KR910006273A - New 1,4-dihydro-4-oxoquinoline derivatives - Google Patents

New 1,4-dihydro-4-oxoquinoline derivatives Download PDF

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KR910006273A
KR910006273A KR1019890013698A KR890013698A KR910006273A KR 910006273 A KR910006273 A KR 910006273A KR 1019890013698 A KR1019890013698 A KR 1019890013698A KR 890013698 A KR890013698 A KR 890013698A KR 910006273 A KR910006273 A KR 910006273A
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South Korea
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tetrahydro
dihydro
oxo
difluoro
quinolinecarboxylic acid
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KR1019890013698A
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Korean (ko)
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KR930000924B1 (en
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김충섭
채정석
이태오
김재규
신양철
강희일
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연만희
주식회사 유한양행
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

신규 1,4-디히드로-4-옥소퀴놀린 유도체New 1,4-dihydro-4-oxoquinoline derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (14)

항생물질로 유용한 일반식(I)의 화합물 및 그것의 제약학적으로 허용가능한 산부가 또는 염기염.Compounds of formula (I) and pharmaceutically acceptable acid addition or base salts thereof useful as antibiotics. 상기 일반식(I)에서 R1은 탄소수 1~4의 저급알킬, 2-플루오로에틸, 시클로프로필, 4-플루오로페닐 또는 2,4-디플루오로페닐이고, R2는 1,2,3,4-테트라히드로-2-이소퀴놀린일, 1,2,3,4-테트라히드로-7-아미노-2-이소퀴놀린일, 1,2,3,4-테트라히드로-7-메틸아미노-2-이소퀴놀린일,5,6,7,8-테트라히드로-1,6-일, 5,6,7,8-테트라히드로-1,7-나프티리딘-7-일, 1,2,3,4-테트라히드로-2-6-나프티리딘-2-일, 1,2,3,4-테트라히드로-2,7-나프티리딘-2-일 또는 2-이소인돌린일이며, X1은 수소, 플루오로 클로로 또는 메톡시이고, X2는 수소 또는 아미노이다.In general formula (I), R 1 is lower alkyl, 2-fluoroethyl, cyclopropyl, 4-fluorophenyl or 2,4-difluorophenyl having 1 to 4 carbon atoms, and R 2 is 1,2, 3,4-tetrahydro-2-isoquinolinyl, 1,2,3,4-tetrahydro-7-amino-2-isoquinolinyl, 1,2,3,4-tetrahydro-7-methylamino- 2-isoquinolinyl, 5,6,7,8-tetrahydro-1,6-yl, 5,6,7,8-tetrahydro-1,7-naphthyridin-7-yl, 1,2,3 , 4-tetrahydro-2-6-naphthyridin-2-yl, 1,2,3,4-tetrahydro-2,7-naphthyridin-2-yl or 2-isoindolinyl, X 1 is Hydrogen, fluoro chloro or methoxy and X 2 is hydrogen or amino. 제1항에서 1-에틸-7-(1,2,3,4-테트라히드로-2-이소퀴놀린일)-6-플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-ethyl-7- (1,2,3,4-tetrahydro-2-isoquinolinyl) -6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxyl according to claim 1 mountain. 제1항에서 1-시클로프로필-7-(1,2,3,4-테트라히드로-2-이소퀴놀린일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-7- (1,2,3,4-tetrahydro-2-isoquinolinyl) -6,8-difluoro-1,4-dihydro-4-oxo-3 in claim 1 Quinolinecarboxylic acid. 제1항에서 1-시클로프로필-7-(1,2,3,4-테트라히드로-7-아미노-2-이소퀴놀린일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-7- (1,2,3,4-tetrahydro-7-amino-2-isoquinolinyl) -6,8-difluoro-1,4-dihydro-4 in claim 1 Oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로프로필-5-아미노-7-(1,2,3,4-테트라히드로-7-아미노-2-이소퀴놀린일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-5-amino-7- (1,2,3,4-tetrahydro-7-amino-2-isoquinolinyl) -6,8-difluoro-1,4- in claim 1 Dihydro-4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-(2,4-디플루오로페닐)-7-(5,6,7,8-테트라히드로-1,6-나프티리딘-6-일)-6-플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1- (2,4-difluorophenyl) -7- (5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl) -6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-(2-플루오로에틸)-7-(5,6,7,8-테트라히드로-1,6-나프티리딘-6-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1- (2-fluoroethyl) -7- (5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl) -6,8-difluoro-1 in claim 1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-(3급부틸)-7-(5,6,7,8-테트라히드로-1,6-나프티리딘-6-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1- (tertbutyl) -7- (5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl) -6,8-difluoro-1,4- in claim 1 Dihydro-4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로포로필-7-(5,6,7,8-테트라히드로-1,6-나프티리딘-6-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cycloporophyl-7- (5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl) -6,8-difluoro-1,4-dihydro in claim 1 4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로프로필-5-아미노-7-(5,6,7,8-테트라히드로-1,6-나프티리딘-6-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-5-amino-7- (5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl) -6,8-difluoro-1,4 in claim 1 -Dihydro-4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로프로필-7-(5,6,7,8-테트라히드로-1,7-나프티리딘-7-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-7- (5,6,7,8-tetrahydro-1,7-naphthyridin-7-yl) -6,8-difluoro-1,4-dihydro- in claim 1 4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로프로필-7-(1,2,3,4-테트라히드로-2,6-나프티리딘-2-일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-7- (1,2,3,4-tetrahydro-2,6-naphthyridin-2-yl) -6,8-difluoro-1,4-dihydro- in claim 1. 4-oxo-3-quinolinecarboxylic acid. 제1항에서 1-시클로프로필-7-(2-이소인돌린일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산.1-cyclopropyl-7- (2-isoindolinyl) -6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid according to claim 1. 제1항에서 1-시클로프로필-5-아미노-7-(2-이소인돌린일)-6,8-디플루오로-1,4-디히드로-4-옥소-3-퀴놀린카르복실산이다.Is 1-cyclopropyl-5-amino-7- (2-isoindolinyl) -6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid . ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890013698A 1989-09-23 1989-09-23 Novel 1,4-dihydro-4-oxoquinoline derivatives KR930000924B1 (en)

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