KR910001919B1 - Anti-bacterial tooth-paste - Google Patents

Abstract

An antibacterial tooth paste is mfd. by adding an antibacterial Robinia pseudo-acacia perfume (A) to the known tooth paste (B) [mixing wt. ratio of A and B is 0.5-1.5:100 . The antibacterial perfume comprises 2-30 parts linalool, 2-30 parts trans-ocimene, 1-5 parts myrcene, 0.5-5 parts trans-alpha-farnesene and 1-5 parts limonene. The tooth paste has a good antibacterial action against streptococcusmutans.

Description

Antimicrobial toothpaste

In the present invention, among the fragrance components of the acacia (Robinia pseudo-acacia, Lin) flower, the fragrance component having a strong bactericidal power against the bacteria causing periodontal disease, particularly called periodontitis or tooth decay, is effectively added to the treated toothpaste to acacia odor. It relates to toothpaste that has a bactericidal or antimicrobial activity against microorganisms in the oral cavity.

Typically, ointment toothpaste is composed of a major component, such as abrasives, moisturizing agents, surfactants, binders, sweeteners, fragrances, antiseptic disinfectants, pigments, stabilizers and the like and other necessary ingredients.

Here, the antiseptic fungicide used in the manufacture of toothpaste among the above ingredients is used to prevent the contents from being separated or deteriorated since the toothpaste product is contaminated by bacteria or mold during production, storage, distribution and use. The antiseptic disinfectant is a cause of tooth decay, periodontal, gingivitis, and acts to sterilize or inhibit the metabolism of the microorganisms in the oral cavity that causes bad breath, as the antiseptic disinfectant parahydroxy benzoate, chloride Phenols, benzoic acid and salts thereof, fluorine compounds, sodium dihydroacetate, strontium chloride and the like are used, and usually two or more thereof are mixed and used.

However, as described above, the antiseptic disinfectants generally used are inactivated by surfactants or abrasives contained in the toothpaste composition, and thus the activity of the preservatives is often lowered, and the antiseptic force is prevented from being lowered or inactivated. Too much antiseptic fungicide may cause irritation of the oral mucosa, causing swelling, blistering or erythema, or central nervous disorders. In the case of fluorine compounds, there are disadvantages of causing spots on teeth.

An object of the present invention is to solve these problems, firstly, acacia flower fragrance extract extracted from acacia flowers recognizes that there is a strong antimicrobial activity against microorganisms, especially Streptococcusmutans sp known as the causative agent of caries By using this properly in toothpaste manufacturing, not only to increase the antiseptic power of the product itself, but also to provide more antiseptic antibacterial toothpaste against oral microorganisms, and secondly, by overdose of preservatives used in the manufacture of toothpaste. To reduce the side effects caused by oral mucosa and human body to minimize the antimicrobial toothpaste to increase the existing antiseptic disinfection power, third, by adding acacia fragrance to the toothpaste using a small amount of antiseptic disinfectant products Excessive of preservatives by enabling the preservation of As well as to minimize side effects caused by hwahal can prevent cavities salt, periodontitis, gingivitis a bactericidal action to the oral microorganisms and to provide an antimicrobial toothpaste cake at the same time prevent bad breath.

The acacia flavoring component used in the present invention is an acacia flavoring component that analyzes the fragrance component from the acacia flowers immediately after flowering and reconstructs the acacia scent to regenerate the acacia fragrance based on the highly bactericidal perfume of each component according to the analysis result. Silver may be embodied as 5 to 30 parts of linalul, 5 to 40 minutes of trans-oxymen, 1 to 5 parts of myricin, 0.5 to 5 parts of trans-alpha-panisine, and 1 to 5 parts of limonene.

And, the acacia flavor component can be analyzed by a number of methods, but in the present invention was analyzed by the following two methods, one of the headspace steam analysis method of specially manufactured acacia blossom immediately after flowering ( The fragrance component released from the flower by the Haea space gas analysis analyzer is continuously circulated and adsorbed on a column packed with activated carbon or Tenax GC of adsorbent 30 to 60 mesh and analyzed by GC / MS. Silver acacia flower was collected by leaching with normal hexane to evaporate the solvent. The acacia concrete coming out was dissolved in alcohol again, cooled to minus 20 ℃ to minus 5 ℃ for about 1 day and filtered Director Absolute is also analyzed by GC / MS.

Each acacia flavor component according to the result of the analysis is efficiently combined and processed to manufacture toothpaste according to a conventional toothpaste manufacturing method.

Here, the acacia fragrance component according to the above analysis result was used to calculate the bactericidal power against general bacteria or periodontal bacteria (Rideal & Walker 1903), the experimental process and results are as follows. After collecting contaminants deposited around the tartar in the oral cavity of a randomly selected adult, dispersed in physiological saline, a small amount was collected and applied to Mitis salivarius medium, and then incubated at 37 ° C. for about 24 hours. After separating the bacteria that form the unique colony of Streptococcus mutans, it is purified again and used as a test bacterium. As a general bacterium, E. Coli ATCC 9637, Staphylococcus aureus ATCC 6538P The coefficient of phenol of the component found to be excellent as a result of the test using was as shown in Table 1.

TABLE 1

As shown in the experimental results of the phenolic acid coefficient of Table 1, the acacia flavor component generally shows a high phenolic acid coefficient for all three test bacteria, especially caries and periodontal than common bacteria E. coli and Staphylococcus aureus. Considering that the test bacteria of Streptococcus mutans, known as disease-causing bacteria, have higher phenolic acid coefficients, the bactericidal power shows higher results.

Here, the "steering acacia" of Table 1 is the acacia flavoring component Linalul (Linalool), trans-oxymene (t-Ocimene), mycin (Myrcene), limonene (Limonene), trans-alpha-panisin (t It is a fragrance ingredient that combines acacia fragrance with -α-farnesene as the main ingredient.

And, in order to find out the antimicrobial activity of the toothpaste flavored with the steering acacia flavoring agent mainly composed of the components of the phenol coefficient test results as follows, the test by the cylinder method as follows.

Samples of toothpaste containing 1.0% of the mixed toothpaste and the akisan flavoring ingredient, which were not prescribed acacia flavoring ingredients, were prepared with 10% diluent solution, and methylpara-hydroxybenzoic acid 0.02 as a control sample. % Solution was used and placed on a cylinder of 8 mm diameter on the agar plate coated with test bacteria solution. The diluted sample was filled into the cylinder, and incubated at about 37 ° C. for 24 hours, and then the size of the inhibitor ring around the cylinder was nonius. ) Was measured squarely and showed the following results.

Table 2, Test Ring Size Test Results

TABLE 2

In view of the above results, when the fragrance using a regeneration combination of acacia fragrance components in the toothpaste, it was shown that even if the amount of preservative disinfectant existing in toothpaste can be reduced, effective antiseptic sterilization power can be maintained.

Hereinafter, the composition of the steering acacia flavoring and the composition of the toothpaste containing the steering acacia flavoring component will be described.

Example 1

Example 2

Example 3

Claims (2)

An antimicrobial toothpaste comprising: 0.5 to 1.5 parts by weight of acacia flavorings, which are mainly composed of antibacterial flavoring ingredients, are added to toothpaste per 100 parts by weight of toothpaste. According to claim 1, wherein the steering acacia medicament mainly composed of antimicrobial fragrance components are linarul 2-30 parts, trans-oxymen 2-30 parts, myricin 1-5 parts, trans-alpha-panisin 0.5-5 Antimicrobial toothpaste, consisting of 1 part and 5 parts limonene.