KR920012087A - Method for preparing benzoxazine derivatives - Google Patents

Method for preparing benzoxazine derivatives Download PDF

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Publication number
KR920012087A
KR920012087A KR1019900022050A KR900022050A KR920012087A KR 920012087 A KR920012087 A KR 920012087A KR 1019900022050 A KR1019900022050 A KR 1019900022050A KR 900022050 A KR900022050 A KR 900022050A KR 920012087 A KR920012087 A KR 920012087A
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South Korea
Prior art keywords
general formula
following general
represented
amino group
organic solvent
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KR1019900022050A
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Korean (ko)
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김찬우
박상후
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하기주
주식회사 코오롱
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Priority to KR1019900022050A priority Critical patent/KR920012087A/en
Publication of KR920012087A publication Critical patent/KR920012087A/en

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

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Description

벤즈옥사진 유도체의 제조방법Method for preparing benzoxazine derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음 일반식(VII)로 표시되는 에틸-2,3,4,5-테트라할로 벤조일 아세테이트와 다음 일반식(VI)로 표시되는 아민화합물을 반응시켜서 다음 일반식(V)로 표시되는 4-위치에 아미노기로 치환된 에틸2,3,5-트리할로벤조일 아세테이트를 제조한후, 디메틸포름아미드디메틸아세틸과 가음 일반식(IV)로 표시되는 2-아미노-1-알칸올과의 반응혼합물과 반응시켜서 다음 일반식(III)으로 표시되는 화합물을 제조한 후, 극성유기 용매하에서 금속염과 반응시켜서 다음 일반식(II)로 표시되는 화합물을 제조후 이를 가수분해시킴을 특징으로 하는 다음 일반식(I)로 표시되는 벤즈옥사진 유도체를 제조하는 방법.4- represented by the following general formula (V) by reacting ethyl-2,3,4,5-tetrahalo benzoyl acetate represented by the following general formula (VII) with an amine compound represented by the following general formula (VI) After preparing ethyl 2,3,5-trihalobenzoyl acetate substituted with an amino group at the position, a reaction mixture of dimethylformamide dimethylacetyl and 2-amino-1-alkanol represented by the general formula (IV) To a compound represented by the following general formula (III), and then reacted with a metal salt in a polar organic solvent to prepare a compound represented by the following general formula (II) and then hydrolyze it. A method for producing a benzoxazine derivative represented by (I). 상기 식에서, X는 할로겐 원자를 나타내고, R은 수소원자 또는 탄소수 1-6의 알킬기를 나타내며, A는 단일치환된 아미노기, 이 치환된 아미노기는 또다른 헤테로원자를 함유하는 환상의 아미노기를 나타낼 수 있으며, Et는 에틸기를 나타낸다.Wherein X represents a halogen atom, R represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, A represents a monosubstituted amino group, and this substituted amino group may represent a cyclic amino group containing another hetero atom, And Et represent an ethyl group. 제1항에서 극성용매로 디메틸술폭시드, 디메틸포롬아미드, 디메틸아세트아미드, 아세토니트릴 및 물에서 선택된 용매 또는 이들 용매의 혼합물을 사용하는 방법.The method of using a solvent selected from dimethyl sulfoxide, dimethyl formomamide, dimethyl acetamide, acetonitrile and water as a polar solvent or a mixture of these solvents. 제1항에서 유기용매로 디메틸술폭시드, 디메틸프롬아미드, 디옥산에서 선택된 유기용매를 사용하는 방법.The method of using an organic solvent selected from dimethyl sulfoxide, dimethylformamide, dioxane as the organic solvent in claim 1. 제1항에서 금속염으로 소듐 하이드라이드 또는 칼륨하이드라이드를 사용하는 방법.The method of using sodium hydride or potassium hydride as the metal salt in claim 1. ※ 참고사항: 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019900022050A 1990-12-27 1990-12-27 Method for preparing benzoxazine derivatives KR920012087A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900022050A KR920012087A (en) 1990-12-27 1990-12-27 Method for preparing benzoxazine derivatives

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KR1019900022050A KR920012087A (en) 1990-12-27 1990-12-27 Method for preparing benzoxazine derivatives

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KR920012087A true KR920012087A (en) 1992-07-25

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100494882B1 (en) * 1999-08-21 2005-06-14 경동제약 주식회사 A process for preparing (-)-9-Fluoro-2,3-dihydro-3(S)-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
KR100494881B1 (en) * 1999-08-21 2005-06-14 경동제약 주식회사 Ethyl 2-[2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)]benzoyl-3(S)-(1-hydroxyprop-2-ylamino)acrylate and a process for preparing thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100494882B1 (en) * 1999-08-21 2005-06-14 경동제약 주식회사 A process for preparing (-)-9-Fluoro-2,3-dihydro-3(S)-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
KR100494881B1 (en) * 1999-08-21 2005-06-14 경동제약 주식회사 Ethyl 2-[2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)]benzoyl-3(S)-(1-hydroxyprop-2-ylamino)acrylate and a process for preparing thereof

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