KR900009659A - New beta-lactam antibiotics and preparation method thereof - Google Patents

New beta-lactam antibiotics and preparation method thereof Download PDF

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Publication number
KR900009659A
KR900009659A KR1019880017627A KR880017627A KR900009659A KR 900009659 A KR900009659 A KR 900009659A KR 1019880017627 A KR1019880017627 A KR 1019880017627A KR 880017627 A KR880017627 A KR 880017627A KR 900009659 A KR900009659 A KR 900009659A
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South Korea
Prior art keywords
coom
hydrogen
formula
preparation
lactam antibiotics
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KR1019880017627A
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Korean (ko)
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KR970004041B1 (en
Inventor
조성기
이상무
김천규
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손영희
제일제당 주식회사
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Priority to KR1019880017627A priority Critical patent/KR970004041B1/en
Publication of KR900009659A publication Critical patent/KR900009659A/en
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Publication of KR970004041B1 publication Critical patent/KR970004041B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

신규한 베타락탐 항생물질 및 이의 제조방법New beta-lactam antibiotics and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

구조식(Ⅰ)로 표시되는 약리학적으로 유용한 화합물Pharmacologically useful compound represented by structural formula (I) 상기 식에서, R1은, 수소, 포르밀 또는 아세틸이고, R2는, 페닐, 4­히드록시페닐이며, A는 ­C(CH3)2CH(COOM)­또는 ­CH2(R3)＝C(COOM)­이고, 여기에서 R3는 아세톡시메틸, 메틸, 클로로, 1­카르복시메틸테트라졸릴티오메틸, M은 수소와 리튬,나트륨, 칼륨을 포함하는 무기양이온이다.Wherein R 1 is hydrogen, formyl or acetyl, R 2 is phenyl, 4 hydroxyphenyl and A is C (CH 3 ) 2 CH (COOM) or CH 2 (R 3 ) = C (COOM Where R 3 is acetoxymethyl, methyl, chloro, 1carboxymethyltetrazolylthiomethyl, and M is an inorganic cation including hydrogen, lithium, sodium and potassium. 구조식(Ⅱ)화합물의 카르복실기에서의 반응성유도체를 구조식(Ⅲ)의 화합물 또는 그 유도체와 반응시켜 구조식(Ⅰ)의 목적화합물을 제조하는 방법.A process for preparing the target compound of formula (I) by reacting a reactive derivative in the carboxyl group of the formula (II) with a compound of formula (III) or a derivative thereof. 상기 식에서, R1은 수소, 포르밀 또는 아세틸이고, R2는 페닐, 4­히드록시페닐이며, A는 ­C(CH3)2CH(COOM)­ 또는 ­CH2(R3)＝C(COOM)-이고, 여기에서 R3는 아세톡시메틸, 메틸, 클로로, 1­카르복시 메틸테트라졸릴티오메틸, M은 수소와 리튬,나트륨, 칼륨을 포함하는 무기양이온이다.Wherein R 1 is hydrogen, formyl or acetyl, R 2 is phenyl, 4 hydroxyphenyl, A is C (CH 3 ) 2 CH (COOM) or CH 2 (R 3 ) = C (COOM)- Wherein R 3 is acetoxymethyl, methyl, chloro, 1carboxy methyltetrazolylthiomethyl, M is hydrogen cation and an inorganic cation including lithium, sodium and potassium. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880017627A 1988-12-28 1988-12-28 Benzothiazine derivatives quinolone KR970004041B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880017627A KR970004041B1 (en) 1988-12-28 1988-12-28 Benzothiazine derivatives quinolone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019880017627A KR970004041B1 (en) 1988-12-28 1988-12-28 Benzothiazine derivatives quinolone

Publications (2)

Publication Number Publication Date
KR900009659A true KR900009659A (en) 1990-07-05
KR970004041B1 KR970004041B1 (en) 1997-03-24

Family

ID=19280749

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880017627A KR970004041B1 (en) 1988-12-28 1988-12-28 Benzothiazine derivatives quinolone

Country Status (1)

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KR (1) KR970004041B1 (en)

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Publication number Publication date
KR970004041B1 (en) 1997-03-24

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