는 Lys를 나타낸다.)
  4. 하기 아미노산 서열(서열 제14번)으로 나타내는 폴리펩타이드를 코딩하는 유전자.
  5. 제 2항에 따르는 아미노산 서열(서열 제15번)을 갖는 향신경성 펩타이드, 또는 적어도 -Lys-Trp-서열을 갖는 아미노산 서열 부분을 포함하는 향신경 활성을 갖는 향신경성 펩타이드 유도체.
  6. 제 5항에 있어서, N-말단 및/또는 C-말단이 변형된 향신경성 활성을 갖는 향신경성 펩타이드 유도체.
  7. 아미노산 서열(서열 제3번)로 나타내는 향신경성 펩타이드의 전구체 폴리펩타이드.
  8. 아미노산 서열(서열 제14번)로 나타내는 향신경성 펩타이드의 전구체 폴리펩타이드.
  9. 제 3항에 기재된 유전자를 함유하는 재조합 발현 벡터로 형질전환된 세균, 효모 또는 포유동물 세포.
  10. 제 4항에 기재된 유전자를 함유하는 재조합 발현 벡터로 형질전환된 세균, 효모 또는 포유동물 세포.
  11. 제 5항 또는 6항에 기재된 향신경성 펩타이드 또는 향신경성 펩타이드 유도체를 활성 성분으로 포함하는 신경 변경 질환의 치료용 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920007128A 1991-04-27 1992-04-27 향신경성 펩타이드 유도체 KR920019928A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP91-124688 1991-04-27
JP12468891 1991-04-27

Publications (1)

Publication Number Publication Date
KR920019928A true KR920019928A (ko) 1992-11-20

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ID=14891623

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Application Number Title Priority Date Filing Date
KR1019920007128A KR920019928A (ko) 1991-04-27 1992-04-27 향신경성 펩타이드 유도체

Country Status (6)

Country Link
EP (1) EP0511816B1 (ko)
JP (1) JPH05268966A (ko)
KR (1) KR920019928A (ko)
AT (1) ATE182361T1 (ko)
CA (1) CA2067039A1 (ko)
DE (1) DE69229613T2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08504581A (ja) * 1992-12-15 1996-05-21 イエダ リサーチ アンド デベロツプメント カンパニー リミテツド Ｃｐｇ−１神経ポリペプチドをコードするｄｎａ配列およびそれにコードされるポリペプチド
EP0628631A1 (en) * 1993-06-08 1994-12-14 Ono Pharmaceutical Co., Ltd. A phosphatidylethanolamine binding protein derived from a human glioblastoma cell line and DNA encoding it
AU2178000A (en) * 1998-12-11 2000-06-26 Salk Institute For Biological Studies, The Co-factors for trophic factors, and methods of use thereof
WO2005079831A1 (en) * 2004-02-13 2005-09-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of hcnp peptides for the modulation of cardio-vascular physiology and diuresis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ233071A (en) * 1989-03-30 1993-02-25 Sumitomo Pharma Neurotrophic peptides, extraction from mammalian hippocampal tissue and pharmaceutical compositions thereof

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Publication number Publication date
JPH05268966A (ja) 1993-10-19
DE69229613T2 (de) 2000-04-13
ATE182361T1 (de) 1999-08-15
EP0511816B1 (en) 1999-07-21
EP0511816A2 (en) 1992-11-04
CA2067039A1 (en) 1992-10-28
DE69229613D1 (de) 1999-08-26
EP0511816A3 (en) 1993-05-19

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