KR910015302A - Compositions for Continuous Release of Polypeptides Having In Vivo Activity - Google Patents

Compositions for Continuous Release of Polypeptides Having In Vivo Activity Download PDF

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Publication number
KR910015302A
KR910015302A KR1019900001689A KR900001689A KR910015302A KR 910015302 A KR910015302 A KR 910015302A KR 1019900001689 A KR1019900001689 A KR 1019900001689A KR 900001689 A KR900001689 A KR 900001689A KR 910015302 A KR910015302 A KR 910015302A
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KR
South Korea
Prior art keywords
composition
growth hormone
polypeptide
vivo activity
tocopherol
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Application number
KR1019900001689A
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Korean (ko)
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KR920005688B1 (en
Inventor
김남중
이병건
Original Assignee
최근선
주식회사 럭키
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Application filed by 최근선, 주식회사 럭키 filed Critical 최근선
Priority to KR1019900001689A priority Critical patent/KR920005688B1/en
Priority to AU70937/91A priority patent/AU653325B2/en
Priority to NZ237084A priority patent/NZ237084A/en
Priority to JP3041336A priority patent/JP2620417B2/en
Publication of KR910015302A publication Critical patent/KR910015302A/en
Application granted granted Critical
Publication of KR920005688B1 publication Critical patent/KR920005688B1/en
Priority to US08/275,329 priority patent/US5520927A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음No content

Description

생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물Compositions for Continuous Release of Polypeptides Having In Vivo Activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제 1도는 표 1에 따른 그래프, 제 2도는 표 2에 따른 그래프.1 is a graph according to Table 1, 2 is a graph according to Table 2.

Claims (7)

초산토코페롤 또는 토코페롤 및 그의 유도체로 구성된 군에서 선택된 1종 또는 2종이상의 물질과 지연 보조제로 이루어진 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.A composition for continuously releasing a polypeptide having in vivo activity, characterized in that it comprises one or more substances selected from the group consisting of tocopherol acetate or tocopherol and derivatives thereof and a delayed adjuvant. 제1항에 있어서, 상기 지연보조제는 알루미늄 모노스테아레이트, 칼슘 스테아레이트, 밀랍, 카르나우바왁스 또는 파라핀인 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.The composition of claim 1, wherein the delayed adjuvant is aluminum monostearate, calcium stearate, beeswax, carnauba wax or paraffin. 제1항에 있어서, 상기 초산토코페롤 또는 토코페롤 및 그 유도체는 조성물 전체중량에 대하여 95 내지 98중량%사용되는 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.The composition of claim 1, wherein the tocopherol acetate or tocopherol and its derivatives are used in an amount of 95 to 98% by weight based on the total weight of the composition. 제1항 또는 제2항에 있어서, 상기 지연보조제는 조성물 전체중량에 대하여 2 내지 5중량%사용되는 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.The composition of claim 1 or 2, wherein the retardation aid is used in an amount of 2 to 5% by weight based on the total weight of the composition. 제1항에 있어서, 상기 폴리펩티드는 동물 성장호르몬, 인간 성장호르몬 및 인슐린, 인터페론, 인터루킨-Ⅱ, 종양괴사인자, 콜로니자극인자 및 그 유사체로 이루어진 군에서 선택된 1종의 폴리펩티드인 것을 특징으로 하는 생체내 활성을 갖는폴리펩티드를 지속적으로 방출시키는 조성물.According to claim 1, wherein the polypeptide is a living growth hormone, human growth hormone and a living body, characterized in that one polypeptide selected from the group consisting of insulin, interferon, interleukin-II, tumor necrosis factor, colony stimulating factor and the like A composition that continuously releases a polypeptide having resistance to activity. 제5항에 있어서, 상기 동물 성장호르몬은 착이온 금속을 부착시키지 않은 것이거나 또는 착이온 금속을 부착시킨 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.6. The composition of claim 5, wherein said animal growth hormone does not have a complex ion metal attached thereto or has a complex metal attached thereto. 제5항 또는 제6항에 있어서, 상기 동물 성장호르몬은 우형소마토트로핀, 돼지 성장호르몬, 산양 및 면양 성장호르몬, 가금 성장호르몬, 연어 성장호르몬 또는 어패류 성장호르몬인 것을 특징으로 하는 생체내 활성을 갖는 폴리펩티드를 지속적으로 방출시키는 조성물.In vivo activity according to claim 5 or 6, wherein the animal growth hormone is bovine bovine matotropin, pig growth hormone, goat and sheep growth hormone, poultry growth hormone, salmon growth hormone or shellfish growth hormone A composition for sustaining release of a polypeptide having a. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900001689A 1990-02-12 1990-02-12 Composition of polypeptide which releasing continously KR920005688B1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019900001689A KR920005688B1 (en) 1990-02-12 1990-02-12 Composition of polypeptide which releasing continously
AU70937/91A AU653325B2 (en) 1990-02-12 1991-02-11 A composition durably releasing bioactive polypeptides
NZ237084A NZ237084A (en) 1990-02-12 1991-02-11 Composition for the prolonged release of somatotropin comprising the somatotropin, a tocopherol component, and an assistant delaying agent
JP3041336A JP2620417B2 (en) 1990-02-12 1991-02-12 Compositions for sustained release of biologically active polypeptides
US08/275,329 US5520927A (en) 1990-02-12 1994-07-14 Method for the preparation of sustained release somatotropin and product produced thereby

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900001689A KR920005688B1 (en) 1990-02-12 1990-02-12 Composition of polypeptide which releasing continously

Publications (2)

Publication Number Publication Date
KR910015302A true KR910015302A (en) 1991-09-30
KR920005688B1 KR920005688B1 (en) 1992-07-13

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KR1019900001689A KR920005688B1 (en) 1990-02-12 1990-02-12 Composition of polypeptide which releasing continously

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KR920005688B1 (en) 1992-07-13

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