KR900007832A - (1H-azol-1-ylmethyl) substituted quinoline quinazolin or quinoxaline derivatives - Google Patents

(1H-azol-1-ylmethyl) substituted quinoline quinazolin or quinoxaline derivatives Download PDF

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KR900007832A
KR900007832A KR1019890017783A KR890017783A KR900007832A KR 900007832 A KR900007832 A KR 900007832A KR 1019890017783 A KR1019890017783 A KR 1019890017783A KR 890017783 A KR890017783 A KR 890017783A KR 900007832 A KR900007832 A KR 900007832A
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alkyl
hydrogen
amino
mono
alkyloxy
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KR1019890017783A
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KR0149162B1 (en
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제인 에드 가아드 프레인 에디이
가스톤 베네트 마아크
헤르만 마아가레사 레이메케르스 알폰스
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구스타프 반 리이트
쟈안센 파아마슈우티카 엔. 부이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

(1H-아졸-1-일메틸)치환된 퀴놀린, 퀴나졸린 또는 퀴녹살린 유도체(1H-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

일반식의 화합물, 그 산부가염 및 그 입체 이성체.Compounds of the general formula, acid addition salts thereof and stereoisomers thereof. 위의 일반식에서In the formula above -X1=X2는 -CH=CH- (X), -CH=N- (Y) 또는 -N=CH- (Z)이고, R은 수소 또는 C1-6알킬이고, Y는 수소, C1-10알킬, C3-7시클로알킬, Ar',Ar2-C1-6알킬, C2-C6알케닐 또는 C2-6알키닐이고, Z는-X 1 = X 2 is -CH = CH- (X), -CH = N- (Y) or -N = CH- (Z), R is hydrogen or C 1-6 alkyl, Y is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, Ar ', Ar 2 -C 1-6 alkyl, C 2 -C 6 alkenyl or C 2-6 alkynyl, Z is R1,R4및 R10은 각각 수소, C1-6알킬 또는 Ar2-C1-6알킬이고, R2,R5,R8및 R12는 각각 수소, C1-6알킬 또는 Ar2이고, R3,R6및 R11은 각각 수소 또는 C1-6알킬이고, R7및 R8은 각각 수소, C1-6알킬, C1-6알킬옥시 할로, 아미노, 또는 모노-또는 디(C1-6알킬)아미노이거나 Z는R 1 , R 4 and R 10 are each hydrogen, C 1-6 alkyl or Ar 2 -C 1-6 alkyl, and R 2 , R 5 , R 8 and R 12 are each hydrogen, C 1-6 alkyl or Ar 2 , R 3 , R 6 and R 11 are each hydrogen or C 1-6 alkyl, and R 7 and R 8 are each hydrogen, C 1-6 alkyl, C 1-6 alkyloxy halo, amino, or mono- Or di (C 1-6 alkyl) amino or Z is R13,R17및 R22는 각각 수소, 할로 C1-6알킬 트라플루오로메틸, C1-6알킬옥시, Ar2,Ar2-C1-6알킬, 아미노, 또는 모노-또는 디(C1-6알킬)아미노이고, R14,R16및 R21은 각각 수소, C1-6알킬 Ar2또는 Ar2-C1-6알킬이고, R15,R18및 R20은 각각 수소, C1-6알킬 또는 Ar2-C1-6알킬이고, R19는 수소 또는 C1-6알킬이고, R23은 수소, C1-6알킬이고, C1-6알킬 Ar2-C1-6알킬, 아미노 또는 모노(C1-6알킬)아미노이고, X3은 O 또는 S이거나 Z는R 13 , R 17 and R 22 are each hydrogen, halo C 1-6 alkyl trifluoromethyl, C 1-6 alkyloxy, Ar 2 , Ar 2 -C 1-6 alkyl, amino, or mono- or di ( C 1-6 alkyl) amino, R 14 , R 16 and R 21 are each hydrogen, C 1-6 alkyl Ar 2 or Ar 2 -C 1-6 alkyl, and R 15 , R 18 and R 20 are each hydrogen , C 1-6 alkyl or Ar 2 -C 1-6 alkyl, R 19 is hydrogen or C 1-6 alkyl, R 23 is hydrogen, C 1-6 alkyl, C 1-6 alkyl Ar 2 -C 1-6 alkyl, amino or mono (C 1-6 alkyl) amino, X 3 is O or S or Z is R24는 수소, 할로 C1-6알킬, C1-6알킬옥시, 아미노, 모노- 또는 디(C1-6알킬)아미노, Ar2또는 이미다졸릴이고, R25는 수소, C1-6알킬 또는 Ar1이고, R26및 R30은 각각 수소, C1-6알킬 Ar2-C1-C1-6알킬, 아미노 또는 모노(C1-6알킬)아미노이고, R27및 R31은 각각 수소, C1-6알킬 Ar1, C1-6알킬, C1-6알킬 카르보닐, Ar2-카르보닐, C1-6알킬옥시카르보닐, 카르복실, C1-6알킬옥시카르보닐 C1-4알킬, 아미노 카르보닐 또는 시아노이고, R28,R29,R32,R33및 R34는 각각 수소, C1-6알킬 또는 Ar2-C1-6알킬이고, n은 0 또는 1이고, Ar1은 페닐, 치환된 페닐, 나프탈레닐, 피리디닐, 이미다졸린, 트라아졸릴, 테에닐 푸라닐 또는 티리졸릴이고, Ar2는 페닐 또는 치환된 페닐인데, 상기 치환된 페닐은, 할로, 히드록시, 트리플루오로메틸, C1-6알킬, C1-6알킬옥시, 시아노, 아미노, 모노-또는 디(C1-6알킬)아미노, 니트로, 카르복시, 포로밀 및 C1-6알킬 옥시카르보닐로부터 선택한 3이하의 기로 치환된 페닐이다.R 24 is hydrogen, halo C 1-6 alkyl, C 1 - 6 alkyloxy, amino, mono- or di (C 1-6 alkyl) amino, Ar 2 or an imidazolyl, R 25 is hydrogen, C 1- 6 alkyl or Ar 1 , R 26 and R 30 are hydrogen, C 1-6 alkyl Ar 2 -C 1 -C 1-6 alkyl, amino or mono (C 1-6 alkyl) amino, and R 27 and R 31 Is hydrogen, C 1-6 alkyl Ar 1 , C 1-6 alkyl, C 1-6 alkyl carbonyl, Ar 2 -carbonyl, C 1-6 alkyloxycarbonyl, carboxyl, C 1-6 alkyloxy Carbonyl C 1-4 alkyl, amino carbonyl or cyano, R 28 , R 29 , R 32 , R 33 and R 34 are each hydrogen, C 1-6 alkyl or Ar 2 -C 1-6 alkyl, n is 0 or 1, Ar 1 is phenyl, substituted phenyl, naphthalenyl, pyridinyl, imidazoline, traazolyl, tenenyl furanyl or thirizolyl, and Ar 2 is phenyl or substituted phenyl , the substituted phenyl is optionally substituted by halo, hydroxy, trifluoromethyl, C 1-6 alkyl, C 1-6 alkyloxy, Cyano, amino, mono-or di (C 1-6 alkyl) amino, nitro, carboxy, C 1-6 captive mill and a substituted phenyl group of 3 or less selected from alkyloxycarbonyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890017783A 1988-11-29 1989-11-29 (1h-azol-1-yemethyl)substituted quinoline, quinazoline or quinoxaline derivatives KR0149162B1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
BE8827822 1988-11-29
GB88.27.822.1 1988-11-29
GB88.27.820.5 1988-11-29
BE8827820 1988-11-29
GB88.27.821.3 1988-11-29
BE8827821.3 1988-11-29
BE8827822.1 1988-11-29
BE8827820.5 1988-11-29
BE8827821 1988-11-29

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KR900007832A true KR900007832A (en) 1990-06-02
KR0149162B1 KR0149162B1 (en) 1998-10-15

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EA009875B1 (en) * 2003-11-20 2008-04-28 Янссен Фармацевтика Н.В. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416532A (en) * 2003-12-05 2007-01-09 Janssen Pharmaceutica Nv 6-substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors
WO2005058843A1 (en) * 2003-12-10 2005-06-30 Janssen Pharmaceutica N.V. Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
KR102231872B1 (en) * 2019-10-04 2021-03-26 성균관대학교산학협력단 Method for site-selective alkylation of Diazine-N-oxide using phosphonium ylides

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