KR900008313B1 - Cosmetic composition contains liposome mixture using non-ionic active agents - Google Patents

Abstract

A liposome mixt.-stabilized compsn. comprises a non-ionic active agent having multi-molecular structure and small quantity of surface tension of oil, a compsn. combined the active agent with polyhydric alcohol, an antiseptic of benzoic acids and a resin as an emulsifying stabilizer. The alcohol is pref. cetostearyl alcohol, and 1.3- butylene glycol or propylene glycol or polyethylene glycol. The stabilized compsn. is useful for moisture milk lotions, and has good skin protecting effects.

Description

Liposome mixture stabilizing composition using a nonionic activator and preparation method thereof

The present invention relates to a cosmetic composition capable of stabilizing a liposome (Liposome) mixture by using an active agent and a method for producing the same, and more particularly to a moisturized milk lotion composition and a method for producing the same.

The present invention is connected to a composition (Application No. 88-15723), that is, a cream phase moisturizing cream composition and a method for preparing the same, which can stabilize the liposome mixture of the present applicant, The composition and the manufacturing method of the moisturizing milk lotion of this invention.

Liposome is mainly lipids (cholesterol, phospholipids) in the configuration and bang the phenomenon that the water (H ₂ O) the phospholipid dispersion having a second medial a structure similar to biological membranes Membrane as natural surface active agent is a lipid second molecular film gehem ( Since its discovery by Bangham, the glomerular material composed of two molecule membranes by this lipid has been called liposomes. Since the composition of liposomes has the property that water-soluble substances exist in the inner aqueous layer and fat-soluble substances exist in lipid double membranes, it is effective to artificially make liposomes such as biological membranes while applying to cosmetics recently. Rapid skin penetration of the ingredients enhances skin protection and treatment.

The cosmetic effect of existing cosmetics simply tried to obtain skin beauty effect by combining skin moisturizing ingredient, skin oil ingredient, skin anti-aging ingredient, and skin whitening ingredient, but these ingredients do not penetrate deep into the skin because they exist mostly as macromolecules. In most cases, the epidermis was extinguished, so there was a problem that the skin beauty effect was lowered.

In addition, in the conventional cosmetics, in order to emulsify or solubilize, an ionic or nonionic surfactant must be used.

Formulation of formulation liposome mixtures with surfactants in these categories did not preserve the liposome mixture stably.

Therefore, the reason why the liposome mixture in these formulations is not stably preserved and destroyed is as follows.

First, in order to form a stable homogeneous emulsion by mixing the oil phase, an ionic or nonionic surfactant should be used, wherein the phospholipid membrane forming liposomes by ED (Ethylene Oxide) is solubilized or forms a mixed layer. The structural film is destroyed.

Second, cholesterol and phospholipids, which are two-molecular structure membranes of liposomes, are biphilic (Amphiphilic) and are easily absorbed and used as an aqueous phase or oil phase, and thus the membrane of liposomes is broken.

Third, since the emulsifier is emulsified using a low hydrophilic lipophilic balance (HLB 價), even if a lipophilic emulsified product is made, it is impossible to preserve the liposomes because the constituent layers of the liposomes move toward the oil component of the continuous phase.

Fourth, the state-of-the-art method used for stabilizing lipoism is also a double emulsifying type (Water In Oil In Water: W / O / W), but a nonionic surfactant must be used.

Fifth, since most oils used in conventional emulsion products (mill lotion) have a large surface tension, in order to stabilize the emulsion, it is necessary to use an ether or ester-based nonionic surfactant with ED. did.

Sixth, any type of emulsifier must be used in order to form an emulsion, but since a surfactant having an anion, a cation, a nonion, an amphoteric ion, etc. was used, it was impossible to mix liposomes.

Seventh, even when the emulsification is prevented by any physical force without using a nonionic surfactant, it can be temporarily formed but not commercialized.

Eighth, gel-free compositions can stabilize liposomes, but because cosmetics deteriorate, they can't supply flexibility and oil to the skin. Can't.

Ninth, conventional emulsification techniques mostly used higher fatty acid material, but this material is a positively active ionic positively lipophilic material that destroys the phospholipid layer forming a double layer when liposomes are blended.

Therefore, the present invention has been devised to improve the above problems, bar encapsulated the active ingredient into liposomes to quickly penetrate the active ingredient deep into the skin to obtain a cosmetic effect, it is applied directly to the skin to the high transdermal of the liposomes Its purpose is to obtain a definite cosmetic effect by using absorbency, and since these liposomes have weaknesses that cannot be formulated in cosmetics using conventional nonionic surfactants, the liposomes can be kept stable without destroying the compounding liposomes. To maximize the cosmetic effect by penetrating the effective cosmetic ingredients into the cosmetics, it is used to stably preserve the liposome compound in cosmetics (moisture mill lotions) that are emulsified or solubilized without using a nonionic surfactant. It is an object of the invention.

As a means for achieving the object of the present invention described above, first, when forming a milk lotion in cosmetics, using a nonionic active agent having a multi-molecular structure without using a nonionic surfactant, ) The non-ionic activator with low hydrophilic lipophilic balance and low hydrophilic lipophilic balance is used, and the HLB value of the nonionic activator used must be 5.0 or less.

At the same time, even when a nonionic activator is mixed, a HLB value of 5.0 or more is not used.

Second, since ED non-ionic surfactants are not used, in order to formulate milk lotion in cosmetics, the oil must have a low surface tension, and do not use any type of ionic active agent. By using together the nonionic activator which has a polyhydric alcohol, and an oil phase and a water phase component, a combination emulsion phase is obtained.

Third, the properties of the milk lotion should not change over time with the temperature change, and should be the same as the pH of the liposome mixture to be formulated in the cosmetic preparation, and do not use higher fats or salts thereof.

fourth, When choosing preservatives, preservatives of benzoic acid are generally selected carefully because they cannot maintain their preservative power. Resin, which is stable to physicochemical changes, is used as an emulsifier.

Hereinafter, embodiments of the present invention will be described in detail.

As used herein, 1. a nonionic active agent is a substance having a multimolecular structure and is a sugar ester prepared from sugars and fatty acids as raw materials.

This sugar ester is called a sugar ester or sucrose ester and the representative structural formula is as follows.

Where R is an alkyl group

Sugar esters that can be used here are those having a HLB value of 5.0 or less, the composition of the ester is as follows.

R: stearic acid, palmitic acid

The active agent at the time of emulsification uses only the above in 2% -25% by weight.

2. Selection of oil phase mainly uses hydrocarbon series. In the case of oil, the one using less interfacial tension is available. Squalane, Totoba Oil, Sassami Oil, Rose Hips Oil, Hot Bar Oil, Shaflower Oil, Meadowfoam Oil, Moon Dog Oil, etc. are used as antioxidants and mixed with 5% -50% Acetic Tocophenol.

3. Emulsion stabilizers or auxiliaries should be used as 0.1% -1.0% of formulated percentages of xanthan gum, carboxy vinyl oromer, and natural high molecular compounds as resins which are stable to thermal changes and are not amide (Amid) bonds.

4. Alcohol selection uses 1-15% of ethanol, cetanol, ceto-stearyl alcohol, oleyl alcohol, etc. in natural alcohol.

At this time, polymethylene glycol (PEG) PEG-6000 in the polyhydric alcohol is mixed with 0.5% -1.0%, and propylene glycol, glycerin, 1.3-butylene glycols, etc. are mixed with 1% -20%.

5. The choice of preservatives includes benzoic acid salts selected by experiments, such as paraoxy benzoic acid methyl, paraoxy benzoic acid propyl, and high ethylene diamine tetraacetate.

Their amount is used as a weight percentage of 0.1% -0.5%, and methyl-paraoxy benzoic acid propyl-chloro-hexydine-dihydroacetic acid uses a compounding amount of 0.1% -0.4%.

6. The fragrance is used in the highest range that can cover the base odor because the fragrance is present in the continuous phase in the emulsion phase. The fragrance is an organic solvent, and the lipid layer is in contact with the phospholipid layer of the liposome and dispersant in the continuous phase. Since it can be destroyed because it forms a solubilization or mixture, the perfume is added to the oil phase to dissolve uniformly so that it is present in the dispersed phase in the emulsion phase.

As a fragrance | flavor combination of this fragrance, a compounding quantity is 0.1%-0.2%.

As a cosmetic preparation example of the present invention, the result of combining the formulation of the moisturizing milk lotion (liquid phase) and the liposome mixture is demonstrated safety and measurement of skin beauty effect.

The component ratios for the example of the moisturizer milk lotion (milk phase) are as follows.

In the preparation method of the above example, tocophenol acetate 1.0%, squalane 10.0%, totoba oil 10.0%, set-stearyl alcohol 1.5%, sugar fatty acid ester 3.0%, oleyl alcohol 5.0%, capric / caprylic triglyceride 3.0%, Igopropyl myristate 1.0% were dissolved by heating and uniformly mixed, and propylene glycol 8.0%, 1.3 butylene glycol 2.0%, triethanolamine 0.03%, xanthan gum 0.3%, purified water 49.17%, a suitable amount of preservatives by heating After homogenization, the propylene glycol component to the preservative component is added to the propyl acetate component and the propyl glycolate component to emulsify for a certain period of time, followed by cooling and mixing the perfume amount and the liposome mixture (skin moisturizing component) to room temperature. By cooling, an oily moisturizing milk lotion is formed.

(Confirmation of liposomes)

The presence or absence of liposomes according to the above example (milk lotion) was measured by using a measuring instrument: a freeze-cut electron microscope.

As a result, Photo 1 clearly shows that a large amount of liposomes having a composite double membrane is present according to the embodiment of the present invention.

On the other hand, Photo 2, as a conventional embodiment, can not find a composite double membrane and is a phenomenon that is widely spread and destroyed, so that the liposome material cannot be identified.

Therefore, the measurement results of the two samples can confirm that the liposome does not exist in the conventional example using a non-ionic surfactant, it is proved that the liposome glomeruli of the composite double membrane in the embodiment according to the present invention.

(Measure elasticity to skin)

This measurement experiment is an experiment on the living body for a product in which liposomes are alive and liposomes, and the effect according to the examples according to the present invention and the examples according to the present invention.

The experimental device was a skin elasticity measuring device, and the test subjects were 22 females with an average age of 51 years. For the crime prevention, the milk cream was used twice a day for 1 week, 2 weeks, and 3 weeks. While doing so, the milk lotion according to the embodiment of the present invention was divided into eleven people and the milk lotion according to the conventional example was divided into the remaining eleven people.

This The experimental value of the invention is as follows.

T _l : After 1 week

T ₂ : After 2 weeks

T ₃ : After 3 weeks

Experimental value according to the conventional embodiment for this is as follows.

T ₁ : After 1 week

T ₂ : After 2 weeks

T ₃ : After 3 weeks

T ₀ : Before use

The comparison chart for the improvement effect by such experiment is as follows.

As described above, the milk lotion of the present invention, which is prepared according to the examples of the present invention and the conventional example, is applied to the female life, and measured and compared, respectively. Skin elasticity effect is very excellent.

Claims (7)

In a composition capable of stabilizing a liposome mixture, the milk lotion in the cosmetic composition is a combination of an aqueous phase and an oil phase by using a non-ionic active agent having a multi-molecular structure and a low surface tension of oil and a polyhydric alcohol to the active agent A liposome mixture stabilizing composition using a nonionic activator comprising a composition, a preservative of benzoic acid and a lysine (Resin) as an emulsion stabilizer. The polyhydric alcohol according to claim 1, wherein the polyhydric alcohol is ceto-stearyl alcohol, 1,3 butylene glycol, propylene glycol, polyethylene glycol, and has a degree of polymerization of 6300, and the content of 0.1% to 5.0% of cyl alcohol, nontenyl alcohol, and the like. Liposome mixture stabilizing composition using a nonionic activator, characterized in that. The liposome mixture according to claim 1 or 2, wherein xanthan gum and carboxy vinyl polymer are used as superposition agents dissolved in the water phase, and they contain 0.2% -1.0% by weight. Stabilizing composition. The method of claim 1, wherein the studying stabilizer or auxiliaries are stable to thermal changes and are used as non-amide bond resins such as xanthan gum, carboxy vinyl polymer, and natural polymer compounds, which contain 0.1% -1.0%. A liposome mixture using a nonionic activator. 2. The liposome mixture stabilizing composition according to claim 1, wherein the preservative comprises paraoxybenzoic acid methyl, propyl, and sodium ethylene diamine tetra acetate. The oil of the emulsifier stabilizer is a natural vegetable oil, 1.0% -50.0% of macadamia nut oil, cesami oil, totoba oil, rosehips oil, saflower flower oil, meadowfoam oil, moonflower colostrum, etc. Liposome mixture stabilizing composition using a nonionic activator, characterized in that the amount of oil. In the method for preparing a composition (milk lotion) capable of stabilizing the liposome mixture, 1.0% tocophenol acetate, 10.0% squalane, 10.0% totoba oil, 1.5% set-stearyl alcohol, 3.0% sugar fatty acid ester, oleyl alcohol 5.0%, Capric / Caprylic Triglyceride 3.0%, Isopropyl Myristate 1.0% are dissolved by heating and uniformly mixed, Propylene Glycol 8.0%, 1.3 Butylene Glycol 2.0%, Triethanol Amine 0.03%, 0.3% xanthan gum, 49.17% of purified water, homogenized by heating a preservative appropriate amount, and then emulsified by adding the propylene glycol component to the preservative component to the propyl propyl state from the tocophenol acetate component and cooling it for a certain period of time, and then flavoring the perfume Method for preparing a liposome mixture stabilizing composition using a non-ionic activator, characterized in that the mixture is mixed with the liposome mixture and cooled to room temperature. [Photo 1]

[Photo 2]

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