KR920004351A - Novel quinolone carboxylic acid derivatives and preparation method thereof - Google Patents

Novel quinolone carboxylic acid derivatives and preparation method thereof Download PDF

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Publication number
KR920004351A
KR920004351A KR1019900012624A KR900012624A KR920004351A KR 920004351 A KR920004351 A KR 920004351A KR 1019900012624 A KR1019900012624 A KR 1019900012624A KR 900012624 A KR900012624 A KR 900012624A KR 920004351 A KR920004351 A KR 920004351A
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South Korea
Prior art keywords
carboxylic acid
quinolone carboxylic
acid derivative
halogen element
nitrogen
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KR1019900012624A
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Korean (ko)
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KR920006780B1 (en
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권한택
정점양
김두언
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한승수
제일약품 주식회사
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Priority to KR1019900012624A priority Critical patent/KR920006780B1/en
Publication of KR920004351A publication Critical patent/KR920004351A/en
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Publication of KR920006780B1 publication Critical patent/KR920006780B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

신규한 퀴놀론 카르복실산유도체와 그 제조방법Novel quinolone carboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

다음 구조식(Ⅰ)로 표시되는 신규한 퀴놀론 카복실산유도체 및 그 염.The novel quinolone carboxylic acid derivative represented by the following structural formula (I) and its salt. 상기식에서, R1은 디아미노페닐기이고, R2는 할로겐원소 또는 질소를 함유하는 헤테로싸이크릭화합물을 나타낸다.Wherein R 1 is a diaminophenyl group, and R 2 represents a heterocyclic compound containing a halogen element or nitrogen. 제1항에 있어서, 상기 R1은 2, 4-디아미노페닐기인 것을 특징으로 하는 퀴놀론 카르복실산유도체.The quinolone carboxylic acid derivative according to claim 1, wherein R 1 is a 2,4-diaminophenyl group. 제1항에 있어서 상기 R2는 염소원자 또는 모포린, 치오모포린, 피페라진 및 N-메칠피레라진기 중에서 선택된 것임을 특징으로 하는 퀴놀론 카르복실산유도체.The quinolone carboxylic acid derivative according to claim 1, wherein R 2 is selected from a chlorine atom or a morpholine, chimorphorin, piperazine and N-methylpyreazine. 다음구조식(Ⅱ)로 표시되는 6-플루오로-7-할로-1,4-디하이드로-4-옥소-3-퀴놀린 카복실산 에틸에스테르에 디니트로 클로로벤젠과 탄산칼륨을 DMF용매하에 반응시켜서 다음구조식(Ⅲ)의 화합물을 제조한후, 이를 산성조건에서 철 또는 주석을 사용하여 환원시켜서 다음구조식(Ⅰ)로 표시되는 퀴놀론 카복실산유도체를 제조하는 방법.6-fluoro-7-halo-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester represented by the following formula (II) was reacted with dinitro chlorobenzene and potassium carbonate in a DMF solvent. A method of preparing the quinolone carboxylic acid derivative represented by the following structural formula (I) by preparing the compound of (III) and then reducing it with iron or tin under acidic conditions. 상기식에서, X는 할로겐 원소이며, R1은 디아미노페닐기이고, R2는 할로겐원소 또는 질소를 함유하는 헤테로싸이크릭화합물이고, R3는 디니트로페틸기를 나타낸다.Wherein X is a halogen element, R 1 is a diaminophenyl group, R 2 is a heterocyclic compound containing a halogen element or nitrogen, and R 3 represents a dinitropetyl group. 다음구조식(Ⅰ)로 표시되는 퀴놀론 카복실산유도체를 유효성분으로 하는 항균활성을 갖는 약제조성물.A pharmaceutical composition having an antimicrobial activity comprising a quinolone carboxylic acid derivative represented by the following structural formula (I) as an active ingredient. 상기식에서, R1은 디아미노페닐기이고, R2는 할로겐원소 또는 질소를 함유하는 헤테로싸이크릭화합물을 나타낸다.Wherein R 1 is a diaminophenyl group, and R 2 represents a heterocyclic compound containing a halogen element or nitrogen. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019900012624A 1990-08-16 1990-08-16 Quinolnone carboxcylic acid derivatives KR920006780B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900012624A KR920006780B1 (en) 1990-08-16 1990-08-16 Quinolnone carboxcylic acid derivatives

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Application Number Priority Date Filing Date Title
KR1019900012624A KR920006780B1 (en) 1990-08-16 1990-08-16 Quinolnone carboxcylic acid derivatives

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KR920004351A true KR920004351A (en) 1992-03-27
KR920006780B1 KR920006780B1 (en) 1992-08-17

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100589429B1 (en) * 2004-08-31 2006-06-14 한국화학연구원 Process for preparation of quinolone derivatives substituted by aminopyridyl moieties at n-1 site
KR101876558B1 (en) * 2011-12-08 2018-07-10 엘지디스플레이 주식회사 2-Dimensional and 3-Dimensional Display Device without glasses

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