KR900006299A - Method for preparing acyclic pyrimidine derivative - Google Patents

Method for preparing acyclic pyrimidine derivative Download PDF

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Publication number
KR900006299A
KR900006299A KR1019880013576A KR880013576A KR900006299A KR 900006299 A KR900006299 A KR 900006299A KR 1019880013576 A KR1019880013576 A KR 1019880013576A KR 880013576 A KR880013576 A KR 880013576A KR 900006299 A KR900006299 A KR 900006299A
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KR
South Korea
Prior art keywords
oxygen
hydrogen
formula
fluorine
methyl
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KR1019880013576A
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Korean (ko)
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KR900008169B1 (en
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김용해
김중영
이춘호
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전학제
한국과학기술원
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Priority to KR1019880013576A priority Critical patent/KR900008169B1/en
Priority to JP63304289A priority patent/JPH02138177A/en
Publication of KR900006299A publication Critical patent/KR900006299A/en
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Publication of KR900008169B1 publication Critical patent/KR900008169B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

비고리 피리미딘 유도체의 제조방법Method for preparing acyclic pyrimidine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

일반식(II)의 피리미딘 유도체에 요오드화 세슘과 아세토니트릴 용매 존재하에 2-아세톡시에틸 아세톡시메틸에테르 또는 0-클로로메틸-1,3-디-0-벤질글리세롤을 반응시키는 것을 특징으로 하는 일반식(I)의 비고리 피리미딘 유도체의 제조방법.Characterized in that a pyrimidine derivative of formula (II) is reacted with 2-acetoxyethyl acetoxymethyl ether or 0-chloromethyl-1,3-di-0-benzylglycerol in the presence of cesium iodide and acetonitrile solvent. Process for the preparation of acyclic pyrimidine derivatives of general formula (I). 일반식(I)에 있어서 Z는 2-아세톡시에톡시메틸기 또는 1,3-디-0-벤질프로폭시메틸기를 표시하고 X는 황 또는 산소를 표시한다. R1과 R2및 R3는 수소, 메틸, 아민, 산소, 불소를 표시한다.In General Formula (I), Z represents a 2-acetoxyethoxymethyl group or a 1,3-di-0-benzylpropoxymethyl group, and X represents sulfur or oxygen. R 1 and R 2 and R 3 represent hydrogen, methyl, amine, oxygen, fluorine. 일반식(II)에 있어서 X는 황 또는 산소를 표시하고 R1과 R2및 R3는 수소, 메틸, 아민, 산소, 불소를 표시한다.In general formula (II), X represents sulfur or oxygen, and R <1> , R <2> and R <3> represent hydrogen, methyl, an amine, oxygen, and fluorine. 제1항에 있어서, Z가 2-아세톡시에톡시메틸기의 경우 X가 황일 때에는 R1, R2및 R3모두가 수소이거나 R1이 산소이고 R2와 R3가 수소이거나 R1이 산소이고 R2가 메틸이며 R3가 수소이거나 X가 산소의 경우에는 R1이 산소이고 R2가 수소이며 R3가 수소이거나 R1이 산소이고 R2가 불소이며 R3수소이거나 R1이 산소이며 R2가 아민이고 R3가 수소로 이루어진 것이 특징인 일반식(I)의 비고리 피리미딘 유도체의 제조방법.The compound of claim 1, wherein in the case of Z is 2-acetoxyethoxymethyl group, when X is sulfur, R 1 , R 2 and R 3 are all hydrogen or R 1 is oxygen and R 2 and R 3 are hydrogen or R 1 is oxygen And R 2 is methyl and R 3 is hydrogen or X is oxygen, R 1 is oxygen, R 2 is hydrogen, R 3 is hydrogen, R 1 is oxygen, R 2 is fluorine, R 3 hydrogen or R 1 is oxygen And R 2 is an amine and R 3 is composed of hydrogen. A process for the preparation of acyclic pyrimidine derivatives of general formula (I). 제1항에 있어서, Z가 1,3-디-0-벤질프로폭시메틸기의 경우 X가 황이면 R1이 산소이고 R2및 R3가 수소이거나 R1이 산소이고 R2가 메틸이며 R3가 수소이거나 X가 산소이면 R1이 산소이고 R2와 R3가 수소이거나 R1이 산소이고 R2가 불소이며 R3가 수소로 이루어진 것이 특징인 일반식(I)의 비고리 피리미딘 유도체의 제조방법.2. The compound of claim 1 wherein Z is a 1,3-di-0-benzylpropoxymethyl group if X is sulfur, R 1 is oxygen and R 2 and R 3 are hydrogen or R 1 is oxygen and R 2 is methyl Acyclic pyrimidine of formula (I) characterized in that when trivalent hydrogen or X is oxygen R 1 is oxygen, R 2 and R 3 are hydrogen, R 1 is oxygen, R 2 is fluorine and R 3 is hydrogen Process for the preparation of derivatives. 제1항에 있어서, 요오드화 세슘의 첨가량이 일반식(II)의 피리미딘 유도체에 대해 몰비로 1 : 1을 가지는 것을 특징으로 하는 일반식(I)의 비고리 피리미딘 유도체의 제조방법.The method for producing acyclic pyrimidine derivatives of formula (I) according to claim 1, wherein the amount of cesium iodide added is 1: 1 in molar ratio relative to the pyrimidine derivative of formula (II). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880013576A 1988-10-18 1988-10-18 Process for prparing acyclic pyrimidine derivatives KR900008169B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019880013576A KR900008169B1 (en) 1988-10-18 1988-10-18 Process for prparing acyclic pyrimidine derivatives
JP63304289A JPH02138177A (en) 1988-10-18 1988-12-02 Preparation of non-cyclic pyrimidinenucleoside

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019880013576A KR900008169B1 (en) 1988-10-18 1988-10-18 Process for prparing acyclic pyrimidine derivatives

Publications (2)

Publication Number Publication Date
KR900006299A true KR900006299A (en) 1990-05-07
KR900008169B1 KR900008169B1 (en) 1990-11-05

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ID=19278570

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Application Number Title Priority Date Filing Date
KR1019880013576A KR900008169B1 (en) 1988-10-18 1988-10-18 Process for prparing acyclic pyrimidine derivatives

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JP (1) JPH02138177A (en)
KR (1) KR900008169B1 (en)

Also Published As

Publication number Publication date
JPH02138177A (en) 1990-05-28
KR900008169B1 (en) 1990-11-05

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